7N14
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![BU of 7n14 by Molmil](/molmil-images/mine/7n14) | Crystal structure of 4-(1H-1,2,4-triazol-1-yl)benzoic acid-bound CYP199A4 | 分子名称: | 4-(1H-1,2,4-triazol-1-yl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2021-05-26 | 公開日 | 2022-02-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.537 Å) | 主引用文献 | To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme. Inorg.Chem., 61, 2022
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8SFF
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![BU of 8sff by Molmil](/molmil-images/mine/8sff) | CCT G beta 5 complex closed state 0 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | 著者 | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | 登録日 | 2023-04-11 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller. Mol.Cell, 83, 2023
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6ENZ
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![BU of 6enz by Molmil](/molmil-images/mine/6enz) | Crystal structure of mouse GADL1 | 分子名称: | Acidic amino acid decarboxylase GADL1, PYRIDOXAL-5'-PHOSPHATE | 著者 | Raasakka, A, Mahootchi, E, Winge, I, Luan, W, Kursula, P, Haavik, J. | 登録日 | 2017-10-07 | 公開日 | 2018-01-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the mouse acidic amino acid decarboxylase GADL1. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6EO7
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![BU of 6eo7 by Molmil](/molmil-images/mine/6eo7) | X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GA68B2 - MODIFIED HUMAN THROMBIN BINDING APTAMER, ... | 著者 | Dolot, R.M, Nawrot, B, Yang, X. | 登録日 | 2017-10-09 | 公開日 | 2017-10-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity. Nucleic Acids Res., 46, 2018
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4MF2
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![BU of 4mf2 by Molmil](/molmil-images/mine/4mf2) | Structure of human DNA polymerase beta complexed with O6MG as the template base in a 1-nucleotide gapped DNA | 分子名称: | DNA polymerase beta, SODIUM ION, synthetic downstream primer, ... | 著者 | Koag, M.C, Min, K, Monzingo, A.F, Lee, S. | 登録日 | 2013-08-27 | 公開日 | 2014-04-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136, 2014
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8SGQ
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![BU of 8sgq by Molmil](/molmil-images/mine/8sgq) | CCT G beta 5 complex intermediate state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | 著者 | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | 登録日 | 2023-04-12 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller. Mol.Cell, 83, 2023
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6EOO
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![BU of 6eoo by Molmil](/molmil-images/mine/6eoo) | DPP8 - Apo, space group 20 | 分子名称: | Dipeptidyl peptidase 8 | 著者 | Ross, B.R, Huber, R. | 登録日 | 2017-10-10 | 公開日 | 2018-02-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7NMS
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6EPL
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![BU of 6epl by Molmil](/molmil-images/mine/6epl) | Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) | 分子名称: | GLYCEROL, GTPase KRas, Son of sevenless homolog 1 | 著者 | Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Briem, H, Petersen, K, Badock, V. | 登録日 | 2017-10-12 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6EPO
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![BU of 6epo by Molmil](/molmil-images/mine/6epo) | RAS GUANINE EXCHANGE FACTOR SOS1 (REM-CDC25) IN COMPLEX WITH KRAS(G12C) AND FRAGMENT SCREENING HIT F3 | 分子名称: | 3-(4-chlorophenyl)propan-1-amine, GLYCEROL, GTPase KRas, ... | 著者 | Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V. | 登録日 | 2017-10-12 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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8SR4
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![BU of 8sr4 by Molmil](/molmil-images/mine/8sr4) | particulate methane monooxygeanse treated with potassium cyanide and copper reloaded | 分子名称: | Ammonia monooxygenase/methane monooxygenase, subunit C family protein, COPPER (II) ION, ... | 著者 | Tucci, F.J, Jodts, R.J, Rosenzweig, A.C. | 登録日 | 2023-05-05 | 公開日 | 2023-11-15 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Product analog binding identifies the copper active site of particulate methane monooxygenase. Nat Catal, 6, 2023
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6EQ9
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![BU of 6eq9 by Molmil](/molmil-images/mine/6eq9) | Crystal structure of JNK3 in complex with AMP-PCP | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Macedo, J.T, Stehle, T, Blaum, B.S. | 登録日 | 2017-10-12 | 公開日 | 2018-08-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega, 3, 2018
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6ELQ
