PDB: 499 件ウェブページステータス検索Chemie searchBIRD

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8JH2	RNA polymerase II elongation complex bound with Elf1, Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome 分子名称: DNA (218-MER), DNA (40-MER), DNA-directed RNA polymerase subunit, ... 著者 Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. 登録日 2023-05-22 公開日 2023-11-29 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (5.7 Å) 主引用文献 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
2W42	THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX. 分子名称: 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ... 著者 Parker, J.S, Roe, S.M, Barford, D. 登録日 2008-11-19 公開日 2008-12-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein Mol.Cell, 33, 2009
2YHA	Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains 分子名称: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION 著者 Boland, A, Weichenrieder, O. 登録日 2011-04-27 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein Proc.Natl.Acad.Sci.USA, 108, 2011
2YHB	Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains 分子名称: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION 著者 Boland, A, Weichenrieder, O. 登録日 2011-04-27 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein Proc.Natl.Acad.Sci.USA, 108, 2011
3H0G	RNA Polymerase II from Schizosaccharomyces pombe 分子名称: DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Spahr, H, Calero, G, Bushnell, D.A, Kornberg, R.D. 登録日 2009-04-09 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution. Proc.Natl.Acad.Sci.USA, 106, 2009
8H0V	RNA polymerase II transcribing a chromatosome (type I) 分子名称: DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. 登録日 2022-09-30 公開日 2022-12-07 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Nat Commun, 13, 2022
8H0W	RNA polymerase II transcribing a chromatosome (type II) 分子名称: DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. 登録日 2022-09-30 公開日 2022-12-07 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Nat Commun, 13, 2022
8HE5	RNA polymerase II elongation complex bound with Rad26 and Elf1, stalled at SHL(-3.5) of the nucleosome 分子名称: DNA (198-MER), DNA repair protein, DNA-directed RNA polymerase subunit, ... 著者 Osumi, K, Kujirai, T, Ehara, H, Kinoshita, C, Saotome, M, Kagawa, W, Sekine, S, Takizawa, Y, Kurumizaka, H. 登録日 2022-11-07 公開日 2023-07-05 実験手法 ELECTRON MICROSCOPY (6.95 Å) 主引用文献 Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome. J.Mol.Biol., 435, 2023
6GOU	Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Complex with Inhibitor 2I 分子名称: (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide, Alkyldihydroxyacetonephosphate synthase, peroxisomal, ... 著者 Mattevi, A, Piano, V. 登録日 2018-06-04 公開日 2019-01-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. Eur J Med Chem, 163, 2018
4D2S	Human TTK in complex with a Dyrk1B inhibitor 分子名称: DUAL SPECIFICITY PROTEIN KINASE TTK, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine 著者 Debreczeni, J.E, Kettle, J.G, Ballard, P, Bardelle, C, Butterworth, S, Colclough, N, Critchlow, S.E, Fairley, G, Fillery, S, Graham, M.A, Goodwin, L, Guichard, S, Hudson, K, Mahmood, A, Vincent, J, Ward, R.A, Whittaker, D. 登録日 2014-05-12 公開日 2015-04-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. J.Med.Chem., 58, 2015
4D2R	Human IGF in complex with a Dyrk1B inhibitor 分子名称: CHLORIDE ION, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine 著者 Debreczeni, J.E, Kettle, J.G, Ballard, P, Bardelle, C, Butterworth, S, Colclough, N, Critchlow, S.E, Fairley, G, Fillery, S, Graham, M.A, Goodwin, L, Guichard, S, Hudson, K, Mahmood, A, Vincent, J, Ward, R.A, Whittaker, D. 登録日 2014-05-12 公開日 2015-04-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. J.Med.Chem., 58, 2015
3JB9	Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution 分子名称: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Yan, C, Hang, J, Wan, R, Huang, M, Wong, C, Shi, Y. 登録日 2015-08-09 公開日 2015-09-23 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of a yeast spliceosome at 3.6-angstrom resolution Science, 349, 2015
