PDB: 83152 件ウェブページステータス検索Chemie searchBIRD

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8IL7	Structure of human soluble Adenylyl Cyclase in complex with lactate 分子名称: (2S)-2-HYDROXYPROPANOIC ACID, Adenylate cyclase type 10, GLYCEROL 著者 Li, Q.J, Li, Z.L, Gao, P. 登録日 2023-03-02 公開日 2023-07-26 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metab., 35, 2023
8IKZ	The mutant structure of DHAD 分子名称: Dihydroxy-acid dehydratase, chloroplastic, FE2/S2 (INORGANIC) CLUSTER, ... 著者 Zhou, J, Zang, X, Tang, Y, Yan, Y. 登録日 2023-03-01 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The mutant structure of DHAD To Be Published
8IKT	Ternary trans-complex of phospho-parkin with cis ACT and pUb 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-AMINOPROPANE, E3 ubiquitin-protein ligase parkin, ... 著者 Lenka, D.R, Kumar, A. 登録日 2023-03-01 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans Elife, 2024
8IKM	Trans complex of phospho parkin 分子名称: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... 著者 Lenka, D.R, Kumar, A. 登録日 2023-02-28 公開日 2024-09-11 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans Elife, 2024
8IKD	Structure of DNA binding domain of McrBC endonuclease bound to DNA: Y41F-L68Y double mutant 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(*GP*AP*GP*AP*CP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*CP*CP*GP*GP*TP*CP*TP*C)-3'), ... 著者 Adhav, V.A, Saikrishnan, K. 登録日 2023-02-28 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of target recognition by the DNA binding domain of McrBC To Be Published
8IK8	Structure of DNA binding domain of McrBC endonuclease bound to DNA: L68F mutant 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(*GP*AP*GP*AP*CP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*CP*CP*GP*GP*TP*CP*TP*C)-3'), ... 著者 Adhav, V.A, Saikrishnan, K. 登録日 2023-02-28 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis of target recognition by the DNA binding domain of McrBC To Be Published
8IK5	Transcription factor LMX1a homeobox domain in complex with Wnt1 promoter 分子名称: DNA (5'-D(*CP*CP*AP*TP*AP*TP*TP*TP*AP*AP*TP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*AP*TP*TP*AP*AP*AP*TP*AP*TP*G)-3'), GLYCEROL, ... 著者 Lv, M.Q, Lin, L.Q. 登録日 2023-02-28 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.989 Å) 主引用文献 Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
8IK4	Structure of DNA binding domain of McrBC endonuclease bound to hemimethylated DNA: L68F mutant 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(*AP*GP*AP*(5CM)P*CP*GP*GP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*CP*CP*GP*GP*TP*CP*T)-3'), ... 著者 Adhav, V.A, Saikrishnan, K. 登録日 2023-02-28 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of target recognition by the DNA binding domain of McrBC To Be Published
8IK3	Structure of Stimulator of interferon genes/ligand complex 分子名称: Stimulator of interferon genes protein,Immune protein Tsi3, cGAMP 著者 Lu, D.F, Shang, G.J. 登録日 2023-02-28 公開日 2023-05-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The mechanism of STING autoinhibition and activation. Mol.Cell, 83, 2023
8IK0	Cryo-EM structure of Stimulator of interferon genes 分子名称: Stimulator of interferon genes protein,Immune protein Tsi3 著者 Lu, D.F, Shang, G.J. 登録日 2023-02-28 公開日 2023-05-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The mechanism of STING autoinhibition and activation. Mol.Cell, 83, 2023
8IJY	Synechococcus elongatus 6-4 photolyase with an 8-HDF as the antenna chromophore and a covalently linked FAD as the catalytic cofactor 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 8-HYDROXY-10-(D-RIBO-2,3,4,5-TETRAHYDROXYPENTYL)-5-DEAZAISOALLOXAZINE, Deoxyribodipyrimidine photolyase-related protein, ... 著者 Liu, Y, Xu, L, Zhang, P. 登録日 2023-02-28 公開日 2024-09-04 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Synechococcus elongatus 6-4 photolyase with an 8-HDF as the antenna chromophore and a covalently linked FAD as the catalytic cofactor To Be Published
