PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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8CSQ	Human mitochondrial small subunit assembly intermediate (State B) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
8CSU	Human mitochondrial small subunit assembly intermediate (State C*) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
8CST	Human mitochondrial small subunit assembly intermediate (State E) 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Harper, N.J, Burnside, C, Klinge, S. 登録日 2022-05-13 公開日 2022-12-14 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
8D8K	Yeast mitochondrial small subunit assembly intermediate (State 2) 分子名称: 15S ribosomal RNA, 37S ribosomal protein MRP1, mitochondrial, ... 著者 Burnside, C, Harper, N.J, Klinge, S. 登録日 2022-06-08 公開日 2022-12-21 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
8D8J	Yeast mitochondrial small subunit assembly intermediate (State 1) 分子名称: 15S ribosomal RNA, 37S ribosomal protein MRP13, mitochondrial, ... 著者 Burnside, C, Harper, N, Klinge, S. 登録日 2022-06-08 公開日 2022-12-21 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Principles of mitoribosomal small subunit assembly in eukaryotes. Nature, 614, 2023
6WVX	Crystal structure of the first bromodomain of human BRD4 with benzodiazepine inhibitor 分子名称: 6'-(4-chlorophenyl)-1'-methyl-8'-(1-methyl-1H-pyrazol-4-yl)spiro[cyclopropane-1,4'-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine], Bromodomain-containing protein 4 著者 Eron, S.J. 登録日 2020-05-07 公開日 2021-09-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design. Acs Chem.Biol., 16, 2021
1H7V	Rubredoxin from Guillardia Theta 分子名称: RUBREDOXIN, ZINC ION 著者 Schweimer, K, Hoffmann, S, Wastl, J, Maier, U.G, Roesch, P, Sticht, H. 登録日 2001-01-16 公開日 2002-01-29 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of a zinc substituted eukaryotic rubredoxin from the cryptomonad alga Guillardia theta. Protein Sci., 9, 2000
2HDJ	Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H) 分子名称: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C2, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Faucher, F, Pereira de Jesus-Tran, K, Cantin, L, Luu-the, V, Labrie, F, Breton, R. 登録日 2006-06-20 公開日 2006-12-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme. J.Mol.Biol., 364, 2006
7PXA	Open-gate mycobacterium 20S CP proteasome in complex MPA - global 3D refinement 分子名称: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta 著者 Jomaa, A, Kavalchuk, M, Weber-Ban, E. 登録日 2021-10-08 公開日 2022-01-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat Commun, 13, 2022
5LCL	STRUCTURE OF the RAD14 DNA-binding domain IN COMPLEX WITH C8-aminofluorene- GUANINE CONTAINING DNA 分子名称: DNA (5'-D(*GP*TP*GP*AP*TP*GP*AP*CP*GP*TP*AP*GP*AP*G)-3'), DNA repair protein RAD14, GCTCTAC(8AF)TCATCA, ... 著者 Schneider, S, Carell, T, Ebert, C, Simon, N. 登録日 2016-06-22 公開日 2017-05-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Insights into the Recognition of N(2) -Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14. Chembiochem, 18, 2017
5LCM	STRUCTURE OF the RAD14 DNA-binding domain IN COMPLEX WITH N2-acetylaminonaphtyl- GUANINE CONTAINING DNA 分子名称: DNA (5'-D(*GP*CP*TP*CP*TP*AP*CP*(AAN)P*TP*CP*AP*TP*CP*A)-3'), DNA (5'-D(*GP*TP*GP*AP*TP*GP*AP*CP*GP*TP*AP*GP*AP*G)-3'), DNA repair protein RAD14, ... 著者 Schneider, S, Ebert, C, Simon, N, Carell, T. 登録日 2016-06-22 公開日 2017-05-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Insights into the Recognition of N(2) -Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14. Chembiochem, 18, 2017
6OQA	Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product 分子名称: (3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... 著者 Lee, S.-J, Shigdel, U.K, Townson, S.A, Verdine, G.L. 登録日 2019-04-26 公開日 2020-04-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc.Natl.Acad.Sci.USA, 117, 2020
8F5P	Structure of Leishmania tarentolae IFT-A (state 2) 分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 122B, putative, ... 著者 Zhou, H, Brown, A. 登録日 2022-11-14 公開日 2022-12-21 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Mechanism of IFT-A polymerization into trains for ciliary transport. Cell, 185, 2022
