6ILI
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5
Summary for 6ILI
Entry DOI | 10.2210/pdb6ili/pdb |
Related | 5GHM |
Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE (3 entities in total) |
Functional Keywords | alpha-beta-alpha sandwich, hydrolase, dna damage, dna repair, dna replication |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 37131.57 |
Authors | Nakamura, T.,Waz, S.,Hirata, K.,Nakabeppu, Y.,Yamagata, Y. (deposition date: 2018-10-18, release date: 2018-11-07, Last modification date: 2024-03-27) |
Primary citation | Waz, S.,Nakamura, T.,Hirata, K.,Koga-Ogawa, Y.,Chirifu, M.,Arimori, T.,Tamada, T.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y. Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292:2785-2794, 2017 Cited by PubMed: 28035004DOI: 10.1074/jbc.M116.749713 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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