PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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5FGU	Structure of Sda1 nuclease apoprotein as an EGFP fixed-arm fusion 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Green fluorescent protein,Extracellular streptodornase D, ... 著者 Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. 登録日 2015-12-21 公開日 2016-03-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.896 Å) 主引用文献 Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
4ZED	PBP AccA from A. tumefaciens C58 in complex with agrocinopine-3'-O-benzoate 分子名称: 1,2-ETHANEDIOL, ABC transporter, substrate binding protein (Agrocinopines A and B), ... 著者 El Sahili, A, Morera, S. 登録日 2015-04-20 公開日 2015-08-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens. Plos Pathog., 11, 2015
5FIS	Exonuclease domain-containing 1 (Exd1) in the Gd bound conformation 分子名称: EXD1, GADOLINIUM ATOM 著者 Yang, Z, Chen, K.M, Pandey, R.R, Homolka, D, Reuter, M, Rodino Janeiro, B.K, Sachidanandam, R, Fauvarque, M.O, McCarthy, A.A, Pillai, R.S. 登録日 2015-10-02 公開日 2015-12-23 最終更新日 2016-01-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Piwi Slicing and Exd1 Drive Biogenesis of Nuclear Pirnas from Cytosolic Targets of the Mouse Pirna Pathway Mol.Cell, 61, 2016
6TEL	Crystal structure of Dot1L in complex with an inhibitor (compound 10). 分子名称: Histone-lysine N-methyltransferase, H3 lysine-79 specific, POTASSIUM ION, ... 著者 Scheufler, C, Stauffer, F, Be, C, Moebitz, H. 登録日 2019-11-12 公開日 2019-12-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 New Potent DOT1L Inhibitors forin VivoEvaluation in Mouse. Acs Med.Chem.Lett., 10, 2019
6JHA	Crystal structure of NADPH bound AerF from Microcystis aeruginosa 分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short chain dehydrogenase family protein, TRIETHYLENE GLYCOL 著者 Qiu, X. 登録日 2019-02-17 公開日 2019-11-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural and functional investigation of AerF, a NADPH-dependent alkenal double bond reductase participating in the biosynthesis of Choi moiety of aeruginosin J.Struct.Biol., 2019
5HPG	STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN 分子名称: PLASMINOGEN 著者 Tulinsky, A, Mochalkin, I, Castellino, F.J. 登録日 1997-09-19 公開日 1998-03-25 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. Biochemistry, 37, 1998
7BKG	Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (2) 分子名称: 5,6-dihydro-2-imino-2H,4H-thiazolo(5,4,3-IJ)quinoline, Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Schreuder, H.A, Liesum, A. 登録日 2021-01-15 公開日 2021-03-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.326 Å) 主引用文献 Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26, 2021
7BB4	Crystal structure of perdeuterated PLL lectin in complex with L-fucose 分子名称: GLYCEROL, PLL lectin, alpha-L-fucopyranose, ... 著者 Gajdos, L, Blakeley, M.P, Kumar, A, Wimmerova, M, Haertlein, M, Forsyth, V.T, Imberty, A, Devos, J.M. 登録日 2020-12-16 公開日 2021-03-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions. Structure, 29, 2021
5NPL	Crystal structure of hexameric CBS-CP12 protein from bloom-forming cyanobacteria, Yb-derivative at 2.8 A resolution 分子名称: 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, Similar to tr|Q8YYT1|Q8YYT1, YTTERBIUM (III) ION 著者 Hackenberg, C, Hakanpaa, J, Antonyuk, S.V, Dittmann, E, Lamzin, V.S. 登録日 2017-04-17 公開日 2018-05-30 最終更新日 2018-07-11 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NRB	A Native Ternary Complex of Alpha-1,3-Galactosyltransferase (a-3GalT) Supports a Conserved Reaction Mechanism for Retaining Glycosyltransferases - alpha-3GalT in complex with Co2+, UDP-Gal and lactose - a3GalT-Co2+-UDP-Gal-LAT-1 分子名称: COBALT (II) ION, GALACTOSE-URIDINE-5'-DIPHOSPHATE, N-acetyllactosaminide alpha-1,3-galactosyltransferase, ... 著者 Albesa-Jove, D, Marina, A, Sainz-Polo, M.A, Guerin, M.E. 登録日 2017-04-22 公開日 2017-10-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structural Snapshots of alpha-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases. Angew. Chem. Int. Ed. Engl., 56, 2017
6TID	Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with H-type 1 antigen 分子名称: Lectin, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Varrot, A, Bermeo, R. 登録日 2019-11-22 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.614 Å) 主引用文献 BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information. Molecules, 25, 2020
6T5T	Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT 分子名称: 5'-D(*AP*TP*TP*GP*TP*GP*GP*CP*CP*AP*CP*AP*AP*TP)-3', BETA-MERCAPTOETHANOL, CHLORIDE ION, ... 著者 Grazulis, S, Zaremba, M. 登録日 2019-10-17 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7003 Å) 主引用文献 Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT To be published
