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6GLE
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BU of 6gle by Molmil
Crystal structure of hMTH1 in complex with TH scaffold 1 in the presence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.402 Å)
主引用文献hMTH1 in complex with TH scaffold 1
To Be Published
6GLK
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BU of 6glk by Molmil
Crystal structure of hMTH1 N33A in the presence of acetate
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献in progress
To Be Published
6GLR
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BU of 6glr by Molmil
Crystal structure of hMTH1 N33G in complex with TH scaffold 1 in the presence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献hMTH1 N33G in complex with TH scaffold 1
To Be Published
6GLG
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BU of 6glg by Molmil
Crystal structure of hMTH1 F27A in complex with LW14 in the presence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.313 Å)
主引用文献hMTH1 F27A in complex with LW14
To Be Published
6GLM
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BU of 6glm by Molmil
Crystal structure of hMTH1 N33A in complex with LW14 in the absence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献hMTH1 N33A in complex with LW14
To Be Published
6GLS
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BU of 6gls by Molmil
Crystal structure of hMTH1 N33G in complex with TH scaffold 1 in the absence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献hMTH1 N33G in complex with TH scaffold 1.
To Be Published
6GLH
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BU of 6glh by Molmil
Crystal structure of hMTH1 F27A in complex with LW14 in the absence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.201 Å)
主引用文献hMTH1 F27A in complex with LW14
To Be Published
6GLJ
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BU of 6glj by Molmil
Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the absence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.301 Å)
主引用文献hMTH1 F27A in complex with TH scaffold 1.
To Be Published
6GLO
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BU of 6glo by Molmil
Crystal structure of hMTH1 N33G in the presence of acetate
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献hMTH1 N33G
To Be Published
6GLP
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BU of 6glp by Molmil
Crystal structure of hMTH1 N33G in complex with LW14 in the presence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献hMTH1 N33G in complex with LW14
To Be Published
6GRU
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BU of 6gru by Molmil
Crystal structure of human NUDT5
分子名称: 1,2-ETHANEDIOL, ADP-sugar pyrophosphatase, CHLORIDE ION, ...
著者Dubianok, Y, Collins, P, Krojer, T, Fairhead, M, MacLean, E, Diaz Saez, L, Strain-Damerell, C, Elkins, J, Burgess-Brown, N, Bountra, C, Arrowsmith, C.H, Edwards, A, Huber, K, von Delft, F, Structural Genomics Consortium (SGC)
登録日2018-06-12
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal structure of human NUDT5
To Be Published
6IMZ
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BU of 6imz by Molmil
Crystal structure of MTH1 in complex with 18-Crown-6
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ...
著者Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
登録日2018-10-24
公開日2019-10-30
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6ILI
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BU of 6ili by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
著者Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
登録日2018-10-18
公開日2018-11-07
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
6IJY
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BU of 6ijy by Molmil
Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 8-oxo-dGTP determined using a crystal obtained under microgravity
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
著者Nakamura, T, Yamagata, Y.
登録日2018-10-12
公開日2019-02-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.04 Å)
主引用文献X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity.
Int. J. Microgravity Sci. Appl., 36, 2019
6GLI
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BU of 6gli by Molmil
Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the presence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献hMTH1 F27A in complex with TH scaffold 1
To Be Published
6GLN
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BU of 6gln by Molmil
Crystal structure of hMTH1 N33A in complex with TH scaffold 1 in the absence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献hMTH1 N33A in complex with TH scaffold 1
To Be Published
6GLV
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BU of 6glv by Molmil
Crystal structure of hMTH1 D120N in complex with TH scaffold 1 in the absence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献hMTH1 D120N in complex with TH scaffold 1
To Be Published
6GLT
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BU of 6glt by Molmil
Crystal structure of hMTH1 D120N in the presence of acetate
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, DIMETHYL SULFOXIDE
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.596 Å)
主引用文献in progress
To Be Published
6GLQ
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BU of 6glq by Molmil
Crystal structure of hMTH1 N33G in complex with LW14 in the absence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献hMTH1 N33G in complex with LW14.
To Be Published
7B67
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BU of 7b67 by Molmil
Structure of NUDT15 V18_V19insGV Mutant in complex with TH7755
分子名称: (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, MAGNESIUM ION, Nucleotide triphosphate diphosphatase NUDT15, ...
著者Rehling, D, Stenmark, P.
登録日2020-12-07
公開日2021-03-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J.Biol.Chem., 296, 2021
7B65
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BU of 7b65 by Molmil
Structure of NUDT15 R139C Mutant in complex with TH7755
分子名称: (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, Nucleotide triphosphate diphosphatase NUDT15
著者Rehling, D, Stenmark, P.
登録日2020-12-07
公開日2021-03-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J.Biol.Chem., 296, 2021
7B63
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BU of 7b63 by Molmil
Structure of NUDT15 in complex with TH7755
分子名称: (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, MAGNESIUM ION, Probable 8-oxo-dGTP diphosphatase NUDT15
著者Rehling, D, Stenmark, P.
登録日2020-12-07
公開日2021-03-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J.Biol.Chem., 296, 2021
7B64
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BU of 7b64 by Molmil
Structure of NUDT15 V18I Mutant in complex with TH7755
分子名称: (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, Nucleotide triphosphate diphosphatase NUDT15
著者Rehling, D, Stenmark, P.
登録日2020-12-07
公開日2021-03-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J.Biol.Chem., 296, 2021
7B66
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BU of 7b66 by Molmil
Structure of NUDT15 R139H Mutant in complex with TH7755
分子名称: (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, Nucleotide triphosphate diphosphatase NUDT15
著者Rehling, D, Stenmark, P.
登録日2020-12-07
公開日2021-03-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J.Biol.Chem., 296, 2021
7AUM
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BU of 7aum by Molmil
Yeast Diphosphoinositol Polyphosphate Phosphohydrolase DDP1 in complex with 5-PCF2Am-InsP5
分子名称: (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid, Diphosphoinositol polyphosphate phosphohydrolase DDP1
著者Marquez-Monino, M.A, Gonzalez, B.
登録日2020-11-03
公開日2021-05-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping.
Sci Adv, 7, 2021

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件を2024-10-16に公開中

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