PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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6RVL	Crystal structure of hCA II with Urea, N-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-?N'-phenyl- 分子名称: 1-[1,1-bis(oxidanyl)-3~{H}-2,1-benzoxaborol-1-ium-6-yl]-3-phenyl-thiourea, Carbonic anhydrase 2, ZINC ION 著者 Di Fiore, A, De Simone, G. 登録日 2019-05-31 公開日 2019-08-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity. J Enzyme Inhib Med Chem, 34, 2019
3FH6	Crystal structure of the resting state maltose transporter from E. coli 分子名称: Maltose transport system permease protein malF, Maltose transport system permease protein malG, Maltose/maltodextrin import ATP-binding protein malK 著者 Khare, D, Oldham, M.L, Orelle, C, Davidson, A.L, Chen, J. 登録日 2008-12-08 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Alternating access in maltose transporter mediated by rigid-body rotations. Mol.Cell, 33, 2009
6RXM	Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16-Acetyl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
2HBN	Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex 分子名称: 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', THALLIUM (I) ION 著者 Gill, M.L, Strobel, S.A, Loria, J.P. 登録日 2006-06-14 公開日 2006-09-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex. Nucleic Acids Res., 34, 2006
5KPM	Glycogen Synthase Kinase 3 beta Complexed with BRD3731 分子名称: (4~{S})-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta 著者 Lakshminarasimhan, D, White, A, Nadupalli, A, Suto, R.K. 登録日 2016-07-04 公開日 2018-03-14 最終更新日 2018-03-21 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
5KPL	Glycogen Synthase Kinase 3 beta Complexed with BRD0705 分子名称: (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta 著者 Lakshminarasimhan, D, White, A, Nadupalli, A, Suto, R.K. 登録日 2016-07-04 公開日 2018-03-14 最終更新日 2018-03-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
6WA8	Crystal structure of the E. coli transcription termination factor Rho 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Transcription termination factor Rho 著者 Fan, C, Rees, D.C. 登録日 2020-03-24 公開日 2020-09-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of the Escherichia coli transcription termination factor Rho. Acta Crystallogr.,Sect.F, 76, 2020
6J0J	Crystal structure of Proliferating Cell Nuclear Antigen from Leishmania donovani with an unexplained density near residues Pro229,Pr0267 and Ala285 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Proliferating cell nuclear antigen 著者 Iqbal, N, Sharma, S, Singh, T.P. 登録日 2018-12-24 公開日 2019-01-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of Proliferating Cell Nuclear Antigen from Leishmania donovani with an unexplained density near residues Pro229,Pr0267 and Ala285 To Be Published
8ISI	Photochromobilin-free form of Arabidopsis thaliana phytochrome A - apo-AtphyA 分子名称: Phytochrome A 著者 Zhang, Y, Ma, C, Zhao, J, Gao, N, Wang, J. 登録日 2023-03-20 公開日 2023-08-09 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.77 Å) 主引用文献 Structural insights into plant phytochrome A as a highly sensitized photoreceptor. Cell Res., 33, 2023
2VDW	Guanosine N7 methyl-transferase sub-complex (D1-D12) of the vaccinia virus mRNA capping enzyme 分子名称: MRNA-CAPPING ENZYME SMALL SUBUNIT, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 De la Pena, M, Kyrieleis, O.J.P, Cusack, S. 登録日 2007-10-12 公開日 2008-05-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Insights Into the Mechanism and Evolution of the Vaccinia Virus Mrna CAP N7 Methyl- Transferase. Embo J., 26, 2007
5KPK	Glycogen Synthase Kinase 3 beta Complexed with BRD0209 分子名称: (4~{S})-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta 著者 Lakshminarasimhan, D, White, A, Nadupalli, A, Suto, R.K. 登録日 2016-07-04 公開日 2018-03-14 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
5GH9	Crystal structure of CBP Bromodomain with H3K56ac peptide 分子名称: CREB-binding protein, Histone H3 著者 Xu, L. 登録日 2016-06-19 公開日 2017-06-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.451 Å) 主引用文献 Structural insight into CBP bromodomain-mediated recognition of acetylated histone H3K56ac FEBS J., 2017
2Y0M	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN DOSAGE COMPENSATION FACTORS MSL1 AND MOF 分子名称: ACETYL COENZYME *A, MALE-SPECIFIC LETHAL 1 HOMOLOG, PROBABLE HISTONE ACETYLTRANSFERASE MYST1, ... 著者 Kadlec, J, Hallacli, E, Lipp, M, Holz, H, Sanchez Weatherby, J, Cusack, S, Akhtar, A. 登録日 2010-12-03 公開日 2011-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Mof and Msl3 Recruitment Into the Dosage Compensation Complex by Msl1. Nat.Struct.Mol.Biol., 18, 2011
