5KBY
Crystal structure of dipeptidyl peptidase IV in complex with SYR-472
Summary for 5KBY
Entry DOI | 10.2210/pdb5kby/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | peptidase, glp-1, metabolic disease, co-complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 350397.83 |
Authors | Skene, R.J.,Jennings, A.J. (deposition date: 2016-06-03, release date: 2016-07-13, Last modification date: 2023-09-27) |
Primary citation | Grimshaw, C.E.,Jennings, A.,Kamran, R.,Ueno, H.,Nishigaki, N.,Kosaka, T.,Tani, A.,Sano, H.,Kinugawa, Y.,Koumura, E.,Shi, L.,Takeuchi, K. Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism. Plos One, 11:e0157509-e0157509, 2016 Cited by PubMed: 27328054DOI: 10.1371/journal.pone.0157509 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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