PDB: 22634 件ウェブページステータス検索Chemie searchBIRD

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7SF5	M. tb EgtD in complex with HD3 分子名称: Histidine N-alpha-methyltransferase, N-(benzylcarbamothioyl)-L-histidine 著者 Sudasinghe, T.D, Ronning, D.R. 登録日 2021-10-03 公開日 2021-12-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. Sci Rep, 11, 2021
7SF4	M. tb EgtD in complex with imatinib 分子名称: 1,2-ETHANEDIOL, 2-AMINO-4-PYRIDYL-PYRIMIDINE, GLYCEROL, ... 著者 Sudasinghe, T.D, Ronning, D.R. 登録日 2021-10-03 公開日 2021-12-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. Sci Rep, 11, 2021
7SCF	M. tb EgtD in complex with HD2 分子名称: (2S)-3-(1H-imidazol-5-yl)-2-(1H-pyrrol-1-yl)propanoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Sudasinghe, T.D, Ronning, D.R. 登録日 2021-09-28 公開日 2021-12-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. Sci Rep, 11, 2021
7Q52	Crystal structure of S/T protein kinase PknG from Mycobacterium tuberculosis in complex with inhibitor L2W 分子名称: 2-azanyl-3-(4-fluorophenyl)carbonyl-indolizine-1-carboxamide, FE (III) ION, SODIUM ION, ... 著者 Defelipe, L.A, Burastero, O, Bento, I, Garcia-Alai, M.M. 登録日 2021-11-02 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors. J.Med.Chem., 65, 2022
7F70	Crystal structure of Rv3094c 分子名称: Rv3094c 著者 Wang, Z.X, Ouyang, S.Y, Zhang, H.T. 登録日 2021-06-26 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol, 6, 2023
7F74	Rv3094c in complex with FMN. 分子名称: FLAVIN MONONUCLEOTIDE, Rv3094c 著者 Wang, Z.X, Ouyang, S.Y. 登録日 2021-06-27 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol, 6, 2023
5TCG	Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form 分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CESIUM ION, FORMIC ACID, ... 著者 Michalska, K, Maltseva, N, Jedrzejczak, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-09-15 公開日 2017-05-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol., 13, 2017
7F72	Rv3094c in complex with FAD and ETH. 分子名称: 2-ethylpyridine-4-carboximidothioic acid, FLAVIN MONONUCLEOTIDE, Rv3094c 著者 Wang, Z.X, Ouyang, S.Y. 登録日 2021-06-27 公開日 2022-07-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. Commun Biol, 6, 2023
5TCF	Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form 分子名称: FORMIC ACID, MALONATE ION, POTASSIUM ION, ... 著者 Michalska, K, Maltseva, N, Jedrzejczak, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-09-15 公開日 2017-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol., 13, 2017
7RJ3	Crystal Structure of the Forkhead Associated (FHA) Domain of the Glycogen Accumulation Regulator (GarA) from Mycobacterium tuberculosis 分子名称: DI(HYDROXYETHYL)ETHER, Glycogen accumulation regulator GarA 著者 Minasov, G, Shuvalova, L, Pshenychnyi, S, Dubrovska, I, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-07-20 公開日 2021-07-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystal Structure of the Forkhead Associated (FHA) Domain of the Glycogen Accumulation Regulator (GarA) from Mycobacterium tuberculosis. To Be Published
5TCH	Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form, TrpA-G66V mutant 分子名称: FORMIC ACID, MALONATE ION, Tryptophan synthase alpha chain, ... 著者 Michalska, K, Maltseva, N, Jedrzejczak, R, Wellington, S, Nag, P.P, Fisher, S.L, Schreiber, S.L, Hung, D.T, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-09-15 公開日 2017-05-31 最終更新日 2022-04-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol., 13, 2017
5TCJ	Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form 分子名称: (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CESIUM ION, ... 著者 Michalska, K, Maltseva, N, Jedrzejczak, R, Wellington, S, Nag, P.P, Fisher, S.L, Schreiber, S.L, Hung, D.T, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-09-15 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol., 13, 2017
7S5N	Crystal Structure of a Putative uncharacterized protein from Mycobacterium marinum 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, MymaA.17060.a, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-09-10 公開日 2021-09-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of a Putative uncharacterized protein from Mycobacterium marinum to be published
7N6B	Structure of MmpL3 reconstituted into lipid nanodisc in the TMM bound state 分子名称: 6-O-[(2S)-2-{(1S)-18-[(1R,2R)-2-hexylcyclopropyl]-1-hydroxyoctadecyl}tricosanoyl]-alpha-D-glucopyranosyl alpha-D-glucopyranoside, MmpL3 transporter 著者 Su, C.C, Yu, E. 登録日 2021-06-08 公開日 2021-09-01 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.66 Å) 主引用文献 Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport. Plos Biol., 19, 2021
