8IJC

NMR solution structure of the 1:1 complex of a platinum(II) ligand L1-transpt covalently bound to a G-quadruplex MYT1L

Summary for 8IJC

• Entry DOI: 10.2210/pdb8ijc/pdb
• Descriptor: G-quadruplex DNA MYT1L, Pt(NH3)2(2-(pyridin-4-ylmethyl)benzo-[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone) (2 entities in total)
• Functional Keywords: g-quadruplex dna, quadruplex-duplex hybrid, platinum complex, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 9803.36

Authors

Liu, L.-Y.,Mao, Z.-W. (deposition date: 2023-02-27, release date: 2023-06-28, Last modification date: 2024-05-15)

• Primary citation: Liu, L.Y.,Ma, T.Z.,Zeng, Y.L.,Liu, W.,Zhang, H.,Mao, Z.W.; Organic-Platinum Hybrids for Covalent Binding of G-Quadruplexes: Structural Basis and Application to Cancer Immunotherapy.; Angew.Chem.Int.Ed.Engl., 62:e202305645-e202305645, 2023; PubMed: 37464955; DOI: 10.1002/anie.202305645

Experimental method

SOLUTION NMR