7B65
Structure of NUDT15 R139C Mutant in complex with TH7755
Summary for 7B65
| Entry DOI | 10.2210/pdb7b65/pdb |
| Descriptor | Nucleotide triphosphate diphosphatase NUDT15, (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one (3 entities in total) |
| Functional Keywords | inhibitor, complex, nucleoside triphosphate pyrophosphohydrolase, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 38070.90 |
| Authors | Rehling, D.,Stenmark, P. (deposition date: 2020-12-07, release date: 2021-03-24, Last modification date: 2024-01-31) |
| Primary citation | Rehling, D.,Zhang, S.M.,Jemth, A.S.,Koolmeister, T.,Throup, A.,Wallner, O.,Scaletti, E.,Moriyama, T.,Nishii, R.,Davies, J.,Desroses, M.,Rudd, S.G.,Scobie, M.,Homan, E.,Berglund, U.W.,Yang, J.J.,Helleday, T.,Stenmark, P. Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. J.Biol.Chem., 296:100568-100568, 2021 Cited by PubMed: 33753169DOI: 10.1016/j.jbc.2021.100568 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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