7B65
Structure of NUDT15 R139C Mutant in complex with TH7755
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nucleotide triphosphate diphosphatase NUDT15 | polymer | 164 | 18581.0 | 2 | UniProt (Q9NV35) Pfam (PF00293) | Homo sapiens (Human) | MutT homolog 2,MTH2,Nucleoside diphosphate-linked moiety X motif 15,Nudix motif 15,Nucleoside diphosphate-linked to another moiety X hydrolase 15,Nudix hydrolase 15 |
| 2 | C, D (A, B) | (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one | non-polymer | 454.5 | 2 | Chemie (SYW) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 164 (UniProt: Q9NV35)
| PDB | External Database | Details |
|---|---|---|
| Cys 139 | Arg 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37161.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 909.0 | |
| All* | Total formula weight | 38070.9 |
