6G6W

HUMAN PI3KDELTA IN COMPLEX WITH LIGAND LASW1976

Summary for 6G6W

• Entry DOI: 10.2210/pdb6g6w/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, ~{N}-[3-[4-[[(1~{S})-1-(5-methyl-4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7~{H}-pyrrolo[ 2,3-d]pyrimidin-5-yl]-5-oxidanyl-phenyl]methanesulfonamide, ... (4 entities in total)
• Functional Keywords: pi3kdelta kinase, proteros biostructures gmbh, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 144591.98

Authors

Segarra, V.,Hernandez, B.,Jestel, A.,Mortel, M.,Nagel, S. (deposition date: 2018-04-03, release date: 2018-11-07, Last modification date: 2024-01-17)

• Primary citation: Erra, M.,Taltavull, J.,Bernal, F.J.,Caturla, J.F.,Carrascal, M.,Pages, L.,Mir, M.,Espinosa, S.,Gracia, J.,Dominguez, M.,Sabate, M.,Paris, S.,Maldonado, M.,Hernandez, B.,Bravo, M.,Calama, E.,Miralpeix, M.,Lehner, M.D.,Calbet, M.; Discovery of a Novel Inhaled PI3K delta Inhibitor for the Treatment of Respiratory Diseases.; J. Med. Chem., 61:9551-9567, 2018; PubMed: 30351000; DOI: 10.1021/acs.jmedchem.8b00873

Experimental method

X-RAY DIFFRACTION (2.72 Å)