PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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4GCZ	Structure of a blue-light photoreceptor 分子名称: ADENOSINE-5'-DIPHOSPHATE, Blue-light photoreceptor, Sensor protein fixL, ... 著者 Diensthuber, R.P, Bommer, M, Moglich, A. 登録日 2012-07-31 公開日 2013-06-19 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Full-length structure of a sensor histidine kinase pinpoints coaxial coiled coils as signal transducers and modulators. Structure, 21, 2013
4GFH	Topoisomerase II-DNA-AMPPNP complex 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), ... 著者 Schmidt, B.H, Osheroff, N, Berger, J.M. 登録日 2012-08-03 公開日 2012-10-03 最終更新日 2019-07-31 実験手法 X-RAY DIFFRACTION (4.408 Å) 主引用文献 Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat.Struct.Mol.Biol., 19, 2012
4JUO	A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32 分子名称: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, ... 著者 Laponogov, I, Veselkov, D.A, Pan, X.-S, Crevel, I, Fisher, L.M, Sanderson, M.R. 登録日 2013-03-25 公開日 2013-08-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (6.53 Å) 主引用文献 Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport. Nucleic Acids Res., 41, 2013
4JAS	Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E and RR468mutant V13P, L14I, I17M and N21V) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Histidine kinase, MAGNESIUM ION, ... 著者 Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. 登録日 2013-02-19 公開日 2013-09-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
4JAU	Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Histidine kinase 著者 Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. 登録日 2013-02-19 公開日 2013-09-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
4I5S	Structure and function of sensor histidine kinase 分子名称: Putative histidine kinase CovS; VicK-like protein 著者 Cai, Y. 登録日 2012-11-28 公開日 2013-03-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains Plos Biol., 11, 2013
4HY1	Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. 分子名称: 6-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1H-isoindol-1-one, Topoisomerase IV, subunit B 著者 Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. 登録日 2012-11-12 公開日 2013-02-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
4I3H	A three-gate structure of topoisomerase IV from Streptococcus pneumoniae 分子名称: DNA (5'-D(*CP*AP*AP*AP*GP*GP*CP*GP*GP*TP*AP*AP*TP*AP*CP*GP*GP*TP*TP*AP*TP*CP*CP*AP*CP*AP*GP*AP*AP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*TP*TP*CP*TP*GP*TP*GP*GP*AP*TP*AP*AP*CP*CP*GP*TP*AP*TP*TP*AP*CP*CP*GP*CP*CP*TP*TP*TP*G)-3'), MAGNESIUM ION, ... 著者 Laponogov, I, Veselkov, D.A, Pan, X.-S, Crevel, I, Fisher, L.M, Sanderson, M.R. 登録日 2012-11-26 公開日 2013-08-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport. Nucleic Acids Res., 41, 2013
4HXZ	Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. 分子名称: 6-ethyl-4-methoxy-2-(pyridin-3-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde, Topoisomerase IV, subunit B 著者 Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. 登録日 2012-11-12 公開日 2013-02-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
4HYM	Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. 分子名称: 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)pyrido[2,3-b]pyrazin-2(1H)-one, Topoisomerase IV, subunit B 著者 Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. 登録日 2012-11-13 公開日 2013-02-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
4JPB	The structure of a ternary complex between CheA domains P4 and P5 with CheW and with an unzipped fragment of TM14, a chemoreceptor analog from Thermotoga maritima. 分子名称: Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein 著者 Li, X, Bayas, C, Bilwes, A.M, Crane, B.R. 登録日 2013-03-19 公開日 2013-08-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.186 Å) 主引用文献 The 3.2 angstrom resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays. Biochemistry, 52, 2013
4JAV	Structural basis of a rationally rewired protein-protein interface (HK853wt and RR468mutant V13P, L14I, I17M and N21V) 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Histidine kinase, ... 著者 Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. 登録日 2013-02-19 公開日 2013-09-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21, 2013
