8IFD
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![BU of 8ifd by Molmil](/molmil-images/mine/8ifd) | Dibekacin-added human 80S ribosome | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. | 登録日 | 2023-02-17 | 公開日 | 2024-02-14 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. J.Biochem., 175, 2024
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4QTD
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![BU of 4qtd by Molmil](/molmil-images/mine/4qtd) | Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode | 分子名称: | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Chaikuad, A, Keates, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2014-07-07 | 公開日 | 2014-07-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nat.Chem.Biol., 10, 2014
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4U79
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![BU of 4u79 by Molmil](/molmil-images/mine/4u79) | Crystal structure of human JNK3 in complex with a benzenesulfonamide inhibitor. | 分子名称: | Mitogen-activated protein kinase 10, N-{4-[(3-{2-[(trans-4-aminocyclohexyl)amino]pyrimidin-4-yl}pyridin-2-yl)oxy]naphthalen-1-yl}benzenesulfonamide | 著者 | Mohr, C. | 登録日 | 2014-07-30 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Unfolded Protein Response in Cancer: IRE1 alpha Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability. Acs Med.Chem.Lett., 6, 2015
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6BE0
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![BU of 6be0 by Molmil](/molmil-images/mine/6be0) | AvrA delL154 with IP6, CoA | 分子名称: | AvrA, COENZYME A, INOSITOL HEXAKISPHOSPHATE | 著者 | Labriola, J.M, Nagar, B. | 登録日 | 2017-10-24 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | 主引用文献 | Structural Analysis of the Bacterial Effector AvrA Identifies a Critical Helix Involved in Substrate Recognition. Biochemistry, 57, 2018
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6RFO
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![BU of 6rfo by Molmil](/molmil-images/mine/6rfo) | ERK2 MAP kinase with the activation loop of p38alpha | 分子名称: | Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 14,Mitogen-activated protein kinase 1 | 著者 | Livnah, O, Eitan-Wexler, M. | 登録日 | 2019-04-15 | 公開日 | 2020-05-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop. J.Biol.Chem., 295, 2020
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4GLQ
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![BU of 4glq by Molmil](/molmil-images/mine/4glq) | Crystal Structure of the blue-light absorbing form of the Thermosynechococcus elongatus PixJ GAF-domain | 分子名称: | Methyl-accepting chemotaxis protein, Phycoviolobilin, blue light-absorbing form | 著者 | Burgie, E.S, Walker, J.M, Phillips Jr, G.N, Vierstra, R.D. | 登録日 | 2012-08-14 | 公開日 | 2013-01-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.772 Å) | 主引用文献 | A Photo-Labile Thioether Linkage to Phycoviolobilin Provides the Foundation for the Blue/Green Photocycles in DXCF-Cyanobacteriochromes. Structure, 21, 2013
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4GK0
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![BU of 4gk0 by Molmil](/molmil-images/mine/4gk0) | Crystal structure of human Rev3-Rev7-Rev1 complex | 分子名称: | DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B | 著者 | Tao, J, Min, X, Wei, X. | 登録日 | 2012-08-10 | 公開日 | 2013-03-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
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4GMI
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![BU of 4gmi by Molmil](/molmil-images/mine/4gmi) | BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571 | 分子名称: | (4S,8E)-4-[(1R)-2-{[2-(5-tert-butyl-1,3-oxazol-2-yl)propan-2-yl]amino}-1-hydroxyethyl]-16-methyl-6-oxa-3-azabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraene-2,13-dione, ACETATE ION, Beta-secretase 1, ... | 著者 | Lindberg, J.D, Derbyshire, D. | 登録日 | 2012-08-16 | 公開日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design and synthesis of novel BACE-1 inhibitors To be Published
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4G8J
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![BU of 4g8j by Molmil](/molmil-images/mine/4g8j) | X-ray Structure of Uridine Phosphorylease from Vibrio cholerae Complexed with Thymidine at 2.12 A Resolution | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Lashkov, A.A, Gabdoulkhakov, A.G, Prokofev, I.I, Sotnichenko, S.E, Betzel, C, Mikhailov, A.M. | 登録日 | 2012-07-23 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.119 Å) | 主引用文献 | X-ray structure of uridine phosphorylease from Vibrio cholerae complexed with thymidine To be Published
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4GLV
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![BU of 4glv by Molmil](/molmil-images/mine/4glv) | OBody AM3L09 bound to hen egg-white lysozyme | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Lysozyme C, ... | 著者 | Steemson, J.D. | 登録日 | 2012-08-15 | 公開日 | 2013-08-21 | 最終更新日 | 2014-02-12 | 実験手法 | X-RAY DIFFRACTION (2.574 Å) | 主引用文献 | Tracking Molecular Recognition at the Atomic Level with a New Protein Scaffold Based on the OB-Fold. Plos One, 9, 2014
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4GK5