7BLE	Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (3) 分子名称: 3-ethyl-1,3-diazatricyclo[6.3.1.0^{4,12}]dodeca-4,6,8(12)-trien-2-imine, Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Schreuder, H.A, Liesum, A. 登録日 2021-01-18 公開日 2021-03-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.809 Å) 主引用文献 Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26, 2021
5HDX	BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium 分子名称: 5-[(2E,4aR,7aR)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-2-imino-3-methyl-4-oxooctahydro-7aH-pyrrolo[3,4-d]pyrimidin-7a-yl]thiophene-2-carbonitrile, Beta-secretase 1 著者 Orth, P. 登録日 2016-01-05 公開日 2016-03-16 最終更新日 2016-04-27 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates. J.Med.Chem., 59, 2016
6JKC	Crystal structure of tetrameric PepTSo2 in P4212 space group 分子名称: Proton:oligopeptide symporter POT family 著者 Nagamura, R, Fukuda, M, Ishitani, R, Nureki, O. 登録日 2019-02-28 公開日 2019-05-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2. Acta Crystallogr.,Sect.F, 75, 2019
5HE4	BACE-1 in complex with (4aR,7aS)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2H-pyrrolo[3,4-d]pyrimidin-2-iminium 分子名称: (2E,4aR,7aS)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4H-pyrrolo[3,4-d]pyrimidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID 著者 Orth, P. 登録日 2016-01-05 公開日 2016-03-16 最終更新日 2016-04-27 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates. J.Med.Chem., 59, 2016
7BBC	Joint X-ray/neutron room temperature structure of perdeuterated PLL lectin in complex with perdeuterated L-fucose 分子名称: PLL lectin, alpha-L-fucopyranose, beta-L-fucopyranose 著者 Gajdos, L, Blakeley, M.P, Kumar, A, Wimmerova, M, Haertlein, M, Forsyth, V.T, Imberty, A, Devos, J.M. 登録日 2020-12-17 公開日 2021-03-24 最終更新日 2024-05-01 実験手法 NEUTRON DIFFRACTION (1.84 Å), X-RAY DIFFRACTION 主引用文献 Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions. Structure, 29, 2021
5HU1	BACE1 in complex with (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide 分子名称: Beta-secretase 1, N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide 著者 Orth, P. 登録日 2016-01-27 公開日 2016-11-09 最終更新日 2017-01-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease. J. Med. Chem., 59, 2016
5HUK	The crystal structure of neuraminidase from A/Northern pintail/Washington/40964/2014 influenza virus 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Yang, H, Carney, P.J, Guo, Z, Chang, J.C, Stevens, J. 登録日 2016-01-27 公開日 2016-04-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses. J.Virol., 90, 2016
5NCD	Crystal structure of the polysaccharide deacetylase Bc1974 from Bacillus cereus in complex with (2S)-2-amino-5-(diaminomethylideneamino)-N-hydroxypentanamide 分子名称: ACETATE ION, CITRIC ACID, N-HYDROXY-L-ARGININAMIDE, ... 著者 Giastas, P, Andreou, A, Eliopoulos, E.E. 登録日 2017-03-03 公開日 2018-02-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.447 Å) 主引用文献 Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors. Biochemistry, 57, 2018
6JIR	Crystal structure of C. crescentus beta sliding clamp with PEG bound to putative beta-motif tethering region 分子名称: 1,2-ETHANEDIOL, Beta sliding clamp, DI(HYDROXYETHYL)ETHER, ... 著者 Jiang, X, Teng, M, Li, X. 登録日 2019-02-23 公開日 2019-11-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication. Febs J., 287, 2020
5NFO	Human JMJD7 in complex with Mn and 2OG in the P21212 form 分子名称: 2-OXOGLUTARIC ACID, GLYCEROL, JmjC domain-containing protein 7, ... 著者 Chowdhury, R, Markolovic, S, Schofield, C.J. 登録日 2017-03-14 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.173 Å) 主引用文献 (3S)-Lysyl hydroxylation of TRAFAC GTPases is catalyzed by the human Jumonji-C oxygenase JMJD7. To Be Published
7BG3	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2046 分子名称: 1-(3-bromanyl-4-methyl-phenyl)-2-(2-bromophenyl)imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-05 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
5NG2	Structure of RIP2K(D146N) with bound Staurosporine 分子名称: PHOSPHATE ION, Receptor-interacting serine/threonine-protein kinase 2, STAUROSPORINE 著者 Pellegrini, E, Cusack, S. 登録日 2017-03-16 公開日 2017-06-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation. PLoS ONE, 12, 2017
7BIY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 分子名称: 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-13 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021

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