PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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3CJ0	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 分子名称: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, RNA-directed RNA polymerase 著者 Kissinger, c. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
6Z8K	La Crosse virus polymerase at elongation mimicking stage 分子名称: La Crosse virus 3' vRNA (1-16), La Crosse virus 5' vRNA (9-16), La Crosse virus 5' vRNA 1-10, ... 著者 Arragain, B, Effantin, G, Schoehn, G, Cusack, S, Malet, H. 登録日 2020-06-02 公開日 2020-07-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat Commun, 11, 2020
6Z6G	Cryo-EM structure of La Crosse virus polymerase at pre-initiation stage 分子名称: 3'vRNA 1-16, 5'vRNA 1-10, 5'vRNA 9-16, ... 著者 Arragain, B, Effantin, G, Gerlach, P, Reguera, J, Schoehn, G, Cusack, S, Malet, H. 登録日 2020-05-28 公開日 2020-07-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat Commun, 11, 2020
4NLO	Poliovirus Polymerase - C290I Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
3CJ3	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: 4-bromo-2-{[(2R)-2-(2-chlorobenzyl)pyrrolidin-1-yl]carbonyl}aniline, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Kissinger, c. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CJ4	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: 4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Antonysamy, s.s. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3CIZ	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments 分子名称: 2-amino-5-bromobenzoic acid, RNA-directed RNA polymerase, ZINC ION 著者 Hendle, j. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
4NLP	Poliovirus Polymerase - C290V Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
4NLS	Poliovirus Polymerase - S288A Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
8ASD	Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION] 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2022-08-19 公開日 2023-01-18 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
7KRN	Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2020-11-20 公開日 2021-04-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
7KRP	Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement) 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHAPSO, MAGNESIUM ION, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2020-11-20 公開日 2021-04-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
7KRO	Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... 著者 Chen, J, Malone, B, Campbell, E.A, Darst, S.A. 登録日 2020-11-20 公開日 2021-04-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
3A1G	High-Resolution Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus 分子名称: Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Sugiyama, K, Park, S.-Y, Obayashi, E. 登録日 2009-04-02 公開日 2009-06-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase Embo J., 28, 2009
7UO7	SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO9	SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOB	SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOE	SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO4	SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7L1F	SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate 分子名称: Non-structural protein 7, Non-structural protein 8, RNA (5'-R(P*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*G)-3'), ... 著者 Bravo, J.P.K, Taylor, D.W. 登録日 2020-12-14 公開日 2021-02-10 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Mol.Cell, 81, 2021
2GIR	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor 分子名称: 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
2R7U	Crystal Structure of Rotavirus SA11 VP1/RNA (AAAAGCC) Complex 分子名称: RNA (5'-R(*AP*A*AP*AP*GP*CP*C)-3'), RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-10 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
2R7X	Crystal Structure of Rotavirus SA11 VP1/RNA (UGUGACC)/GTP complex 分子名称: GUANOSINE-5'-TRIPHOSPHATE, RNA (5'-R(*UP*GP*UP*GP*AP*CP*C)-3'), RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-10 公開日 2008-07-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
2R7W	Crystal Structure of Rotavirus SA11 VP1/RNA (UGUGACC)/mRNA 5'-CAP (m7GpppG) complex 分子名称: GUANOSINE-5'-TRIPHOSPHATE, RNA (5'-R(*UP*GP*UP*GP*AP*CP*C)-3'), RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-10 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
1NHV	Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor 分子名称: (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID, HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE 著者 Wang, M, Ng, K.K.S, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bedard, J, Morin, N, Nguyen-Ba, N, Alaoui-Ismaili, M.H, Bethell, R.C, James, M.N.G. 登録日 2002-12-19 公開日 2003-03-18 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition J.Biol.Chem., 278, 2003

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