PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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5FUZ	Extending the half-life of a Fab fragment through generation of a humanised anti-Human Serum Albumin (HSA) Fv domain: an investigation into the correlation between affinity and serum half-life 分子名称: 645 FAB, HEAVY CHAIN, LIGHT CHAIN 著者 Adams, R, Ceska, T. 登録日 2016-02-01 公開日 2016-06-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life. Mabs, 8, 2016
5TM7	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC compound, 7-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenoxy)heptanoic acid 分子名称: 7-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}heptanoic acid, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
6GLJ	Crystal structure of hMTH1 F27A in complex with TH scaffold 1 in the absence of acetate 分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. 登録日 2018-05-23 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.301 Å) 主引用文献 hMTH1 F27A in complex with TH scaffold 1. To Be Published
6GLO	Crystal structure of hMTH1 N33G in the presence of acetate 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. 登録日 2018-05-23 公開日 2019-02-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 hMTH1 N33G To Be Published
5TLG	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with (E)-4,4''-dihydroxy-3'-((hydroxyiminio)methyl)-[1,1':2',1''-terphenyl]-4'-olate 分子名称: 2~3~-[(E)-(hydroxyimino)methyl][1~1~,2~1~:2~2~,3~1~-terphenyl]-1~4~,2~4~,3~4~-triol, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-11 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.228 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5TM8	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC compound, 7-(4-((1R,4S,6R)-6-((4-bromophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenoxy)heptanoic acid 分子名称: 7-{4-[(1S,4S,6R)-6-[(4-bromophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenoxy}heptanoic acid, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
6GLH	Crystal structure of hMTH1 F27A in complex with LW14 in the absence of acetate 分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. 登録日 2018-05-23 公開日 2019-02-20 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.201 Å) 主引用文献 hMTH1 F27A in complex with LW14 To Be Published
6GLP	Crystal structure of hMTH1 N33G in complex with LW14 in the presence of acetate 分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... 著者 Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A. 登録日 2018-05-23 公開日 2019-02-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 hMTH1 N33G in complex with LW14 To Be Published
5THT	Crystal Structure of G303A HDAC8 in complex with M344 分子名称: 1,2-ETHANEDIOL, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2016-09-30 公開日 2016-12-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.407 Å) 主引用文献 Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8. Biochemistry, 55, 2016
5TM9	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC Analog, (E)-3-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)acrylic acid 分子名称: 3-{4-[(1S,4S,6R)-6-[(3-chlorophenoxy)sulfonyl]-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl]phenyl}prop-2-enoic acid, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
1M4M	Mouse Survivin 分子名称: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5, ZINC ION 著者 Muchmore, S.W, Chen, J, Jakob, C, Zakula, D, Matayoshi, E.D, Wu, W, Zhang, H, Li, F, Ng, S.C, Altieri, D.C. 登録日 2002-07-03 公開日 2002-09-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN MOL.CELL, 6, 2000
5TM1	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 2,5-bis(2-fluoro-4-hydroxyphenyl)thiophene 1-oxide 分子名称: 2,5-bis(2-fluoro-4-hydroxyphenyl)-1H-1lambda~4~-thiophen-1-one, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Wright, N.J, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.231 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5VNY	Crystal structure of DM14-3 domain of Lgd 分子名称: Lethal (2) giant discs 1, isoform B 著者 McMillan, B.J, Blacklow, S.C. 登録日 2017-05-01 公開日 2017-06-14 実験手法 X-RAY DIFFRACTION (1.101 Å) 主引用文献 Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell Rep, 19, 2017
6J08	Crystal structure of human MAJIN and TERB2 分子名称: Membrane-anchored junction protein, Telomere repeats-binding bouquet formation protein 2 著者 Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M. 登録日 2018-12-21 公開日 2019-02-27 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun, 10, 2019
6JPQ	CryoEM structure of Abo1 hexamer - ADP complex 分子名称: Uncharacterized AAA domain-containing protein C31G5.19 著者 Cho, C, Jang, J, Song, J.J. 登録日 2019-03-27 公開日 2020-08-19 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.44 Å) 主引用文献 Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone. Nat Commun, 10, 2019
1MK2	SMAD3 SBD complex 分子名称: ACETIC ACID, Madh-interacting protein, SMAD 3 著者 Qin, B.Y, Lam, S.S, Correia, J.J, Lin, K. 登録日 2002-08-28 公開日 2002-10-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control Genes Dev., 16, 2002
5V5P	Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha 分子名称: Importin subunit alpha-1, Nucleoprotein 著者 Sankhala, R.S, Lokareddy, R.K, Cingolani, G. 登録日 2017-03-14 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
4MMK	Q8A Hfq from Pseudomonas aeruginosa 分子名称: POTASSIUM ION, Protein hfq, SODIUM ION, ... 著者 Murina, V.N, Filimonov, V.V, Melnik, B.S, Uhlein, M, Mueller, U, Weiss, M, Nikulin, A.D. 登録日 2013-09-09 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.156 Å) 主引用文献 Effect of conserved intersubunit amino Acid substitutions on hfq protein structure and stability. Biochemistry Mosc., 79, 2014
6JPU	CryoEM structure of Abo1 hexamer - apo complex 分子名称: Uncharacterized AAA domain-containing protein C31G5.19 著者 Cho, C, Jang, J, Song, J.J. 登録日 2019-03-28 公開日 2019-12-25 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.27 Å) 主引用文献 Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone. Nat Commun, 10, 2019
1C1C	CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123 分子名称: 6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione, HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN) 著者 Hopkins, A.L, Ren, J, Tanaka, H, Baba, M, Okamato, M, Stuart, D.I, Stammers, D.K. 登録日 1999-07-21 公開日 2000-07-21 最終更新日 2014-11-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J.Med.Chem., 42, 1999
6JQY	Crystal structure of N-terminal domain of VapB46 antitoxin from Mycobacterium tuberculosis 分子名称: ACETATE ION, Antitoxin VapB46 著者 Roy, M, Singh, B.K, Bhattacharyya, S, Das, A.K. 登録日 2019-04-02 公開日 2020-04-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.643 Å) 主引用文献 Crystal structure of N-terminal domain of VapB46 antitoxin from Mycobacterium tuberculosis To Be Published
8XM7	Cryo-EM structure of the RhoG/DOCK5/ELMO1/Rac1 complex: RhoG/DOCK5/ELMO1 focused map 分子名称: Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. 登録日 2023-12-27 公開日 2024-06-26 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.91 Å) 主引用文献 RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., 300, 2024
5HHL	Reverse transcriptase domain of group II intron maturase from Eubacterium rectale in P21 space group 分子名称: POTASSIUM ION, Retron-type reverse transcriptase 著者 Zhao, C, Pyle, A.M. 登録日 2016-01-11 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat.Struct.Mol.Biol., 23, 2016
5I98	Structure of apo FKBP12(P104G) from C. albicans 分子名称: FK506-binding protein 1 著者 Schumacher, M.A. 登録日 2016-02-19 公開日 2016-09-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
5I76	Crystal structure of FM318, a recombinant Fab adopted from cetuximab 分子名称: FM318_heavy_cahin, FM318_light_chain 著者 Sim, D.W, Kim, J.H, Seok, S.H, Seo, M.D, Kim, Y.P, Won, H.S. 登録日 2016-02-16 公開日 2016-12-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.922 Å) 主引用文献 Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor. Appl.Microbiol.Biotechnol., 100, 2016

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