8J0H	Crystal structure of the fission yeast Rex1BD protein(C4H3.06) 分子名称: Uncharacterized protein C4H3.06 著者 Li, J, Sun, W, Chen, Y. 登録日 2023-04-11 公開日 2023-11-01 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.383 Å) 主引用文献 The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B. Nat Commun, 15, 2024
3VHX	The crystal structure of Arf6-MKLP1 (Mitotic kinesin-like protein 1) complex 分子名称: ADP-ribosylation factor 6, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Makyio, H, Takei, T, Ohgi, H, Takahashi, S, Takatsu, H, Ueda, T, Kanaho, Y, Xie, Y, Shin, H.W, Kamikubo, H, Kataoka, M, Kawasaki, M, Kato, R, Wakatsuki, S, Nakayama, K. 登録日 2011-09-12 公開日 2012-05-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis Embo J., 31, 2012
6IR9	RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-1) of the nucleosome 分子名称: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... 著者 Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2018-11-12 公開日 2019-02-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural insight into nucleosome transcription by RNA polymerase II with elongation factors. Science, 363, 2019
6I8L	Crystal structure of Spindlin1 in complex with the inhibitor TD001851a 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine, ... 著者 Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2018-11-20 公開日 2018-12-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
6INQ	RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome, with foreign DNA (+1 position) 分子名称: DNA (198-MER), DNA (31-MER), DNA-directed RNA polymerase subunit, ... 著者 Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. 登録日 2018-10-26 公開日 2019-04-03 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
6I8Y	Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, ... 著者 Srikannathasan, V, Johansson, C, Gileadi, C, Shrestha, L, Sorrell, F.J, Krojer, T, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2018-11-21 公開日 2018-12-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
5LOH	Kinase domain of human Greatwall 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, STAUROSPORINE, ... 著者 Rajasekaran, M.B, Pearl, L.H, Oliver, A.W. 登録日 2016-08-09 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7, 2016
6I8B	Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn 分子名称: 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone, DIMETHYL SULFOXIDE, GLYCINE, ... 著者 Johansson, C, Fagan, V, Brennan, P.E, Sorrell, F.J, Krojer, T, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U.C.T. 登録日 2018-11-19 公開日 2018-12-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J.Med.Chem., 62, 2019
4E8U	Crystal structure of Arabidopsis IDN2 XS domain along with a small segment of adjacent coiled-coil region 分子名称: Putative uncharacterized protein T8P19.180, SULFATE ION 著者 Simanshu, D.K, Patel, D.J. 登録日 2012-03-20 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis. Proc.Natl.Acad.Sci.USA, 109, 2012
1T2R	Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain 分子名称: 5'-R(*CP*UP*CP*AP*C)-3', Argonaute 2 著者 Lingel, A, Simon, B, Izaurralde, E, Sattler, M. 登録日 2004-04-22 公開日 2004-06-01 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11, 2004
1T2S	Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain 分子名称: 5'-D(*CP*TP*CP*AP*C)-3', Argonaute 2 著者 Lingel, A, Simon, B, Izaurralde, E, Sattler, M. 登録日 2004-04-22 公開日 2004-06-01 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat.Struct.Mol.Biol., 11, 2004
3N3W	2.2 Angstrom Resolution Crystal Structure of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni 分子名称: Ribonuclease III 著者 Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-05-20 公開日 2010-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.205 Å) 主引用文献 2.2 Angstrom Resolution Crystal Structure of Nuclease Domain of Ribonuclase III (rnc) from Campylobacter jejuni TO BE PUBLISHED
7YFX	Cryo-EM structure of Hili in complex with piRNA 分子名称: MAGNESIUM ION, Piwi-like protein 2, piRNA 著者 Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. 登録日 2022-07-09 公開日 2024-01-24 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat.Struct.Mol.Biol., 2024

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