6ILI
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 156 | 18042.6 | 2 | UniProt (P36639) Pfam (PF00293) In PDB | Homo sapiens (Human) | 2-hydroxy-dATP diphosphatase,8-oxo-dGTPase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
2 | A, B | 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (8DG) | |||
3 | water | water | 18.0 | 324 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
PDB | External Database | Details |
---|---|---|
Lys 2 | Gly 43 | engineered mutation |
Asn 120 | Asp 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 36085.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1046.4 | |
All* | Total formula weight | 37131.6 |