PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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3UXP	Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP 分子名称: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA 5'-D(P*AP*CP*TP*CP*AP*CP*AP*TP*A)-3', DNA 5'-D(P*AP*TP*GP*TP*GP*AP*G)-3', ... 著者 Gridley, C.L, Jaeger, J. 登録日 2011-12-05 公開日 2012-12-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.723 Å) 主引用文献 Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. Biochemistry, 52, 2013
3UXN	Crystal Structure of Rat DNA Polymerase Beta, Wild Type Apoenzyme 分子名称: DNA polymerase beta 著者 Gridley, C.L, Firbank, S, Jaeger, J. 登録日 2011-12-05 公開日 2012-12-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. Biochemistry, 52, 2013
3CFP	Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 1 分子名称: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*DAP*DCP*DAP*DGP*DGP*DTP*DAP*DAP*DGP*DCP*DAP*DGP*DTP*DCP*DCP*DGP*DCP*DG)-3'), ... 著者 Wang, J, Klimenko, D, Wang, M, Steitz, T.A, Konigsberg, W.H. 登録日 2008-03-04 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant To be Published
3UXO	Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme 分子名称: DNA polymerase beta 著者 Gridley, C.L, Jaeger, J. 登録日 2011-12-05 公開日 2012-12-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta. Biochemistry, 52, 2013
6MR7	DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog 分子名称: 1,2-ETHANEDIOL, 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol, CALCIUM ION, ... 著者 Freudenthal, B.D, Smith, M.R, Wilson, S.H, Beard, W.A. 登録日 2018-10-11 公開日 2019-01-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.144 Å) 主引用文献 A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Res., 47, 2019
3QIN	Crystal Structure of HIV-1 RNase H p15 with engineered E. coli loop and pyrimidinol carboxylic acid inhibitor 分子名称: 2-(3-bromo-4-methoxybenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, Fusion protein of HIV-1 RNase H p15 with engineered E. coli loop, MANGANESE (II) ION, ... 著者 Lansdon, E.B, Kirschberg, T.A. 登録日 2011-01-27 公開日 2011-04-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6967 Å) 主引用文献 Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
2V4R	Non-productive complex of the Y-family DNA polymerase Dpo4 with dGTP skipping the M1dG adduct to pair with the next template cytosine 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3', 5'-D(*TP*CP*AP*CP*M1GP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... 著者 Eoff, R.L, Stafford, J.B, Szekely, J, Rizzo, C.J, Egli, M, Guengerich, F.P, Marnett, L.J. 登録日 2008-09-26 公開日 2009-06-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and Functional Analysis of Sulfolobus Solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde-Deoxyguanosine Adduct. Biochemistry, 48, 2009
4DU4	RB69 DNA Polymerase Ternary Complex with dATP Opposite dT with 3-Deaza-adenine at the N-3 Position of Primer Strand 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... 著者 Xia, S, Wang, J, Konigsberg, W.H. 登録日 2012-02-21 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry, 51, 2012
4JV0	Ring-Opening of the -OH-PdG Adduct in Ternary Complexes with the Sulfolobus solfataricus DNA polymerase Dpo4 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*C)-3'), ... 著者 Banerjee, S, Shanmugam, G, Stone, M.P. 登録日 2013-03-25 公開日 2013-08-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Ring-Opening of the gamma-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4. Chem.Res.Toxicol., 26, 2013
4DU1	RB69 DNA Polymerase Ternary Complex with dATP Opposite dT 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... 著者 Xia, S, Wang, J, Konigsberg, W.H. 登録日 2012-02-21 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry, 51, 2012
4E3S	RB69 DNA Polymerase Ternary Complex with dQTP Opposite dT 分子名称: 3-{2-deoxy-5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-7-methyl-3H-imidazo[4,5-b]pyridine, CALCIUM ION, DNA polymerase, ... 著者 Xia, S, Wang, J, Konigsberg, W.H. 登録日 2012-03-10 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry, 51, 2012
8B77	The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active site 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ... 著者 Parkash, V, Johansson, E. 登録日 2022-09-29 公開日 2023-10-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides. Nucleic Acids Res., 2023