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![BU of 6elq by Molmil](/molmil-images/mine/6elq) | Carbon Monoxide Dehydrogenase IV from Carboxydothermus hydrogenoformans | 分子名称: | Carbon Monoxide Dehydrogenase, FE(4)-NI(1)-S(5) CLUSTER with Oxygen, IRON/SULFUR CLUSTER | 著者 | Domnik, L, Goetzl, S, Jeoung, J.H, Dobbek, H. | 登録日 | 2017-09-29 | 公開日 | 2018-01-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2. Angew. Chem. Int. Ed. Engl., 56, 2017
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4LPJ
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![BU of 4lpj by Molmil](/molmil-images/mine/4lpj) | One minute iron loaded frog M ferritin | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | 登録日 | 2013-07-16 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites. Acta Crystallogr.,Sect.D, 71, 2015
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6EM9
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![BU of 6em9 by Molmil](/molmil-images/mine/6em9) | S.aureus ClpC resting state, asymmetric map | 分子名称: | ATP-dependent Clp protease ATP-binding subunit ClpC | 著者 | Carroni, M, Mogk, A, Bukau, B, Franke, K. | 登録日 | 2017-10-01 | 公開日 | 2017-12-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | 主引用文献 | Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control. Elife, 6, 2017
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4LPN
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8SWA
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![BU of 8swa by Molmil](/molmil-images/mine/8swa) | Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP | 分子名称: | (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Bruemmer, K.J, Pham, V.N, Toh, J.D.W. | 登録日 | 2023-05-18 | 公開日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism. Science, 382, 2023
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8SMD
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![BU of 8smd by Molmil](/molmil-images/mine/8smd) | Structure of Clostridium botulinum prophage Tad1 in complex with 1''-3' gcADPR | 分子名称: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, ABC transporter ATPase | 著者 | Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J. | 登録日 | 2023-04-26 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Phages overcome bacterial immunity via diverse anti-defence proteins. Nature, 625, 2024
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4MDG
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![BU of 4mdg by Molmil](/molmil-images/mine/4mdg) | Closo Carborane Carbonic Anhydrase Inhibitor | 分子名称: | 1-(sulfamoylamino)methyl-1,2-dicarba-closo-dodecaborane, Carbonic anhydrase 2, ZINC ION | 著者 | Brynda, J, Mader, P, Rezacova, P. | 登録日 | 2013-08-22 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Carborane-based carbonic anhydrase inhibitors. Angew.Chem.Int.Ed.Engl., 52, 2013
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6E32
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![BU of 6e32 by Molmil](/molmil-images/mine/6e32) | Capsid protein of PCV2 with N,O6-DISULFO-GLUCOSAMINE | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Capsid protein of PCV2 | 著者 | Khayat, R, Dhindwal, S. | 登録日 | 2018-07-13 | 公開日 | 2018-12-26 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Porcine Circovirus 2 Uses a Multitude of Weak Binding Sites To Interact with Heparan Sulfate, and the Interactions Do Not Follow the Symmetry of the Capsid. J.Virol., 93, 2019
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6E67
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![BU of 6e67 by Molmil](/molmil-images/mine/6e67) | Structure of beta2 adrenergic receptor fused to a Gs peptide | 分子名称: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera | 著者 | Liu, X, Xu, X, Hilger, D, Tiemann, J, Liu, H, Du, Y, Hirata, K, Sun, X, Guixa-Gonzalez, R, Mathiesen, J, Hildebrand, P, Kobilka, B. | 登録日 | 2018-07-24 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell, 177, 2019
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8EU9
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![BU of 8eu9 by Molmil](/molmil-images/mine/8eu9) | Class1 of the INO80-Nucleosome complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | 著者 | Wu, H, Munoz, E, Gourdet, M, Cheng, Y.F, Narlikar, G. | 登録日 | 2022-10-18 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science, 381, 2023
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8EXK
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8EEU
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![BU of 8eeu by Molmil](/molmil-images/mine/8eeu) | Venezuelan equine encephalitis virus-like particle in complex with Fab SKT05 | 分子名称: | Coat protein, Fab SKT05 heavy chain, Fab SKT05 light chain | 著者 | Tsybovsky, Y, Pletnev, S, Verardi, R, Roederer, M, Kwong, P.D. | 登録日 | 2022-09-07 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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8SR5
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![BU of 8sr5 by Molmil](/molmil-images/mine/8sr5) | |