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![BU of 4gk5 by Molmil](/molmil-images/mine/4gk5) | Crystal structure of human Rev3-Rev7-Rev1-Polkappa complex | 分子名称: | DNA polymerase kappa, DNA polymerase zeta catalytic subunit, DNA repair protein REV1, ... | 著者 | Tao, J, Min, X, Wei, X. | 登録日 | 2012-08-10 | 公開日 | 2013-03-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Structural insights into the assembly of human translesion polymerase complexes Protein Cell, 3, 2012
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4GN5
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![BU of 4gn5 by Molmil](/molmil-images/mine/4gn5) | |
4GN4
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![BU of 4gn4 by Molmil](/molmil-images/mine/4gn4) | |
4GNV
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6T3H
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6T46
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![BU of 6t46 by Molmil](/molmil-images/mine/6t46) | Structure of the Rap conjugation gene regulator of the plasmid pLS20 in complex with the Phr* peptide | 分子名称: | CHLORIDE ION, Quorum-sensing secretion protein (processed), Response regulator aspartate phosphatase, ... | 著者 | Crespo, I, Bernardo, N, Meijer, W.J.J, Boer, D.R. | 登録日 | 2019-10-12 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Inactivation of the dimeric RappLS20 anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization. Nucleic Acids Res., 48, 2020
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2WF4
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![BU of 2wf4 by Molmil](/molmil-images/mine/2wf4) | Human BACE-1 in complex with 6-ethyl-1-methyl-N-((1S)-2-oxo-1-(phenylmethyl)-3-(tetrahydro-2H-pyran-4-ylamino)propyl)-1,3,4,6- tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide | 分子名称: | BETA-SECRETASE 1, N-[(1S)-1-BENZYL-2,2-DIHYDROXY-3-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PROPYL]-6-ETHYL-1-METHYL-1,3,4,6-TETRAHYDRO[1,2]THIAZEPINO[5,4,3-CD]INDOLE-8-CARBOXAMIDE 2,2-DIOXIDE | 著者 | Charrier, N, Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, Hawkins, J, Howes, C, Hubbard, J, Hussain, I, Maile, G, Matico, R, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G. | 登録日 | 2009-04-02 | 公開日 | 2009-05-12 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Second Generation of Bace-1 Inhibitors Part 3: Towards Non Hydroxyethylamine Transition State Mimetics. Bioorg.Med.Chem.Lett., 19, 2009
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6TXF
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![BU of 6txf by Molmil](/molmil-images/mine/6txf) | Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mn | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. | 登録日 | 2020-01-14 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
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4ZK0
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![BU of 4zk0 by Molmil](/molmil-images/mine/4zk0) | Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure | 分子名称: | Serpin B4, ZINC ION | 著者 | Helland, R, Lysvand, H, Slupphaug, G, Iversen, O.J. | 登録日 | 2015-04-29 | 公開日 | 2015-07-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates. Biochem Biophys Rep, 2, 2015
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4ZK3
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3VVB
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![BU of 3vvb by Molmil](/molmil-images/mine/3vvb) | Crystal Structure of Capsular Polysaccharide Synthesizing Enzyme CapE from Staphylococcus aureus in apo form | 分子名称: | CapE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Miyafusa, T, Caaveiro, J.M, Tanaka, Y, Tsumoto, K. | 登録日 | 2012-07-18 | 公開日 | 2013-06-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus. Biosci.Rep., 33, 2013
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7SFT
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![BU of 7sft by Molmil](/molmil-images/mine/7sft) | Filamin complex-2 | 分子名称: | Filamin-A, Integrin alpha-IIb light chain, form 2 | 著者 | Liu, J, Qin, J. | 登録日 | 2021-10-04 | 公開日 | 2023-04-12 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage. Blood, 141, 2023
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7SC4
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![BU of 7sc4 by Molmil](/molmil-images/mine/7sc4) | filamin complex-1 | 分子名称: | Filamin-A/Integrin alpha-IIb light chain, form 2 chimera, SULFATE ION | 著者 | Liu, J, Qin, J. | 登録日 | 2021-09-27 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage. Blood, 141, 2023
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3VTM
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![BU of 3vtm by Molmil](/molmil-images/mine/3vtm) | Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin | 分子名称: | GLYCEROL, Iron-regulated surface determinant protein H, PROTOPORPHYRIN IX CONTAINING INDIUM | 著者 | Vu, N.T, Caaveiro, J.M.M, Moriwaki, Y, Tsumoto, K. | 登録日 | 2012-05-31 | 公開日 | 2013-05-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Selective binding of antimicrobial porphyrins to the heme-receptor IsdH-NEAT3 of Staphylococcus aureus Protein Sci., 22, 2013
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3W4T
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![BU of 3w4t by Molmil](/molmil-images/mine/3w4t) | Crystal structure of MATE P26A mutant | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein | 著者 | Tanaka, Y, Ishitani, R, Nureki, O. | 登録日 | 2013-01-16 | 公開日 | 2013-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | 主引用文献 | Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
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