4ENX

Crystal Structure of Pim-1 Kinase in complex with inhibitor (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-nitrobenzylidene)thiazolidin-4-one

Summary for 4ENX

Entry DOI	10.2210/pdb4enx/pdb
Related	3UIX 3UMW 3UMX 4ENY
Descriptor	Serine/threonine-protein kinase pim-1, PHOSPHATE ION, (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-nitrobenzylidene)-1,3-thiazolidin-4-one, ... (4 entities in total)
Functional Keywords	pim-1 kinase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34658.48
Authors	Parker, L.J.,Handa, N.,Yokoyama, S. (deposition date: 2012-04-13, release date: 2012-08-08, Last modification date: 2023-11-08)
Primary citation	Parker, L.J.,Watanabe, H.,Tsuganezawa, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yuki, H.,Honma, T.,Ogawa, N.,Nagano, T.,Yokoyama, S.,Tanaka, A. Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Acta Crystallogr.,Sect.F, 68:860-866, 2012 Cited by PubMed: 22869110 DOI: 10.1107/S1744309112027108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation