PDB: 970 件ウェブページステータス検索Chemie searchBIRD

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5J5X	Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1416 分子名称: 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAL-DAR-DAR-DAR-DAR, SULFATE ION, ... 著者 Alam, K.A, Ivan, T, Uri, A, Engh, R.A. 登録日 2016-04-04 公開日 2016-07-20 最終更新日 2019-06-19 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27, 2016
4WIH	Crystal structure of cAMP-dependent Protein Kinase A from Cricetulus griseus 分子名称: cAMP Dependent Protein Kinase Inhibitor PKI-tide, cAMP-dependent protein kinase catalytic subunit alpha 著者 Kudlinzki, D, Linhard, V.L, Saxena, K, Dreyer, M, Schwalbe, H. 登録日 2014-09-25 公開日 2014-10-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.139 Å) 主引用文献 High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus. Acta Crystallogr.,Sect.F, 71, 2015
6Z44	Crystal structure of the cAMP-dependent protein kinase A in complex with phenol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, PHENOL, ... 著者 Oebbeke, M, Heine, A, Klebe, G. 登録日 2020-05-22 公開日 2020-12-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
5J3J	Crystal Structure of human DPP-IV in complex with HL1 分子名称: (2~{S},3~{R})-8,9-dimethoxy-3-[2,4,5-tris(fluoranyl)phenyl]-2,3-dihydro-1~{H}-benzo[f]chromen-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... 著者 Wu, F, Li, H, Zhao, Z, Zhu, L, Xu, H, Li, S. 登録日 2016-03-31 公開日 2017-04-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal Structure of human DPP-IV in complex with HL1 To Be Published
5KBY	Crystal structure of dipeptidyl peptidase IV in complex with SYR-472 分子名称: 2-[[6-[(3~{R})-3-azanylpiperidin-1-yl]-3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]methyl]-4-fluoranyl-benzenecarboni trile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Skene, R.J, Jennings, A.J. 登録日 2016-06-03 公開日 2016-07-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism. Plos One, 11, 2016
5EFU	Resting state of rat cysteine dioxygenase H155Q variant 分子名称: Cysteine dioxygenase type 1, FE (II) ION 著者 Fellner, M, Tchesnokov, E.P, Jameson, G.N.L, Wilbanks, S.M. 登録日 2015-10-26 公開日 2016-10-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Resting state of rat cysteine dioxygenase H155Q variant To be published
4X6R	An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Wu, J, Taylor, S.S. 登録日 2014-12-09 公開日 2015-07-22 最終更新日 2020-06-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure, 23, 2015
5ERA	Human Connexin-26 (Calcium-free) 分子名称: Gap junction beta-2 protein 著者 Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. 登録日 2015-11-13 公開日 2016-01-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun, 7, 2016
4X6Q	An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit 著者 Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Taylor, S.S. 登録日 2014-12-08 公開日 2015-07-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure, 23, 2015
5ER7	Connexin-26 Bound to Calcium 分子名称: CALCIUM ION, Gap junction beta-2 protein 著者 Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. 登録日 2015-11-13 公開日 2016-01-27 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (3.286 Å) 主引用文献 An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun, 7, 2016
6ZN0	Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with isonicotinamidine 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, ISONICOTINAMIDINE, ... 著者 Oebbeke, M, Heine, A, Klebe, G. 登録日 2020-07-06 公開日 2020-12-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60, 2021
4XEZ	cysteine dioxygenase variant - Y157F at pH 8.0 with dithionite 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (III) ION, ... 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-25 公開日 2016-03-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.2469 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XF3	cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine and dithionite 分子名称: CYSTEINE, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-25 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XFC	cysteine dioxygenase variant - Y157F at pH 6.2 unliganded 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.351 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XET	Fe-Cl bound Y157F CDO at pH ~7.0 in the presence of azide 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-24 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XF0	cysteine dioxygenase variant - C93A at pH 8.0 with cysteine 分子名称: CHLORIDE ION, CYSTEINE, Cysteine dioxygenase type 1, ... 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-25 公開日 2016-03-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3994 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XFG	cysteine dioxygenase variant - C93A at pH 6.2 with cysteine 分子名称: CHLORIDE ION, CYSTEINE, Cysteine dioxygenase type 1, ... 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.401 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XF1	cysteine dioxygenase variant - Y157F at pH 8.0 with cysteine 分子名称: CYSTEINE, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-25 公開日 2016-04-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XF9	cysteine dioxygenase variant - C93A at pH 8.0 in complex with homocysteine 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
5EZW	Thiosulfate bound rat cysteine dioxygenase Y157H variant 分子名称: Cysteine dioxygenase type 1, FE (II) ION, THIOSULFATE 著者 Fellner, M, Tchesnokov, E.P, Jameson, G.N.L, Wilbanks, S.M. 登録日 2015-11-27 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Thiosulfate bound rat cysteine dioxygenase Y157H variant To be published
5JR7	Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA 分子名称: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit 著者 Bruystens, J.G.H, Wu, J, Taylor, S.S. 登録日 2016-05-05 公開日 2017-03-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.56 Å) 主引用文献 Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428, 2016
4XW6	X-ray structure of PKAc with ADP, free phosphate ion, CP20, magnesium ions 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Gerlits, O, Tian, J, Das, A, Taylor, S, Langan, P, Heller, T.W, Kovalevsky, A. 登録日 2015-01-28 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J.Biol.Chem., 290, 2015
4XF4	Cysteine dioxygenase at pH 8.0 in complex with homocysteine 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-03-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.3485 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XW5	X-ray structure of PKAc with ATP, CP20, calcium ions 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Gerlits, O, Tian, J, Das, A, Taylor, S, Langan, P, Heller, T.W, Kovalevsky, A. 登録日 2015-01-28 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J.Biol.Chem., 290, 2015
4XFH	cysteine dioxygenase variant - Y157F at pH 6.2 with cysteine 分子名称: CYSTEINE, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016

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