8F5O	Structure of Leishmania tarentolae IFT-A (state 1) 分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 122B, putative, ... 著者 Zhou, H, Brown, A. 登録日 2022-11-14 公開日 2022-12-21 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Mechanism of IFT-A polymerization into trains for ciliary transport. Cell, 185, 2022
3RGD	Iron loaded frog M ferritin. Short soaking time 分子名称: FE (III) ION, Ferritin, middle subunit 著者 Bertini, I, Lalli, D, Mangani, S, Pozzi, C, Rosa, C, Theil, E.C, Turano, P. 登録日 2011-04-08 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structural insights into the ferroxidase site of ferritins from higher eukaryotes. J.Am.Chem.Soc., 134, 2012
2IY5	PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS complexed with tRNA and a phenylalanyl-adenylate analog 分子名称: ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ... 著者 Moor, N, Kotik-Kogan, O, Tworowski, D, Sukhanova, M, Safro, M. 登録日 2006-07-12 公開日 2006-09-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end. Biochemistry, 45, 2006
3OMX	Crystal structure of Ssu72 with vanadate complex 分子名称: CG14216, VANADATE ION 著者 Zhang, Y, Zhang, M, Zhang, Y. 登録日 2010-08-27 公開日 2011-01-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3366 Å) 主引用文献 Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem.J., 434, 2011
1Y6W	Trapped intermediate of calmodulin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Calmodulin, ... 著者 Grabarek, Z. 登録日 2004-12-07 公開日 2005-03-01 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of a Trapped Intermediate of Calmodulin: Calcium Regulation of EF-hand Proteins from a New Perspective. J.Mol.Biol., 346, 2005
2JU4	NMR structure of the gamma subunit of cGMP phosphodiesterase 分子名称: (3'R)-1'-oxyl-2',2',5',5'-tetramethyl-1,3'-bipyrrolidine-2,5-dione, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma 著者 Song, J, Guo, L.W, Ruoho, A.E, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) 登録日 2007-08-14 公開日 2007-10-16 最終更新日 2020-02-19 実験手法 SOLUTION NMR 主引用文献 Intrinsically disordered gamma-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure. Proc.Natl.Acad.Sci.USA, 105, 2008
2PI6	Crystal structure of the sheep signalling glycoprotein (SPS-40) complex with 2-methyl-2-4-pentanediol at 1.65A resolution reveals specific binding characteristics of SPS-40 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Chitinase-3-like protein 1, ETHANOL, ... 著者 Sharma, P, Singh, N, Sharma, S, Kaur, P, Betzel, C, Singh, T.P. 登録日 2007-04-13 公開日 2007-05-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution. Acta Crystallogr.,Sect.D, 65, 2009
4R4J	Crystal structure of complex sp_ASADH with 3-carboxypropyl-phthalic acid and Nicotinamide Adenine dinucleotide phosphate 分子名称: 1,2-ETHANEDIOL, 3-(3-carboxypropyl)benzene-1,2-dicarboxylic acid, Aspartate-semialdehyde dehydrogenase, ... 著者 Pavlovsky, A.G, Thangavelu, B, Bhansali, P, Viola, R.E. 登録日 2014-08-19 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70, 2014
4R51	Crystal complex structure of sp-Aspartate-Semialdehyde-Dehydrogenase with Nicotinamide Adenine dinucleotide phosphate and phthalic acid 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ... 著者 Pavlovsky, A.G, Viola, R.E. 登録日 2014-08-20 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70, 2014
4R41	Complex Crystal structure of 4-nitro-2-phosphono-benzoic acid with sp-Aspartate-Semialdehyde Dehydrogenase and Nicotinamide-dinucleotide 分子名称: 1,2-ETHANEDIOL, 4-nitro-2-phosphonobenzoic acid, ACETATE ION, ... 著者 Pavlovsky, A.G, Viola, R.E. 登録日 2014-08-18 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70, 2014
6MO9	N-terminal bromodomain of human BRD2 in complex with N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)quinoline-5-sulfonamide inhibitor 分子名称: Bromodomain-containing protein 2, N-cyclopentyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-5-sulfonamide 著者 Lansdon, E.B, Newby, Z.E.R. 登録日 2018-10-04 公開日 2019-01-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg. Med. Chem., 27, 2019
6MO8	N-terminal bromodomain of human BRD2 in complex with 4,4'-(quinoline-5,7-diyl)bis(3,5-dimethylisoxazole) inhibitor 分子名称: 5,7-bis(3,5-dimethyl-1,2-oxazol-4-yl)quinoline, Bromodomain-containing protein 2, SULFATE ION 著者 Lansdon, E.B, Newby, Z.E.R. 登録日 2018-10-04 公開日 2019-01-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg. Med. Chem., 27, 2019

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