PDB: 47120 件ウェブページステータス検索Chemie searchBIRD

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4KYW	Restriction endonuclease DPNI in complex with two DNA molecules 分子名称: 5'-(*DC*DTP*DGP*DGP*6MAP*DTP*DCP*DCP*DAP*DG)-3', CALCIUM ION, SODIUM ION, ... 著者 Mierzejewska, K, Siwek, W, Czapinska, H, Skowronek, K, Bujnicki, J.M, Bochtler, M. 登録日 2013-05-29 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis of the methylation specificity of R.DpnI. Nucleic Acids Res., 42, 2014
6G60	Choline sulfatase from Ensifer (Sinorhizobium) meliloti cocrystalized with choline 分子名称: CHOLINE ION, Choline-sulfatase, MAGNESIUM ION, ... 著者 Martinez-Rodriguez, S, Camara-Artigas, A. 登録日 2018-03-30 公開日 2019-04-10 最終更新日 2023-03-08 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding. Acta Crystallogr D Struct Biol, 78, 2022
7O0L	Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093) 分子名称: 4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Dolbois, A, Caflisch, A. 登録日 2021-03-26 公開日 2021-09-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021
4L6I	Methylthioadenosine phosphorylase from Schistosoma mansoni in complex with adenine 分子名称: ADENINE, S-methyl-5'-thioadenosine phosphorylase, SULFATE ION 著者 Torini, J.R, DeMarco, R, Brandao-Neto, J, Pereira, H.M. 登録日 2013-06-12 公開日 2014-06-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway. Plos Negl Trop Dis, 10, 2016
7O20	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Brandstetter, H. 登録日 2021-03-30 公開日 2021-09-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
7O29	Crystal structure of the human METTL3-METTL14 complex bound to Compound 20 (ADO_AD_044) 分子名称: 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-fluoranyl-phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Dolbois, A, Caflisch, A. 登録日 2021-03-30 公開日 2021-09-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021
6G87	Flavonoid-responsive Regulator FrrA 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, TetR/AcrR family transcriptional regulator 著者 Werner, N, Hoppen, J, Palm, G, Werten, S, Goettfert, M, Hinrichs, W. 登録日 2018-04-07 公開日 2019-04-24 最終更新日 2021-08-18 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 The induction mechanism of the flavonoid-responsive regulator FrrA. Febs J., 2021
4L7D	Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid 分子名称: (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1 著者 Jnoff, E, Brookfield, F, Albrecht, C, Barker, J.J, Barker, O, Beaumont, E, Bromidge, S, Brooks, M, Ceska, T, Courade, J.P, Crabbe, T, Duclos, S, Fryatt, T, Jigorel, E, Kwong, J, Sands, Z, Smith, M.A. 登録日 2013-06-13 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. Chemmedchem, 9, 2014
7NWJ	Solution NMR structure of the N-terminal domain of CEP164 (1-109) 分子名称: Centrosomal protein of 164 kDa 著者 van Breugel, M, Rutherford, T.J. 登録日 2021-03-16 公開日 2021-09-15 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies. Structure, 30, 2022
7O2H	Crystal structure of the human METTL3-METTL14 complex bound to Compound 13 (ADO_AD_091) 分子名称: 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1-methyl-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... 著者 Bedi, R.K, Dolbois, A, Caflisch, A. 登録日 2021-03-30 公開日 2021-09-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the human METTL3-METTL14 complex bound to Compound 13 (ADO_AD_091) To Be Published
4KUP	Endothiapepsin in complex with 20mM acylhydrazone inhibitor 分子名称: (2S)-2-azanyl-3-(3H-indol-3-yl)-N-[(E)-(2,4,6-trimethylphenyl)methylideneamino]propanamide, ACETATE ION, DIMETHYL SULFOXIDE, ... 著者 Radeva, N, Heine, A, Klebe, G. 登録日 2013-05-22 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.311 Å) 主引用文献 Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry. Angew.Chem.Int.Ed.Engl., 53, 2014
8G55	Temperature-dependent structures of tau aggregates 分子名称: Microtubule-associated protein tau 著者 El Mammeri, N, Duan, P, Dregni, A.J, Hong, M. 登録日 2023-02-11 公開日 2023-06-07 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 Amyloid fibril structures of tau: Conformational plasticity of the second microtubule-binding repeat. Sci Adv, 9, 2023
