7SCF

M. tb EgtD in complex with HD2

Summary for 7SCF

Entry DOI	10.2210/pdb7scf/pdb
Descriptor	Histidine N-alpha-methyltransferase, (2S)-3-(1H-imidazol-5-yl)-2-(1H-pyrrol-1-yl)propanoic acid, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	ergothioneine biosynthesis pathway, rossmann fold domain, histidine/histamine derivatives, sam dependent methyltransferase, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	72489.36
Authors	Sudasinghe, T.D.,Ronning, D.R. (deposition date: 2021-09-28, release date: 2021-12-01, Last modification date: 2023-10-18)
Primary citation	Sudasinghe, T.D.,Banco, M.T.,Ronning, D.R. Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. Sci Rep, 11:22240-22240, 2021 Cited by PubMed: 34782676 DOI: 10.1038/s41598-021-01526-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation