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8FS6
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BU of 8fs6 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 4 (partially closed 9-1-1 and stably bound chamber DNA)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
著者Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
登録日2023-01-09
公開日2023-06-14
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
8FCN
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BU of 8fcn by Molmil
Cryo-EM structure of p97:UBXD1 VIM-only state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
著者Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
登録日2022-12-01
公開日2023-06-21
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCT
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BU of 8fct by Molmil
Cryo-EM structure of p97:UBXD1 lariat mutant
分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
著者Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
登録日2022-12-01
公開日2023-06-21
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCL
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BU of 8fcl by Molmil
Cryo-EM structure of p97:UBXD1 closed state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
著者Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
登録日2022-12-01
公開日2023-06-21
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.51 Å)
主引用文献The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCP
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BU of 8fcp by Molmil
Cryo-EM structure of p97:UBXD1 para state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
著者Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
登録日2022-12-01
公開日2023-06-21
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCR
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BU of 8fcr by Molmil
Cryo-EM structure of p97:UBXD1 H4-bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
著者Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
登録日2022-12-01
公開日2023-06-21
最終更新日2023-12-20
実験手法ELECTRON MICROSCOPY (4.12 Å)
主引用文献The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8HL7
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BU of 8hl7 by Molmil
Crystal structure of p97 N/D1 in complex with a valosin-containing protein methyltransferase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
著者Kang, W, Yang, J.K.
登録日2022-11-29
公開日2023-07-12
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase.
Iscience, 26, 2023
7KSM
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BU of 7ksm by Molmil
Human mitochondrial LONP1 with endogenous substrate
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ...
著者Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
登録日2020-11-23
公開日2020-12-02
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7KRZ
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BU of 7krz by Molmil
Human mitochondrial LONP1 in complex with Bortezomib
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ...
著者Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
登録日2020-11-20
公開日2021-02-24
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7JK2
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BU of 7jk2 by Molmil
Structure of Drosophila ORC bound to poly(dA/dT) DNA and Cdc6 (conformation 1)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ...
著者Schmidt, J.M, Bleichert, F.
登録日2020-07-27
公開日2020-09-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020
7JK3
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BU of 7jk3 by Molmil
Structure of Drosophila ORC bound to GC-rich DNA and Cdc6
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ...
著者Schmidt, J.M, Bleichert, F.
登録日2020-07-27
公開日2020-09-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020
7JPR
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BU of 7jpr by Molmil
ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ...
著者Jaremko, M.J, Joshua-Tor, L.
登録日2020-08-09
公開日2020-09-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
Elife, 9, 2020
8H3H
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BU of 8h3h by Molmil
Human ATAD2 Walker B mutant, ATP state
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2
著者Cho, C, Song, J.
登録日2022-10-08
公開日2023-10-18
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Commun Biol, 6, 2023
7JPP
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BU of 7jpp by Molmil
ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ...
著者Jaremko, M.J, Joshua-Tor, L.
登録日2020-08-09
公開日2020-09-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
Elife, 9, 2020
7JK4
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BU of 7jk4 by Molmil
Structure of Drosophila ORC bound to AT-rich DNA and Cdc6
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (34-MER), ...
著者Schmidt, J.M, Bleichert, F.
登録日2020-07-27
公開日2020-09-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
Nat Commun, 11, 2020
8D6Y
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BU of 8d6y by Molmil
Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ADP-bound Mpa ATPase
分子名称: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ...
著者Xiao, X, Li, H.
登録日2022-06-06
公開日2022-08-03
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (10 Å)
主引用文献The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation.
Msphere, 7, 2022
8CVT
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BU of 8cvt by Molmil
Human 19S-20S proteasome, state SD2
分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ...
著者Zhao, J.
登録日2022-05-18
公開日2022-11-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6X
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BU of 8d6x by Molmil
Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ATP-bound Mpa ATPase
分子名称: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta, ...
著者Xiao, X, Li, H.
登録日2022-06-06
公開日2022-08-03
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The beta-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation.
Msphere, 7, 2022
8DAW
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BU of 8daw by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uD)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
著者Lee, H.G, Lima, C.D.
登録日2022-06-14
公開日2022-11-30
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAU
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BU of 8dau by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two folded ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (uA)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
著者Lee, H.G, Lima, C.D.
登録日2022-06-14
公開日2022-11-30
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAR
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BU of 8dar by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex unbound but in the presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
著者Lee, H.G, Lima, C.D.
登録日2022-06-14
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAT
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BU of 8dat by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to three ubiquitin moieties in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (intB)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
著者Lee, H.G, Lima, C.D.
登録日2022-06-14
公開日2022-11-30
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAS
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BU of 8das by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two ubiquitin moieties in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 1 (intA)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
著者Lee, H.G, Lima, C.D.
登録日2022-06-14
公開日2022-11-30
最終更新日2023-01-11
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DAV
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BU of 8dav by Molmil
Saccharomyces cerevisiae Ufd1/Npl4/Cdc48 complex bound to two ubiquitin moieties and one unfolded ubiquitin in presence of SUMO-ubiquitin(K48polyUb)-mEOS and ATP, state 2 (uC)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ...
著者Lee, H.G, Lima, C.D.
登録日2022-06-14
公開日2022-11-30
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DR0
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BU of 8dr0 by Molmil
Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction
分子名称: DNA (5'-D(P*CP*CP*CP*CP*GP*GP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*CP*GP*GP*GP*GP*GP*GP*GP*CP*CP*CP*CP*GP*GP*GP*G)-3'), GUANOSINE-5'-DIPHOSPHATE, ...
著者Schrecker, M, Hite, R.K.
登録日2022-07-20
公開日2022-08-24
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.42 Å)
主引用文献Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
Elife, 11, 2022

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件を2024-11-13に公開中

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