8IJX	Cryo-EM structure of the gastric proton pump with bound DQ-18 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[4-[(5-chloranyl-2-phenylmethoxy-phenyl)methoxy]phenyl]-N-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Abe, K, Yokoshima, S, Yoshimori, A. 登録日 2023-02-28 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (2.08 Å) 主引用文献 Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8IJW	Cryo-EM structure of the gastric proton pump with bound DQ-06 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... 著者 Abe, K, Yokoshima, S, Yoshimori, A. 登録日 2023-02-28 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (2.19 Å) 主引用文献 Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8IJV	Cryo-EM structure of the gastric proton pump with bound DQ-02 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[[5-chloranyl-2-(4-chlorophenyl)phenyl]methoxy]-N-methyl-but-2-yn-1-amine, ... 著者 Abe, K, Yokoshima, S, Yoshimori, A. 登録日 2023-02-28 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 Deep learning driven de novo drug design based on gastric proton pump structures. Commun Biol, 6, 2023
8IJU	ATP-dependent RNA helicase DDX39A (URH49delta41) 分子名称: 1,2-ETHANEDIOL, ATP-dependent RNA helicase DDX39A, PHOSPHATE ION, ... 著者 Mikami, B, Fujita, K, Masuda, S, Kojima, M. 登録日 2023-02-28 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes. Nat Commun, 15, 2024
8IJR	The cryo-EM structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine 分子名称: (2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11Z)-octadec-11-enoate, PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1 著者 Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. 登録日 2023-02-28 公開日 2024-02-28 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.29 Å) 主引用文献 Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat.Struct.Mol.Biol., 31, 2024
8IJQ	The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide 分子名称: N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, Sphingomyelin synthase-related protein 1 著者 Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. 登録日 2023-02-27 公開日 2024-02-28 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis. Nat.Struct.Mol.Biol., 31, 2024
8IJP	Structure of DNA binding domain of McrBC endonuclease bound to DNA: L68Y mutant 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(*GP*AP*GP*AP*CP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*CP*CP*GP*GP*TP*CP*TP*C)-3'), ... 著者 Adhav, V.A, Saikrishnan, K. 登録日 2023-02-27 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis of target recognition by the DNA binding domain of McrBC To Be Published
8IJO	Structure of DNA binding domain of McrBC endonuclease bound to DNA: Y41F-L68F double mutant 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(*GP*AP*GP*AP*CP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*CP*CP*GP*GP*TP*CP*TP*C)-3'), ... 著者 Adhav, V.A, Saikrishnan, K. 登録日 2023-02-27 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis of target recognition by the DNA binding domain of McrBC To Be Published
8IJN	Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K 分子名称: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... 著者 Tsukihara, T, Shimada, A, Muramoto, K. 登録日 2023-02-27 公開日 2023-04-12 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Bovine cytochrome c oxidase structures enable O2 reduction with minimization of reactive oxygens and provide a proton-pumping gate. Proc.Natl.Acad.Sci.USA, 107, 2010
8IJM	Cyo-EM structure of K794A non-gastric proton pump in Na+ bound E1AMPPCP state 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... 著者 Abe, K. 登録日 2023-02-27 公開日 2023-08-02 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 An unusual conformation from Na + -sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na + -binding. Biochim Biophys Acta Mol Cell Res, 1870, 2023
8IJL	Cyo-EM structure of wildtype non-gastric proton pump in the presence of Na+, AlF and ADP 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ... 著者 Abe, K. 登録日 2023-02-27 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (2.62 Å) 主引用文献 An unusual conformation from Na + -sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na + -binding. Biochim Biophys Acta Mol Cell Res, 1870, 2023
8IJD	Cryo-EM structure of human HCAR2-Gi complex with MK-6892 分子名称: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Pan, X, Fang, Y. 登録日 2023-02-27 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
8IJC	NMR solution structure of the 1:1 complex of a platinum(II) ligand L1-transpt covalently bound to a G-quadruplex MYT1L 分子名称: G-quadruplex DNA MYT1L, Pt(NH3)2(2-(pyridin-4-ylmethyl)benzo-[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone) 著者 Liu, L.-Y, Mao, Z.-W. 登録日 2023-02-27 公開日 2023-06-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy. Angew.Chem.Int.Ed.Engl., 62, 2023
8IJB	Cryo-EM structure of human HCAR2-Gi complex with acipimox 分子名称: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Pan, X, Fang, Y. 登録日 2023-02-27 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023

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