PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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5CFU	Crystal Structure of ANT(2")-Ia in complex with adenylyl-2"-tobramycin 分子名称: 1,4-BUTANEDIOL, Aminoglycoside Nucleotidyltransferase (2")-Ia, MANGANESE (II) ION, ... 著者 Rodionov, D, Bassenden, A.V, Berghuis, A.M. 登録日 2015-07-08 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Revisiting the Catalytic Cycle and Kinetic Mechanism of AminoglycosideO-Nucleotidyltransferase(2′′): A Structural and Kinetic Study. Acs Chem.Biol., 2020
4AYA	Crystal structure of ID2 HLH homodimer at 2.1A resolution 分子名称: ACETATE ION, DNA-BINDING PROTEIN INHIBITOR ID-2, POTASSIUM ION 著者 Wong, M.V, Jiang, S, Palasingam, P, Kolatkar, P.R. 登録日 2012-06-19 公開日 2012-11-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.103 Å) 主引用文献 A Divalent Ion is Crucial in the Structure and Dominant-Negative Function of Id Proteins, a Class of Helix-Loop-Helix Transcription Regulators. Plos One, 7, 2012
8QU3	NF-YB/C Heterodimer in Complex with a 13-mer NF-YA-derived Peptide Stabilized with C8-Hydrocarbon Linker 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, Nuclear transcription factor Y subunit alpha, ... 著者 Arbore, F, Durukan, C, Klintrot, C.I.R, Grossmann, T.N, Hennig, S. 登録日 2023-10-13 公開日 2024-03-20 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Binding Dynamics of a Stapled Peptide Targeting the Transcription Factor NF-Y. Chembiochem, 25, 2024
8QU2	NF-YB/C Heterodimer in Complex with a 16-mer NF-YA-derived Peptide Stabilized with C8-Hydrocarbon Linker 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, ... 著者 Durukan, C, Arbore, F, Klintrot, C.I.R, Grossmann, T.N, Hennig, S. 登録日 2023-10-13 公開日 2024-03-20 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Binding Dynamics of a Stapled Peptide Targeting the Transcription Factor NF-Y. Chembiochem, 25, 2024
8BFC	Binary structure of 14-3-3s and RND3 phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-10-24 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8C3Z	14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C40	14-3-3sigma bound to PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
5ZMC	Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2 分子名称: DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3'), DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3'), Nuclear factor NF-kappa-B p100 subunit, ... 著者 Xu, X, Bharath, S.R, Song, H. 登録日 2018-04-02 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1. Nat Commun, 9, 2018
8BTQ	Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Pennings, M.A.M, Visser, E.J, Ottmann, C. 登録日 2022-11-29 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BWH	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Pennings, M.A.M, Visser, E.J, Ottmann, C. 登録日 2022-12-06 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BWE	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Visser, E.J, Pennings, M.A.M, Ottmann, C. 登録日 2022-12-06 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
6CP0	SdcA in complex with the E2, UbcH5C 分子名称: SdcA, Ubiquitin-conjugating enzyme E2 D3 著者 Wasilko, D.J, Huang, Q, Mao, Y. 登録日 2018-03-13 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Insights into the ubiquitin transfer cascade catalyzed by theLegionellaeffector SidC. Elife, 7, 2018
1SFV	PORCINE PANCREAS PHOSPHOLIPASE A2, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B, Tessari, M, Boelens, R, Dijkman, R, Kaptein, R, De Haas, G.H, Verheij, H.M. 登録日 1996-02-20 公開日 1996-07-11 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor. J.Biomol.NMR, 5, 1995
1SFW	PORCINE PANCREAS PHOSPHOLIPASE A2, NMR, 18 STRUCTURES 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B, Tessari, M, Boelens, R, Dijkman, R, Kaptein, R, De Haas, G.H, Verheij, H.M. 登録日 1996-02-23 公開日 1996-07-11 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor. J.Biomol.NMR, 5, 1995
2PK2	Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat 分子名称: Cyclin-T1, Protein Tat 著者 Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M. 登録日 2007-04-17 公開日 2007-07-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat. J.Mol.Biol., 370, 2007
2EYZ	CT10-Regulated Kinase isoform II 分子名称: v-crk sarcoma virus CT10 oncogene homolog isoform a 著者 Kobashigawa, Y, Tanaka, S, Inagaki, F. 登録日 2005-11-10 公開日 2006-11-10 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat.Struct.Mol.Biol., 14, 2007
7NMH	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-070 分子名称: (5-methanoyl-2-nitro-phenyl) methanesulfonate, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-23 公開日 2021-09-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6EY7	Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound 分子名称: 4-[(4-fluorophenyl)methyl-methyl-amino]-2,4-bis(oxidanylidene)butanoic acid, CHLORIDE ION, MANGANESE (II) ION, ... 著者 Bongarzone, S, Nadal, M, Kaczmarska, Z, Machon, C, Alvarez, M, Albericio, F, Coll, M. 登録日 2017-11-10 公開日 2018-10-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-Driven Discovery of alpha , gamma-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase. Acs Omega, 3, 2018
7NM3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-135 分子名称: 14-3-3 protein sigma, 4-[4-(dimethylamino)piperidin-1-yl]sulfonylbenzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-23 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NK5	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-124 分子名称: 1-(4-methylphenyl)sulfonyl-4-(2-methylpropyl)piperazine, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-17 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NLE	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-118 分子名称: 14-3-3 protein sigma, 4-(4-methylpiperazin-1-yl)sulfonylbenzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-22 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NM9	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-110 分子名称: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, DI(HYDROXYETHYL)ETHER, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-23 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NM1	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-126 分子名称: 14-3-3 protein sigma, 4-(4-pyrrolidin-1-ylpiperidin-1-yl)sulfonylbenzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-23 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NK3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-128 分子名称: 14-3-3 protein sigma, 2-(4-methylphenyl)sulfonyl-3,4-dihydro-1~{H}-isoquinoline, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-17 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NLA	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-119 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-22 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021

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