4KQV	Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor 分子名称: 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, IODIDE ION, Topoisomerase IV, ... 著者 Bensen, D.C, Akers-Rodriguez, S, Lam, T, Tari, L.W. 登録日 2013-05-15 公開日 2014-01-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity To be Published
3A0R	Crystal structure of histidine kinase ThkA (TM1359) in complex with response regulator protein TrrA (TM1360) 分子名称: MERCURY (II) ION, Response regulator, Sensor protein 著者 Yamada, S, Sugimoto, H, Kobayashi, M, Ohno, A, Nakamura, H, Shiro, Y. 登録日 2009-03-24 公開日 2009-10-20 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structure of PAS-linked histidine kinase and the response regulator complex Structure, 17, 2009
6RFV	Revisiting pH-gated conformational switch. Complex HK853-RR468 pH 7 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Response regulator, ... 著者 Mideros-Mora, C, Casino, P, Marina, A. 登録日 2019-04-16 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020
6RKW	CryoEM structure of the complete E. coli DNA Gyrase complex bound to a 130 bp DNA duplex 分子名称: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (58-MER), DNA (62-MER), ... 著者 Vanden Broeck, A, Lamour, V. 登録日 2019-04-30 公開日 2019-11-06 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (6.6 Å) 主引用文献 Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex. Nat Commun, 10, 2019
6RKS	E. coli DNA Gyrase - DNA binding and cleavage domain in State 1 without TOPRIM insertion 分子名称: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA Strand 1, DNA Strand 2, ... 著者 Vanden Broeck, A, Lamour, V. 登録日 2019-04-30 公開日 2019-11-06 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex. Nat Commun, 10, 2019
6S1K	E. coli Core Signaling Unit, carrying QQQQ receptor mutation 分子名称: CheW, Chemotaxis protein CheA, Methyl-accepting chemotaxis protein I 著者 Cassidy, C.K. 登録日 2019-06-18 公開日 2020-01-22 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (8.38 Å) 主引用文献 Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations. Commun Biol, 3, 2020
6RH2	Revisiting pH-gated conformational switch. Complex HK853-RR468 D53A pH 5.3 分子名称: ADENOSINE-5'-DIPHOSPHATE, Response regulator, SULFATE ION, ... 著者 Mideros-Mora, C, Casino, P, Marina, A. 登録日 2019-04-18 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020
6RH7	Revisiting pH-gated conformational switch. Complex HK853 mutant H260A -RR468 mutant D53A pH 7.5 分子名称: ADENOSINE-5'-DIPHOSPHATE, Response regulator, SULFATE ION, ... 著者 Mideros-Mora, C, Casino, P, Marina, A. 登録日 2019-04-18 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020
6RH1	Revisiting pH-gated conformational switch. Complex HK853-RR468 D53A pH 7 分子名称: ADENOSINE-5'-DIPHOSPHATE, Response regulator, SULFATE ION, ... 著者 Mideros-Mora, C, Casino, P, Marina, A. 登録日 2019-04-18 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020
6RH0	Revisiting pH-gated conformational switch. Complex HK853-RR468 pH 5.5 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Response regulator, ... 著者 Mideros-Mora, C, Casino, P, Marina, A. 登録日 2019-04-18 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020
6RKV	E. coli DNA Gyrase - DNA binding and cleavage domain in State 2 分子名称: DNA Strand 1, DNA Strand 2, DNA gyrase subunit A, ... 著者 Vanden Broeck, A, Lamour, V. 登録日 2019-04-30 公開日 2019-11-06 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex. Nat Commun, 10, 2019
6RKU	E. coli DNA Gyrase - DNA binding and cleavage domain in State 1 分子名称: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA Strand 1, DNA Strand 2, ... 著者 Vanden Broeck, A, Lamour, V. 登録日 2019-04-30 公開日 2019-11-06 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex. Nat Commun, 10, 2019
6RGY	Revisiting pH-gated conformational switch. Complex HK853-RR468 pH 7.5 分子名称: ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, MAGNESIUM ION, ... 著者 Mideros-Mora, C, Casino, P, Marina, A. 登録日 2019-04-18 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nat Commun, 11, 2020

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