9ARE
 
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation | | 分子名称: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | | 著者 | Chou, T.-H, Furukawa, H. | | 登録日 | 2024-02-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9ARF
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in nonactive1 conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Chou, T.-H, Furukawa, H. | | 登録日 | 2024-02-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9B6A
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9B67
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9BIB
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation, C1 symmetry | | 分子名称: | GLUTAMIC ACID, GLYCINE, Glutamate receptor, ... | | 著者 | Chou, T.-H, Furukawa, H. | | 登録日 | 2024-04-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9ARH
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9B69
 | | GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | | 著者 | Nakagawa, T, Greger, I.H. | | 登録日 | 2024-03-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | | 主引用文献 | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization.
Nat.Struct.Mol.Biol., 2024
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9B68
 | | GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | | 著者 | Nakagawa, T, Greger, I.H. | | 登録日 | 2024-03-23 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization.
Nat.Struct.Mol.Biol., 2024
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8USX
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8UUE
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3H06
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8VJ7
 | | GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2 | | 分子名称: | 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2 | | 著者 | Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. | | 登録日 | 2024-01-05 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.85 Å) | | 主引用文献 | Allosteric competition and inhibition in AMPA receptors.
Nat.Struct.Mol.Biol., 2024
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8VJ6
 | | GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1 | | 分子名称: | 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, Isoform Flip of Glutamate receptor 2 | | 著者 | Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. | | 登録日 | 2024-01-05 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Allosteric competition and inhibition in AMPA receptors.
Nat.Struct.Mol.Biol., 2024
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3H03
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3H6W
 | | Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution | | 分子名称: | (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... | | 著者 | Hald, H, Gajhede, M, Kastrup, J.S. | | 登録日 | 2009-04-24 | | 公開日 | 2009-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
J.Mol.Biol., 391, 2009
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3IL1
 | | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 | | 分子名称: | (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | | 著者 | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | | 登録日 | 2009-08-06 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
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3ILT
 | | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide | | 分子名称: | 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... | | 著者 | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | | 登録日 | 2009-08-07 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.107 Å) | | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
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3IK6
 | | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide | | 分子名称: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | | 著者 | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | | 登録日 | 2009-08-05 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
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3IJO
 | | Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide | | 分子名称: | (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | | 著者 | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | | 登録日 | 2009-08-04 | | 公開日 | 2009-09-15 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
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8VUN
 | | Human GluN1-2A With Fab 008-218 | | 分子名称: | 008-218 Heavy, 008-218 Light, Glutamate receptor ionotropic, ... | | 著者 | Michalski, K, Furukawa, H. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | | 主引用文献 | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUH
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8VUJ
 | | Human GluN1-2A with Fab 003-102 | | 分子名称: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | | 著者 | Michalski, K, Furukawa, H. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | | 主引用文献 | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUU
 | | Human GluN1-2B with Fab 007-168 | | 分子名称: | 007-168 Heavy, 007-168 Light, Glutamate receptor ionotropic, ... | | 著者 | Michalski, K, Furukawa, H. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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8VUR
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8VUT
 | | Human GluN1-2A with IgG 008-218 | | 分子名称: | 008-218 Heavy, 008-218 Light, Glutamate receptor ionotropic, ... | | 著者 | Michalski, K, Furukawa, H. | | 登録日 | 2024-01-29 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis.
Nat.Struct.Mol.Biol., 2024
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