PDB: 217477 件ウェブページステータス検索Chemie searchBIRD

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5IRI	Structure of the mouse SAD-B AIS-KA1 fragment 分子名称: Serine/threonine-protein kinase BRSK1 著者 Ma, H, Wu, J.X, Wang, J, Wu, J.W. 登録日 2016-03-13 公開日 2016-06-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and inhibition analysis of the mouse SAD-B C-terminal fragment Biosci.Biotechnol.Biochem., 2016
6RA6	Ferric murine neuroglobin Gly-loop44-47/F106A mutant 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Exertier, C, Freda, I, Montemiglio, L.C, Savino, C, Vallone, B. 登録日 2019-04-05 公開日 2020-03-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy. Febs J., 287, 2020
8WGR	Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition. 分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, POTASSIUM ION, ... 著者 Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. 登録日 2023-09-22 公開日 2024-07-31 最終更新日 2024-08-07 実験手法 ELECTRON MICROSCOPY (2.75 Å) 主引用文献 Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 2024
7ZDB	IF(heme/bound) conformation of CydDC in ADP+Pi(CydC)/ATP(CydD) bound state (Dataset-2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding/permease protein CydC, ... 著者 Wu, D, Safarian, S. 登録日 2022-03-29 公開日 2023-04-19 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nat.Chem.Biol., 19, 2023
7ZDG	IF(heme/confined) conformation of CydDC (Dataset-5) 分子名称: ATP-binding/permease protein CydC, ATP-binding/permease protein CydD, HEME B/C 著者 Wu, D, Safarian, S. 登録日 2022-03-29 公開日 2023-04-19 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nat.Chem.Biol., 19, 2023
7ZDL	IF(heme/coordinated) conformation of CydDC in AMP-PNP(CydC)/AMP-PNP(CydD) bound state (Dataset-8) 分子名称: ATP-binding/permease protein CydC, ATP-binding/permease protein CydD, HEME B/C, ... 著者 Wu, D, Safarian, S. 登録日 2022-03-29 公開日 2023-04-19 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nat.Chem.Biol., 19, 2023
7ZEC	IF(heme/confined) conformation of CydDC in ATP(CydD) bound state (Dataset-15) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding/permease protein CydC, ATP-binding/permease protein CydD, ... 著者 Wu, D, Safarian, S. 登録日 2022-03-30 公開日 2023-04-19 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nat.Chem.Biol., 19, 2023
6TOL	Crystal structure of human BCL6 BTB domain in complex with compound 25a 分子名称: 1,2-ETHANEDIOL, 5-[[5-chloranyl-2-[(2~{S},6~{R})-2,6-dimethylmorpholin-4-yl]pyrimidin-4-yl]amino]-1-methyl-3-(3-methyl-3-oxidanyl-butyl)benzimidazol-2-one, B-cell lymphoma 6 protein, ... 著者 Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. 登録日 2019-12-11 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J.Med.Chem., 63, 2020
7LCY	Crystal structure of the ligand-free ARM domain from Drosophila SARM1 分子名称: Isoform B of NAD(+) hydrolase sarm1 著者 Gu, W, Nanson, J.D, Luo, Z, McGuinness, H.Y, Manik, M.K, Jia, X, Ve, T, Kobe, B. 登録日 2021-01-12 公開日 2021-03-10 最終更新日 2021-04-21 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration. Neuron, 109, 2021
6TOS	Crystal structure of the Orexin-1 receptor in complex with GSK1059865 分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CITRIC ACID, Orexin receptor type 1, ... 著者 Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A. 登録日 2019-12-11 公開日 2020-01-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis. J.Med.Chem., 63, 2020
6G6W	HUMAN PI3KDELTA IN COMPLEX WITH LIGAND LASW1976 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[3-[4-[[(1~{S})-1-(5-methyl-4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7~{H}-pyrrolo[ 2,3-d]pyrimidin-5-yl]-5-oxidanyl-phenyl]methanesulfonamide 著者 Segarra, V, Hernandez, B, Jestel, A, Mortel, M, Nagel, S. 登録日 2018-04-03 公開日 2018-11-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Discovery of a Novel Inhaled PI3K delta Inhibitor for the Treatment of Respiratory Diseases. J. Med. Chem., 61, 2018
8JCC	Human histone H2B variant H2BFWT Cryo-EM structure with 601 DNA sequence 分子名称: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type W-T, ... 著者 Ding, D.B, Ishibashi, T. 登録日 2023-05-10 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 Human histone H2B variant H2BFWT Cryo-EM structure with 601 DNA sequence To Be Published
