5THT

Crystal Structure of G303A HDAC8 in complex with M344

Summary for 5THT

Entry DOI	10.2210/pdb5tht/pdb
Related	5THS 5THU 5THV
Descriptor	Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ... (6 entities in total)
Functional Keywords	zinc histone deacetylase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	176463.89
Authors	Porter, N.J.,Christianson, D.W. (deposition date: 2016-09-30, release date: 2016-12-21, Last modification date: 2023-10-04)
Primary citation	Porter, N.J.,Christianson, N.H.,Decroos, C.,Christianson, D.W. Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8. Biochemistry, 55:6718-6729, 2016 Cited by PubMed: 27933794 DOI: 10.1021/acs.biochem.6b01014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.407 Å)

Structure validation