9QZ2
 
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9QZ1
 | | MINPP1 from Bacteroides thetaiotaomicron E325N mutant complex with myo-inositol(1,2,4,5,6)pentaphosphate | | 分子名称: | (1R,2R,3R,4S,5R,6R)-6-hydroxycyclohexane-1,2,3,4,5-pentayl pentakis[dihydrogen (phosphate)], multiple inositol polyphosphate histidine phosphatase 1 | | 著者 | Li, A.W.H, Shang, X.Y, Hemmings, A.M. | | 登録日 | 2025-04-22 | | 公開日 | 2025-06-11 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | A Structural Basis for the Stereospecificity of Multiple Inositol Polyphosphate Phosphatases
To Be Published
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9QZ3
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9QYY
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9QYZ
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9QYX
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9QZ0
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9QYV
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9QYW
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9NFR
 | | Crystal structure of CRBN-DDB1 and MRT-23227 in complex with VAV1 | | 分子名称: | (3R)-3-{2-chloro-4'-[(1-methyl-1H-pyrazol-3-yl)methoxy][1,1'-biphenyl]-3-yl}piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Trenh, P, Bunker, R.D, Lucas, X, Gainza, P, Tsai, J.H.C. | | 登録日 | 2025-02-21 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition
To Be Published
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9NGT
 | | Crystal structure of CRBN-DDB1 and FPFT-2216 in complex with mTOR | | 分子名称: | (3S)-3-[(4M)-4-(4-methoxythiophen-3-yl)-1H-1,2,3-triazol-1-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Petzold, G, Trenh, P, Bunker, R.D, Tsai, J.H.C. | | 登録日 | 2025-02-22 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition
To Be Published
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9NFQ
 | | Crystal structure of CRBN-DDB1 and MRT-3486 in complex with NEK7 | | 分子名称: | (3S)-N-{[(4R)-3-(2,4-dioxo-1,3-diazinan-1-yl)imidazo[1,2-a]pyridin-7-yl]methyl}-2-(phenylmethanesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, DNA damage-binding protein 1, ... | | 著者 | Quan, C, Petzold, G, Bunker, R.D, Wiedmer, L, Gainza, P, Tsai, J.H.C. | | 登録日 | 2025-02-21 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition
To Be Published
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8SWS
 | | Structure of K. lactis PNP S42E-H98R variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate | | 分子名称: | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION | | 著者 | Fedorov, E, Ghosh, A. | | 登録日 | 2023-05-19 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
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8AG2
 | | Crystal structure of the BPTF bromodomain in complex with BI-7190 | | 分子名称: | 5-[3-methoxy-4-[1-(4-methylpiperazin-1-yl)cyclopropyl]phenyl]-1,3,4-trimethyl-pyridin-2-one, Nucleosome-remodeling factor subunit BPTF | | 著者 | Bader, G, Boettcher, J, Wolkerstorfer, B. | | 登録日 | 2022-07-19 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.025 Å) | | 主引用文献 | Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments.
Chemmedchem, 18, 2023
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8SWT
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6BPY
 | | Aspergillus fumigatus Thioredoxin Reductase | | 分子名称: | ACETATE ION, D-MALATE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Marshall, A.C, Bruning, J.B. | | 登録日 | 2017-11-27 | | 公開日 | 2019-01-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | | 主引用文献 | Structure, Mechanism, and Inhibition ofAspergillus fumigatusThioredoxin Reductase.
Antimicrob.Agents Chemother., 63, 2019
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1RTD
 | | STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE | | 分子名称: | DNA PRIMER FOR REVERSE TRANSCRIPTASE, DNA TEMPLATE FOR REVERSE TRANSCRIPTASE, MAGNESIUM ION, ... | | 著者 | Chopra, R, Huang, H, Verdine, G.L, Harrison, S.C. | | 登録日 | 1998-08-26 | | 公開日 | 1998-12-09 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.
Science, 282, 1998
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6FF1
 | | CsoZ metallochaperone | | 分子名称: | CALCIUM ION, CsoZ | | 著者 | Pelicioli-Riboldi, G, Basle, A, Waldron, K. | | 登録日 | 2018-01-03 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The copper homeostasis system of Staphylococcus aureus:
Two putative metallochaperones with contrasting copper binding properties.
To Be Published
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3AAQ
 | | Crystal structure of Lp1NTPDase from Legionella pneumophila in complex with the inhibitor ARL 67156 | | 分子名称: | 5'-O-[(R)-{[(R)-[dibromo(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-N,N-diethyladenosine, Ectonucleoside triphosphate diphosphohydrolase I | | 著者 | Vivian, J.P, Beddoe, T, Rossjohn, J. | | 登録日 | 2009-11-24 | | 公開日 | 2010-02-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases
Structure, 18, 2010
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8SWP
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8SWR
 | | Structure of K. lactis PNP S42E variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate | | 分子名称: | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, GUANINE, Purine nucleoside phosphorylase, ... | | 著者 | Fedorov, E, Ghosh, A. | | 登録日 | 2023-05-19 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
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8SWQ
 | | Structure of K. lactis PNP bound to transition state analog DADMe-IMMUCILLIN H and sulfate | | 分子名称: | 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, GLYCEROL, Purine nucleoside phosphorylase, ... | | 著者 | Fedorov, E, Ghosh, A. | | 登録日 | 2023-05-19 | | 公開日 | 2023-10-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
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9DBY
 | | ncPRC1RYBP bound to singly modified H2AK119Ub nucleosome | | 分子名称: | DNA (187-MER), E3 ubiquitin-protein ligase RING2, Histone H2A type 1, ... | | 著者 | Godinez-Lopez, V, Valencia-Sanchez, M.I, Armache, J.P, Armache, K.-J. | | 登録日 | 2024-08-24 | | 公開日 | 2024-11-20 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1.
Nature, 636, 2024
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6FF2
 | | CopZ metallochaperone | | 分子名称: | COPPER (I) ION, Copper chaperone CopZ, MAGNESIUM ION | | 著者 | Pelicioli-Riboldi, G, Basle, A, Waldron, K. | | 登録日 | 2018-01-03 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The copper homeostasis system of Staphylococcus aureus:
Two putative metallochaperones with contrasting copper binding properties.
To Be Published
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8SWU
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