6FV8	Dimer structure of the MATE family multidrug resistance transporter Aq_128 from Aquifex aeolicus in the outward-facing state 分子名称: Aq128 著者 Zhao, J, Safarian, S, Thielmann, Y, Xie, H, Wang, J, Michel, H. 登録日 2018-03-01 公開日 2019-03-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Dimer structure of the MATE family multidrug resistance transporter Aq128 in the outward-facing state To Be Published
8GH9	Cryo-EM structure of hSlo1 in total membrane vesicles 分子名称: Calcium-activated potassium channel subunit alpha-1 著者 Tao, X, Zhao, C, MacKinnon, R. 登録日 2023-03-09 公開日 2023-05-10 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proc.Natl.Acad.Sci.USA, 120, 2023
8G54	Temperature-dependent structures of tau aggregates 分子名称: Microtubule-associated protein tau 著者 El Mammeri, N, Duan, P, Dregni, A.J, Hong, M. 登録日 2023-02-11 公開日 2023-06-07 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 Amyloid fibril structures of tau: Conformational plasticity of the second microtubule-binding repeat. Sci Adv, 9, 2023
7O49	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, CHLORIDE ION, ... 著者 Martinez Caballero, S, Hermoso, J.A. 登録日 2021-04-05 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
4KY5	Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D at pH 7 and cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Robinson, A.C, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2013-05-28 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D at pH 7 and cryogenic temperature To be Published
6FOZ	The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 13 分子名称: 5-(3,4-dichlorophenyl)furan-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase 著者 Levy, C.W, Leys, D. 登録日 2018-02-08 公開日 2019-08-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol, 2, 2019
6FQB	MurT/GatD peptidoglycan amidotransferase complex from Streptococcus pneumoniae R6 分子名称: Cobyric acid synthase, GLUTAMINE, Mur ligase family protein 著者 Morlot, C, Contreras-Martel, C, Leisico, F, Straume, D, Peters, K, Hegnar, O.A, Simon, N, Villard, A.M, Breukink, E, Gravier-Pelletier, C, Le Corre, L, Vollmer, W, Pietrancosta, N, Havarstein, L.S, Zapun, A. 登録日 2018-02-13 公開日 2018-08-22 最終更新日 2018-11-07 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae. Nat Commun, 9, 2018
8TJN	Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ... 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-07-23 公開日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
4L0U	Crystal structure of Plasmodium vivax Prx1a 分子名称: 2-Cys peroxiredoxin, putative, ACETATE ION 著者 Gretes, M.C, Karplus, P.A. 登録日 2013-06-01 公開日 2016-11-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Observed octameric assembly of a Plasmodium yoelii peroxiredoxin can be explained by the replacement of native "ball-and-socket" interacting residues by an affinity tag. Protein Sci., 22, 2013
7NTF	Cryo-EM structure of unliganded O-GlcNAc transferase 分子名称: Isoform 1 of UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 著者 Meek, R.W, Blaza, J.N, Davies, G.J. 登録日 2021-03-09 公開日 2021-11-17 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (5.32 Å) 主引用文献 Cryo-EM structure provides insights into the dimer arrangement of the O-linked beta-N-acetylglucosamine transferase OGT. Nat Commun, 12, 2021
8TPX	Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 3 in complex with antibody fragment 1B2: trans-oriented 1B2 and ACP 分子名称: Antibody Fragment 1B2, Heavy Chain, Light Chain, ... 著者 Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. 登録日 2023-08-05 公開日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis To Be Published
8TOZ	Class III PreQ1 riboswitch double mutant U8C/A85G 分子名称: 7-DEAZA-7-AMINOMETHYL-GUANINE, Class-III preQ1 riboswitch 著者 Srivastava, Y, Jenkins, J.L, Wedekind, J.E. 登録日 2023-08-04 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 New insights into Class III PreQ1 metabolite binding To Be Published
4L37	SP2-SP3 - a complex of two storage proteins from Bombyx mori hemolymph 分子名称: Arylphorin, SODIUM ION, SULFATE ION, ... 著者 Pietrzyk, A.J, Bujacz, A, Mueller-Dieckmann, J, Jaskolski, M, Bujacz, G. 登録日 2013-06-05 公開日 2013-12-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystallographic identification of an unexpected protein complex in silkworm haemolymph. Acta Crystallogr.,Sect.D, 69, 2013

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