5GK9	Crystal structure of human HBO1 in complex with BRPF2 分子名称: ACETYL COENZYME *A, BRD1 protein, Histone acetyltransferase KAT7, ... 著者 Tao, Y, Zhu, J, Xu, S, Ding, J. 登録日 2016-07-04 公開日 2017-03-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2. Nucleic Acids Res., 45, 2017
4RN1	Crystal structure of S39D HDAC8 in complex with a largazole analogue. 分子名称: (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,20,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione, GLYCEROL, Histone deacetylase 8, ... 著者 Decroos, C, Christianson, D.W. 登録日 2014-10-22 公開日 2015-04-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54, 2015
2LBS	Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III (Rnt1p) in complex with AAGU tetraloop hairpin 分子名称: RNA (32-MER), Ribonuclease 3 著者 Wang, Z, Hartman, E, Roy, K, Chanfreau, G, Feigon, J. 登録日 2011-04-06 公開日 2011-08-31 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure of a Yeast RNase III dsRBD Complex with a Noncanonical RNA Substrate Provides New Insights into Binding Specificity of dsRBDs. Structure, 19, 2011
5LAS	HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3) 分子名称: Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ... 著者 Chowdhury, R, Schofield, C.J. 登録日 2016-06-14 公開日 2016-08-31 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016
2Y0N	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN DOSAGE COMPENSATION FACTORS MSL1 AND MSL3 分子名称: MALE-SPECIFIC LETHAL 1 HOMOLOG, MALE-SPECIFIC LETHAL 3 HOMOLOG 著者 Kadlec, J, Hallacli, E, Lipp, M, Holz, H, Sanchez Weatherby, J, Cusack, S, Akhtar, A. 登録日 2010-12-04 公開日 2011-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural Basis for Mof and Msl3 Recruitment Into the Dosage Compensation Complex by Msl1. Nat.Struct.Mol.Biol., 18, 2011
6V8B	Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 1 分子名称: 4-(2-{[(1R)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino}ethyl)benzene-1-sulfonamide, CHLORIDE ION, Histone acetyltransferase p300, ... 著者 Gardberg, A.S. 登録日 2019-12-10 公開日 2020-04-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. Chemmedchem, 15, 2020
6CHT	HNF4alpha in complex with the corepressor EBP1 fragment 分子名称: Hepatocyte nuclear factor 4-alpha, LAURIC ACID, Proliferation-associated protein 2G4 著者 Chi, Y.I, Singh, P, Lee, I.K. 登録日 2018-02-22 公開日 2019-02-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.174 Å) 主引用文献 ErbB3-binding protein 1 (EBP1) represses HNF4 alpha-mediated transcription and insulin secretion in pancreatic beta-cells. J.Biol.Chem., 294, 2019
5FJ6	Structure of the P2 polymerase inside in vitro assembled bacteriophage phi6 polymerase complex 分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Ilca, S, Kotecha, A, Sun, X, Poranen, M.P, Stuart, D.I, Huiskonen, J.T. 登録日 2015-10-06 公開日 2015-11-04 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Localized Reconstruction of Subunits from Electron Cryomicroscopy Images of Macromolecular Complexes. Nat.Commun., 6, 2015
8J8Q	Structure of the four-component Paf1 complex from Saccharomyces eubayanus 分子名称: CDC73-like protein, CTR9-like protein, PAF1-like protein, ... 著者 Wang, Z, Qin, Y, Zhou, Y, Cao, Y. 登録日 2023-05-02 公開日 2023-05-24 最終更新日 2023-06-14 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural Basis of the Transcriptional Elongation Factor Paf1 Core Complex from Saccharomyces eubayanus . Int J Mol Sci, 24, 2023
5FU7	drosophila nanos NBR peptide bound to the NOT module of the human CCR4-NOT complex 分子名称: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3, ... 著者 Raisch, T, Bhandari, D, Sabath, K, Helms, S, Valkov, E, Weichenrieder, O, Izaurralde, E. 登録日 2016-01-21 公開日 2016-03-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos Embo J., 35, 2016
8WDX	Crystal structure of human FABP4 complexed with C3 分子名称: 1,2-ETHANEDIOL, 2-[(3-chloranyl-2-phenyl-phenyl)amino]-6-methyl-benzoic acid, Fatty acid-binding protein, ... 著者 Xie, H, Chen, G.F, Xu, Y.C. 登録日 2023-09-16 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3. Eur.J.Med.Chem., 264, 2023
8WE3	Crystal structure of human FABP4 complexed with C7 分子名称: 2-[(3-chloranyl-2-phenyl-phenyl)amino]-5-fluoranyl-benzoic acid, Fatty acid-binding protein, adipocyte 著者 Xie, H, Chen, G.F, Xu, Y.C, Li, M.J. 登録日 2023-09-16 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3. Eur.J.Med.Chem., 264, 2023

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