6ILI

Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	7,8-dihydro-8-oxoguanine triphosphatase	polymer	156	18042.6	2	UniProt (P36639) Pfam (PF00293)	Homo sapiens (Human)	2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1
2	C, D (A, B)	8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (8DG)
3	E, F (A, B)	water	water		18.0	324	Chemie (HOH)

Sequence modifications

A, B: 1 - 156 (UniProt: P36639)

PDB	External Database	Details
Lys 2	Gly 43	engineered mutation
Asn 120	Asp 161	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36085.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1046.4
All*	Total formula weight	37131.6

*Water molecules are not included.