PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5OLA	Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM 分子名称: DNA (30-MER), DNA (5'-D(P*AP*TP*GP*GP*TP*GP*TP*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*GP*AP*AP*C)-3'), DNA-directed RNA polymerase, ... 著者 Hillen, H.S, Parshin, A.V, Agaronyan, K, Morozov, Y, Graber, J.J, Chernev, A, Schwinghammer, K, Urlaub, H, Anikin, M, Cramer, P, Temiakov, D. 登録日 2017-07-27 公開日 2017-10-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.904 Å) 主引用文献 Mechanism of Transcription Anti-termination in Human Mitochondria. Cell, 171, 2017
6ELI	Structure of HIV-1 reverse transcriptase (RT) in complex with rilpivirine and an RNase H inhibitor XZ462 分子名称: 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, Gag-Pol polyprotein, ... 著者 Das, K, Arnold, E. 登録日 2017-09-29 公開日 2018-04-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase. J. Virol., 92, 2018
8D9D	Human DNA polymerase-alpha/primase elongation complex II bound to primer/template 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... 著者 He, Q, Baranovskiy, A, Lim, C, Tahirov, T. 登録日 2022-06-09 公開日 2023-04-19 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
8PMP	Structure of the human nuclear cap-binding complex bound to ARS2[147-871] and m7GTP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... 著者 Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. 登録日 2023-06-29 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.43 Å) 主引用文献 Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43, 2024
8FOK	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state 分子名称: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... 著者 Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. 登録日 2022-12-30 公開日 2023-05-31 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.56 Å) 主引用文献 Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8G5N	Cryo-EM structure of the Guide loop Engagement Complex (VI) of Human Mitochondrial DNA Polymerase Gamma 分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... 著者 Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. 登録日 2023-02-13 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Structural basis for DNA proofreading. Nat Commun, 14, 2023
8G5M	Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma 分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... 著者 Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. 登録日 2023-02-13 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Structural basis for DNA proofreading. Nat Commun, 14, 2023
8G5O	Cryo-EM structure of the Guide loop Engagement Complex (IV) of Human Mitochondrial DNA Polymerase Gamma 分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... 著者 Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. 登録日 2023-02-13 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Structural basis for DNA proofreading. Nat Commun, 14, 2023
6S1O	Human polymerase delta holoenzyme Conformer 3 分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... 著者 Lancey, C, Hamdan, S.M, De Biasio, A. 登録日 2019-06-19 公開日 2019-12-25 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (8.1 Å) 主引用文献 Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
5FML	Crystal structure of the endonuclease from the PA subunit of influenza B virus bound to the PB2 subunit NLS peptide 分子名称: GLYCEROL, MAGNESIUM ION, PA SUBUNIT OF INFLUENZA B POLYMERASE, ... 著者 Guilligay, D, Gaudon, S, Cusack, S. 登録日 2015-11-06 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
6S1N	Human polymerase delta holoenzyme Conformer 2 分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... 著者 Lancey, C, Hamdan, S.M, De Biasio, A. 登録日 2019-06-19 公開日 2019-12-25 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.86 Å) 主引用文献 Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
5NFY	SARS-CoV nsp10/nsp14 dynamic complex 分子名称: DI(HYDROXYETHYL)ETHER, Polyprotein 1ab, ZINC ION 著者 Ferron, F, Gluais, L, Vonrhein, C, Bricogne, G, Canard, B, Imbert, I. 登録日 2017-03-16 公開日 2018-01-10 最終更新日 2019-02-20 実験手法 X-RAY DIFFRACTION (3.382 Å) 主引用文献 Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6S1M	Human polymerase delta holoenzyme Conformer 1 分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ... 著者 Lancey, C, Hamdan, S.M, De Biasio, A. 登録日 2019-06-19 公開日 2019-12-25 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.27 Å) 主引用文献 Structure of the processive human Pol delta holoenzyme. Nat Commun, 11, 2020
7Y38	Molecular architecture of the chikungunya virus replication complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Protease nsP2, ... 著者 Tan, Y.B, Luo, D. 登録日 2022-06-10 公開日 2022-12-14 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Molecular architecture of the Chikungunya virus replication complex. Sci Adv, 8, 2022
3NMA	Mutant P169S of Foot-and-mouth disease Virus RNA dependent RNA-polymerase 分子名称: 5'-R(*GP*GP*C)-3', 5'-R(P*CP*C)-3', Genome polyprotein, ... 著者 Agudo, R, Ferrer-Orta, C, Arias, A, Perez-Luque, R, Verdaguer, N, Domingo, E. 登録日 2010-06-22 公開日 2011-05-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. Plos Pathog., 6, 2010
5FMM	crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza a virus polymerase PB2 subunit bound to M7GTP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CITRATE ANION, INFLUENZA A PB2 SUBUNIT 著者 Thierry, E, Pflug, A, Hart, D, Cusack, S. 登録日 2015-11-06 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
6Y6K	Cryo-EM structure of a Phenuiviridae L protein 分子名称: MAGNESIUM ION, RNA-dependent RNA polymerase 著者 Vogel, D, Thorkelsson, S.R, Quemin, E, Meier, K, Kouba, T, Gogrefe, N, Busch, C, Reindl, S, Guenther, S, Cusack, S, Gruenewald, K, Rosenthal, M. 登録日 2020-02-26 公開日 2020-04-08 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 48, 2020
5FMQ	Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, INFLUENZA A PB2 SUBUNIT 著者 Thierry, E, Pflug, A, Hart, D, Cusack, S. 登録日 2015-11-07 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
4YPI	Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived from Ebola VP35 分子名称: Nucleoprotein, Polymerase cofactor VP35 著者 Leung, D.W, Borek, D.M, Binning, J.M, Otwinowski, Z, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2015-03-13 公開日 2015-04-08 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (3.71 Å) 主引用文献 An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. Cell Rep, 11, 2015
8D0K	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC 分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... 著者 He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. 登録日 2022-05-26 公開日 2022-06-22 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (4.27 Å) 主引用文献 Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
4QCL	Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA TEMPLATE, ... 著者 Baranovskiy, A.G, Suwa, Y, Babayeva, N.D, Gu, J, Tahirov, T.H. 登録日 2014-05-12 公開日 2014-11-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Activity and fidelity of human DNA polymerase alpha depend on primer structure J.Biol.Chem., 2018
8FOE	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA 分子名称: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... 著者 Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. 登録日 2022-12-30 公開日 2023-05-31 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8FOD	Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II 分子名称: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... 著者 Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. 登録日 2022-12-30 公開日 2023-05-31 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
8D0B	Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template 分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... 著者 He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. 登録日 2022-05-26 公開日 2022-06-22 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.43 Å) 主引用文献 Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
8G5P	Cryo-EM structure of the Guide loop Engagement Complex (V) of Human Mitochondrial DNA Polymerase Gamma 分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... 著者 Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. 登録日 2023-02-13 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (2.78 Å) 主引用文献 Structural basis for DNA proofreading. Nat Commun, 14, 2023

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