8SEM
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7JUP
| Structure of human TRPA1 in complex with antagonist compound 21 | 分子名称: | 1-({3-[(3R,5R)-5-(4-fluorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl}methyl)-7-methyl-1,7-dihydro-6H-purin-6-one, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L. | 登録日 | 2020-08-20 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy. J.Med.Chem., 64, 2021
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7D7E
| Structure of PKD1L3-CTD/PKD2L1 in apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | 著者 | Su, Q, Chen, M, Li, B, Wang, Y, Jing, D, Zhan, X, Yu, Y, Shi, Y. | 登録日 | 2020-10-03 | 公開日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021
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7D7F
| Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | 著者 | Su, Q, Shi, Y.G. | 登録日 | 2020-10-03 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021
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2RFA
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8FOA
| Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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8FOB
| Cryo-EM structure of human TRPV6 in the open state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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6O6A
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state | 分子名称: | CHOLESTEROL HEMISUCCINATE, SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-05 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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6O6R
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, AMTB-bound state | 分子名称: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, CHOLESTEROL HEMISUCCINATE, N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-[(thiophen-2-yl)methyl]benzamide, ... | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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6O72
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state | 分子名称: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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6O77
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state | 分子名称: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | 著者 | Diver, M.M, Cheng, Y, Julius, D. | 登録日 | 2019-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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7LPE
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPA
| Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LP9
| Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPB
| Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPD
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPC
| Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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5AN8
| Cryo-electron microscopy structure of rabbit TRPV2 ion channel | 分子名称: | TRPV2 | 著者 | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | 登録日 | 2015-09-04 | 公開日 | 2015-12-23 | 最終更新日 | 2019-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-Electron Microscopy of the Trpv2 Ion Channel Nat.Struct.Mol.Biol., 23, 2016
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5VKQ
| Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, No mechanoreceptor potential C isoform L | 著者 | Jin, P, Bulkley, D, Guo, Y, Zhang, W, Guo, Z, Huynh, W, Wu, S, Meltzer, S, Chen, T, Jan, L.Y, Jan, Y.-N, Cheng, Y. | 登録日 | 2017-04-22 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature, 547, 2017
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6G1K
| Electron cryo-microscopy structure of the canonical TRPC4 ion channel | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily c member 4a | 著者 | Vinayagam, D, Mager, T, Apelbaum, A, Bothe, A, Merino, F, Hofnagel, O, Gatsogiannis, C, Raunser, S. | 登録日 | 2018-03-21 | 公開日 | 2018-05-02 | 最終更新日 | 2018-08-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Electron cryo-microscopy structure of the canonical TRPC4 ion channel. Elife, 7, 2018
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8K3S
| Structure of PKD2-F604P complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | 登録日 | 2023-07-16 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands. Proc.Natl.Acad.Sci.USA, 121, 2024
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8HK7
| Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, CALCIUM ION, ... | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | 登録日 | 2022-11-25 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands. Proc.Natl.Acad.Sci.USA, 121, 2024
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2ETB
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2ETA
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2ETC
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