5V3B	Human A20 OTU domain (WT) with acetamidylated C103 分子名称: Tumor necrosis factor alpha-induced protein 3 著者 Langley, D.B, Christ, D, Grey, S. 登録日 2017-03-07 公開日 2018-03-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat.Immunol., 20, 2019
7LF4	Structure of importin a3 bound to the p50- and p65-NLSs 分子名称: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 著者 Florio, T.J, Lokareddy, R.K, Cingolani, G. 登録日 2021-01-15 公開日 2022-01-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
5VN8	Cryo-EM model of B41 SOSIP.664 in complex with fragment antigen binding variable domain of b12 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Ozorowski, G, Pallesen, J, Ward, A.B, Cottrell, C.A. 登録日 2017-04-28 公開日 2017-07-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature, 547, 2017
7TUK	Small hepatitis B virus surface protein without cytosolic and antigenic loops 分子名称: SAg protein 著者 Liu, H, Wang, J.C.Y. 登録日 2022-02-02 公開日 2022-08-24 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles. Sci Adv, 8, 2022
5JG6	APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C 分子名称: Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION 著者 Brown, N.G, Zhang, W, Yu, S, Miller, D.J, Sidhu, S.S, Schulman, B.A. 登録日 2016-04-19 公開日 2016-06-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.0013 Å) 主引用文献 Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell, 165, 2016
6TOJ	Crystal structure of human BCL6 BTB domain in complex with compound 17a 分子名称: 1,2-ETHANEDIOL, 2-chloranyl-4-[[1-methyl-3-(3-methyl-3-oxidanyl-butyl)-2-oxidanylidene-benzimidazol-5-yl]amino]pyridine-3-carbonitrile, B-cell lymphoma 6 protein 著者 Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. 登録日 2019-12-11 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J.Med.Chem., 63, 2020
6WDC	Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Loveland, A.B, Demo, G, Korostelev, A.A. 登録日 2020-03-31 公開日 2020-07-01 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Nature, 584, 2020
6WDE	Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Loveland, A.B, Demo, G, Korostelev, A.A. 登録日 2020-03-31 公開日 2020-07-01 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Nature, 584, 2020
5VBN	Crystal Structure of human DNA polymerase epsilon B-subunit in complex with C-terminal domain of catalytic subunit 分子名称: DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit 2, SULFATE ION, ... 著者 Baranovskiy, A.G, Gu, J, Suwa, Y, Babayeva, N.D, Tahirov, T.H. 登録日 2017-03-29 公開日 2017-08-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of the human Pol B-subunit in complex with the C-terminal domain of the catalytic subunit. J. Biol. Chem., 292, 2017
1TMN	Binding of n-carboxymethyl dipeptide inhibitors to thermolysin determined by x-ray crystallography. a novel class of transition-state analogues for zinc peptidases 分子名称: CALCIUM ION, N-[(1R)-1-carboxy-3-phenylpropyl]-L-leucyl-L-tryptophan, THERMOLYSIN, ... 著者 Monzingo, A.F, Matthews, B.W. 登録日 1987-06-29 公開日 1989-01-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by X-ray crystallography: a novel class of transition-state analogues for zinc peptidases Biochemistry, 23, 1984
4WSA	Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form) 分子名称: Influenza B vRNA promoter 3' end, Influenza B vRNA promoter 5' end, PA, ... 著者 Reich, S, Guilligay, D, Pflug, A, Cusack, S. 登録日 2014-10-26 公開日 2014-11-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014
6WDG	Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Loveland, A.B, Demo, G, Korostelev, A.A. 登録日 2020-03-31 公開日 2020-07-01 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Nature, 584, 2020
3P2P	ENHANCED ACTIVITY AND ALTERED SPECIFICITY OF PHOSPHOLIPASE A2 BY DELETION OF A SURFACE LOOP 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Dijkstra, B.W, Thunnissen, M.M.G.M, Kalk, K.H, Drenth, J. 登録日 1989-11-29 公開日 1990-01-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop. Science, 244, 1989

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