4OCX
| Fab complex with methotrexate | 分子名称: | Fab ADD056 Heavy Chain, Fab ADD056 Light Chain, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID | 著者 | Longenecker, K.L, Judge, R.A, Gayda, S, Manoj, S, Saldana, S, Ruan, Q, Swift, K, Tetin, S. | 登録日 | 2014-01-09 | 公開日 | 2014-07-02 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Water channel in the binding site of a high affinity anti-methotrexate antibody. Biochemistry, 53, 2014
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4RQN
| Crystal structure of the native BICC1 SAM Domain R924E mutant | 分子名称: | Protein bicaudal C homolog 1, ZINC ION | 著者 | Leettola, C.N, Cascio, D, Bowie, J.U. | 登録日 | 2014-11-03 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6. Structure, 26, 2018
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4EJ8
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4RTV
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4EX1
| Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-04-29 | 公開日 | 2013-05-01 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.657 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4EY9
| Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-05-01 | 公開日 | 2013-05-01 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.471 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4EYD
| Human Insulin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. | 登録日 | 2012-05-01 | 公開日 | 2013-05-01 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.471 Å) | 主引用文献 | Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
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4RZ7
| Crystal Structure of PVX_084705 with bound PCI32765 | 分子名称: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, UNKNOWN ATOM OR ION, cGMP-dependent protein kinase, ... | 著者 | Jiang, D.Q, Tempel, W, Loppnau, P, Graslund, S, He, H, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Amani, M, Structural Genomics Consortium (SGC) | 登録日 | 2014-12-18 | 公開日 | 2015-01-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.351 Å) | 主引用文献 | Crystal Structure of PVX_084705 with bound PCI32765 To be Published
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4ENX
| Crystal Structure of Pim-1 Kinase in complex with inhibitor (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-nitrobenzylidene)thiazolidin-4-one | 分子名称: | (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-nitrobenzylidene)-1,3-thiazolidin-4-one, PHOSPHATE ION, Serine/threonine-protein kinase pim-1 | 著者 | Parker, L.J, Handa, N, Yokoyama, S. | 登録日 | 2012-04-13 | 公開日 | 2012-08-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Acta Crystallogr.,Sect.F, 68, 2012
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4EJE
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4EK1
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4RSQ
| 2.9A resolution structure of SRPN2 (K198C/E359C) from Anopheles gambiae | 分子名称: | Serpin 2 | 著者 | Lovell, S, Battaile, K.P, Zhang, X, Meekins, D.A, An, C, Michel, K. | 登録日 | 2014-11-10 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae. J.Biol.Chem., 290, 2015
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4NFF
| Human kallikrein-related peptidase 2 in complex with PPACK | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Kallikrein-2 | 著者 | Skala, W, Brandstetter, H, Magdolen, V, Goettig, P. | 登録日 | 2013-10-31 | 公開日 | 2014-10-29 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity J.Biol.Chem., 289, 2014
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4PRN
| Crystal structure of a HLA-B*35:01-HPVG-A4 | 分子名称: | ACETATE ION, Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, ... | 著者 | Yu Chih, L, Rossjohn, J, Gras, S. | 登録日 | 2014-03-06 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism. J.Biol.Chem., 289, 2014
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3WIG
| Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP | 分子名称: | CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Lukacs, C.M, Janson, C, Schuck, V. | 登録日 | 2013-09-12 | 公開日 | 2014-06-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors Cancer Cell, 25, 2014
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4NKP
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4PNY
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3WBB
| Crystal Structures of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum | 分子名称: | Diaminopimelate dehydrogenase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M. | 登録日 | 2013-05-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum. Chembiochem, 15, 2014
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3WXP
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4PPY
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4PRD
| Crystal structure of a HLA-B*35:08-HPVG-D5 | 分子名称: | ACETATE ION, Beta-2-microglobulin, Epstein-Barr nuclear antigen 1, ... | 著者 | Yu Chih, L, Rossjohn, J, Gras, S. | 登録日 | 2014-03-05 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism. J.Biol.Chem., 289, 2014
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3WT3
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4PRX
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4PSG
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3WHA
| Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor | 分子名称: | 4-{[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl]sulfanyl}butanamide, GLYCEROL, Heat shock protein HSP 90-alpha, ... | 著者 | Fukami, T.A, Ono, N. | 登録日 | 2013-08-23 | 公開日 | 2014-01-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors Bioorg.Med.Chem., 22, 2014
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