5TCI	Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form 分子名称: (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile, FORMIC ACID, MALONATE ION, ... 著者 Michalska, K, Maltseva, N, Jedrzejczak, R, Wellington, S, Nag, P.P, Fisher, S.L, Schreiber, S.L, Hung, D.T, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2016-09-15 公開日 2017-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol., 13, 2017
6GAU	Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert 分子名称: DNA gyrase subunit B,DNA gyrase subunit A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Petrella, S, Capton, E, Alzari, P.M, Aubry, A, Mayer, C. 登録日 2018-04-12 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity. Structure, 27, 2019
5OEQ	Mycobacterium tuberculosis DprE1 in complex with inhibitor TCA020 分子名称: Decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ... 著者 Futterer, K, Batt, S.M, Besra, G.S. 登録日 2017-07-09 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes. Angew. Chem. Int. Ed. Engl., 56, 2017
3MGX	Crystal Structure of P450 OxyD that is involved in the Biosynthesis of Vancomycin-type Antibiotics 分子名称: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative P450 monooxygenase 著者 Cryle, M.J, Schlichting, I. 登録日 2010-04-07 公開日 2010-06-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural characterization of oxyd, a cytochrome p450 involved in {beta}-hydroxytyrosine formation in vancomycin biosynthesis J.Biol.Chem., 285, 2010
7PHM	Cryo-EM structure of Mycobacterium tuberculosis encapsulin 分子名称: 29 kDa antigen CFP29 著者 Woodward, J.D. 登録日 2021-08-17 公開日 2022-07-20 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.2 Å) 主引用文献 Cryo-EM structure of Mycobacterium tuberculosis encapsulin To Be Published
7SZV	Crystal Structure of Acyl-CoA dehydrogenase from Mycobacterium marinum in complex with FDA 分子名称: Acyl-CoA dehydrogenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-11-29 公開日 2021-12-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Acyl-CoA dehydrogenase from Mycobacterium marinum in complex with FDA to be published
7F5Y	Crystal structure of the single-stranded dna-binding protein from Mycobacterium tuberculosis- Form III 分子名称: FORMIC ACID, Single-stranded DNA-binding protein 著者 Srikalaivani, R, Paul, A, Sriram, R, Narayanan, S, Gopal, B, Vijayan, M. 登録日 2021-06-23 公開日 2022-05-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structural variability of Mycobacterium tuberculosis SSB and susceptibility to inhibition. Curr.Sci., 122, 2022
7F5Z	Crystal structure of the single-stranded dna-binding protein from Mycobacterium tuberculosis- Form III 分子名称: Single-stranded DNA-binding protein 著者 Srikalaivani, R, Paul, A, Sriram, R, Narayanan, S, Gopal, B, Vijayan, M. 登録日 2021-06-23 公開日 2022-05-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural variability of Mycobacterium tuberculosis SSB and susceptibility to inhibition. Curr.Sci., 122, 2022
7FHP	Crystal structure of an orphan heme uptake protein (MhuP) of ABC transporter from Mycobacterium tuberculosis (Form II) 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Probable periplasmic iron-transport lipoprotein, ... 著者 Mandal, S.K, Kanaujia, S.P. 登録日 2021-07-29 公開日 2022-06-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Role of an orphan substrate-binding protein MhuP in transient heme transfer in Mycobacterium tuberculosis Int.J.Biol.Macromol., 211, 2022
7FHM	Crystal structure of an orphan heme uptake protein (MhuP) of ABC transporter from Mycobacterium tuberculosis (Form I) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CARBON DIOXIDE, ... 著者 Mandal, S.K, Kanaujia, S.P. 登録日 2021-07-29 公開日 2022-06-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Role of an orphan substrate-binding protein MhuP in transient heme transfer in Mycobacterium tuberculosis Int.J.Biol.Macromol., 211, 2022
6BGL	Doubly PafE-capped 20S core particle in Mycobacterium tuberculosis 分子名称: Bacterial proteasome activator, Proteasome subunit alpha, Proteasome subunit beta 著者 Li, H, Hu, K. 登録日 2017-10-28 公開日 2018-02-14 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Proteasome substrate capture and gate opening by the accessory factor PafE fromMycobacterium tuberculosis. J. Biol. Chem., 293, 2018

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