5DDY	Binary complex of human Polymerase lambda with dCTP 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase lambda, MAGNESIUM ION, ... 著者 Liu, M.S, Tsai, M.D. 登録日 2015-08-25 公開日 2016-02-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda J.Am.Chem.Soc., 138, 2016
2XGP	Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA 分子名称: 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... 著者 Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T. 登録日 2010-06-07 公開日 2010-11-03 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts. Proc.Natl.Acad.Sci.USA, 107, 2010
2XGQ	Structure of yeast DNA polymerase eta in complex with C8-N-acetyl-2- aminoanthracene containing DNA 分子名称: 5'-D(*CP*8AG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... 著者 Schneider, S, Schorr, S, Carell, T. 登録日 2010-06-07 公開日 2010-11-03 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts. Proc.Natl.Acad.Sci.USA, 107, 2010
1NGM	Crystal structure of a yeast Brf1-TBP-DNA ternary complex 分子名称: 5'-D(*AP*AP*AP*AP*AP*AP*CP*AP*TP*TP*TP*TP*TP*TP*TP*AP*TP*AP*G)-3', 5'-D(*CP*TP*AP*TP*AP*AP*AP*AP*AP*AP*AP*TP*GP*TP*TP*TP*TP*TP*T)-3', Transcription factor IIIB BRF1 subunit, ... 著者 Juo, Z.S, Kassavetis, G.A, Wang, J, Geiduschek, E.P, Sigler, P.B. 登録日 2002-12-17 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structure of a transcription factor IIIB core interface ternary complex Nature, 422, 2003
4YQW	Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P. 登録日 2015-03-13 公開日 2015-05-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.064 Å) 主引用文献 Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. J.Biol.Chem., 290, 2015
6MR8	D276G DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog 分子名称: 1,2-ETHANEDIOL, 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol, CALCIUM ION, ... 著者 Freudenthal, B.D, Smith, M.R, Wilson, S.H, Beard, W.A. 登録日 2018-10-11 公開日 2019-01-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Res., 47, 2019
4MF2	Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA 分子名称: DNA polymerase beta, SODIUM ION, synthetic downstream primer, ... 著者 Koag, M.C, Min, K, Monzingo, A.F, Lee, S. 登録日 2013-08-27 公開日 2014-04-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136, 2014
3IKM	Crystal structure of human mitochondrial DNA polymerase holoenzyme 分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2 著者 Lee, Y.-S, Kennedy, W.D, Yin, Y.W. 登録日 2009-08-06 公開日 2009-11-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Cell(Cambridge,Mass.), 139, 2009
5U2R	PRECATALYTIC TERNARY COMPLEX OF HUMAN DNA POLYMERASE BETA WITH GAPPED DNA SUBSTARTE, INCOMING L-DCTP AND CA2+ 分子名称: 10- MER PRIMER, 16- MER TEMPLATE, 4-amino-1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}pyrimidin-2(1H)-one, ... 著者 Vyas, R, Suo, Z. 登録日 2016-11-30 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the D-stereoselectivity of human DNA polymerase beta. Nucleic Acids Res., 45, 2017
5U2T	Pre-catalytic ternary complex of Human DNA Polymerase Beta With Gapped DNA substrate incoming (-)FTC-TP and Ca2+. 分子名称: 10- MER PRIMER, 16- MER TEMPLATE, 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER, ... 著者 Vyas, R, Suo, Z. 登録日 2016-11-30 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural basis for the D-stereoselectivity of human DNA polymerase beta. Nucleic Acids Res., 45, 2017
5U2S	Pre-catalytic ternary complex of Human DNA Polymerase Beta With Gapped DNA substrate incoming (-)3TC-TP and Ca2+. 分子名称: 10- MER PRIMER, 16- MER TEMPLATE, 5-MER PHOSPHORYLATED DOWNSTREAM PRIMER, ... 著者 Vyas, R, Suo, Z. 登録日 2016-11-30 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the D-stereoselectivity of human DNA polymerase beta. Nucleic Acids Res., 45, 2017
4MFC	Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable CTP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA polymerase beta, MAGNESIUM ION, ... 著者 Koag, M.C, Min, K, Monzingo, A.F, Lee, S. 登録日 2013-08-27 公開日 2014-04-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136, 2014
4MFF	Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable TTP 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA polymerase beta, MAGNESIUM ION, ... 著者 Koag, M.C, Min, K, Monzingo, A.F, Lee, S. 登録日 2013-08-27 公開日 2014-04-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136, 2014

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