6CHT

HNF4alpha in complex with the corepressor EBP1 fragment

Summary for 6CHT

Entry DOI	10.2210/pdb6cht/pdb
Descriptor	Hepatocyte nuclear factor 4-alpha, Proliferation-associated protein 2G4, LAURIC ACID, ... (4 entities in total)
Functional Keywords	hnf4alpha, ebp1, nuclear receptor, co-repressor, protein-protein interaction, gene regulation, insulin secretion, diabetes, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	20
Total formula weight	450999.28
Authors	Chi, Y.I.,Singh, P.,Lee, I.K. (deposition date: 2018-02-22, release date: 2019-02-27, Last modification date: 2023-10-04)
Primary citation	Han, E.H.,Singh, P.,Lee, I.K.,Urrutia, R.,Chi, Y.I. ErbB3-binding protein 1 (EBP1) represses HNF4 alpha-mediated transcription and insulin secretion in pancreatic beta-cells. J.Biol.Chem., 294:13983-13994, 2019 Cited by PubMed: 31362984 DOI: 10.1074/jbc.RA119.009558 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.174 Å)

Structure validation