Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6CHT

HNF4alpha in complex with the corepressor EBP1 fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003323	biological_process	type B pancreatic cell development
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0050796	biological_process	regulation of insulin secretion
A	0055088	biological_process	lipid homeostasis
A	0070365	biological_process	hepatocyte differentiation
B	0003323	biological_process	type B pancreatic cell development
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0050796	biological_process	regulation of insulin secretion
B	0055088	biological_process	lipid homeostasis
B	0070365	biological_process	hepatocyte differentiation
D	0003323	biological_process	type B pancreatic cell development
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0050796	biological_process	regulation of insulin secretion
D	0055088	biological_process	lipid homeostasis
D	0070365	biological_process	hepatocyte differentiation
E	0003323	biological_process	type B pancreatic cell development
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0050796	biological_process	regulation of insulin secretion
E	0055088	biological_process	lipid homeostasis
E	0070365	biological_process	hepatocyte differentiation
G	0003323	biological_process	type B pancreatic cell development
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0050796	biological_process	regulation of insulin secretion
G	0055088	biological_process	lipid homeostasis
G	0070365	biological_process	hepatocyte differentiation
H	0003323	biological_process	type B pancreatic cell development
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0050796	biological_process	regulation of insulin secretion
H	0055088	biological_process	lipid homeostasis
H	0070365	biological_process	hepatocyte differentiation
J	0003323	biological_process	type B pancreatic cell development
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0050796	biological_process	regulation of insulin secretion
J	0055088	biological_process	lipid homeostasis
J	0070365	biological_process	hepatocyte differentiation
K	0003323	biological_process	type B pancreatic cell development
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0050796	biological_process	regulation of insulin secretion
K	0055088	biological_process	lipid homeostasis
K	0070365	biological_process	hepatocyte differentiation
M	0003323	biological_process	type B pancreatic cell development
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0050796	biological_process	regulation of insulin secretion
M	0055088	biological_process	lipid homeostasis
M	0070365	biological_process	hepatocyte differentiation
N	0003323	biological_process	type B pancreatic cell development
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0050796	biological_process	regulation of insulin secretion
N	0055088	biological_process	lipid homeostasis
N	0070365	biological_process	hepatocyte differentiation
P	0003323	biological_process	type B pancreatic cell development
P	0003700	molecular_function	DNA-binding transcription factor activity
P	0050796	biological_process	regulation of insulin secretion
P	0055088	biological_process	lipid homeostasis
P	0070365	biological_process	hepatocyte differentiation
Q	0003323	biological_process	type B pancreatic cell development
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0050796	biological_process	regulation of insulin secretion
Q	0055088	biological_process	lipid homeostasis
Q	0070365	biological_process	hepatocyte differentiation
S	0003323	biological_process	type B pancreatic cell development
S	0003700	molecular_function	DNA-binding transcription factor activity
S	0050796	biological_process	regulation of insulin secretion
S	0055088	biological_process	lipid homeostasis
S	0070365	biological_process	hepatocyte differentiation
T	0003323	biological_process	type B pancreatic cell development
T	0003700	molecular_function	DNA-binding transcription factor activity
T	0050796	biological_process	regulation of insulin secretion
T	0055088	biological_process	lipid homeostasis
T	0070365	biological_process	hepatocyte differentiation
V	0003323	biological_process	type B pancreatic cell development
V	0003700	molecular_function	DNA-binding transcription factor activity
V	0050796	biological_process	regulation of insulin secretion
V	0055088	biological_process	lipid homeostasis
V	0070365	biological_process	hepatocyte differentiation
W	0003323	biological_process	type B pancreatic cell development
W	0003700	molecular_function	DNA-binding transcription factor activity
W	0050796	biological_process	regulation of insulin secretion
W	0055088	biological_process	lipid homeostasis
W	0070365	biological_process	hepatocyte differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue DAO A 500

Chain	Residue
A	SER181
A	GLN185
A	ALA223
A	ARG226
A	LEU235
A	LEU236
A	GLY237
A	VAL255

site_id	AC2
Number of Residues	8
Details	binding site for residue DAO B 500

Chain	Residue
B	GLN185
B	LEU220
B	ALA223
B	ARG226
B	LEU236
B	GLY237
B	MET252
B	SER181

site_id	AC3
Number of Residues	5
Details	binding site for residue DAO D 500

Chain	Residue
D	SER181
D	GLN185
D	LEU219
D	ARG226
D	LEU236

site_id	AC4
Number of Residues	8
Details	binding site for residue DAO J 500

Chain	Residue
J	VAL178
J	SER181
J	MET182
J	GLN185
J	LEU220
J	ARG226
J	MET342
J	GLN345

site_id	AC5
Number of Residues	13
Details	binding site for Di-peptide DAO E 500 and ARG E 226

Chain	Residue
E	SER181
E	GLN185
E	LEU220
E	GLY222
E	ALA223
E	THR224
E	LYS225
E	SER227
E	MET228
E	LEU235
E	LEU236
E	GLY237
E	MET252

site_id	AC6
Number of Residues	15
Details	binding site for Di-peptide DAO G 500 and ARG G 226

Chain	Residue
G	SER181
G	MET182
G	GLN185
G	LEU219
G	GLY222
G	ALA223
G	THR224
G	LYS225
G	SER227
G	LEU235
G	LEU236
G	GLY237
G	VAL255
G	SER256
G	ILE259

site_id	AC7
Number of Residues	9
Details	binding site for Di-peptide DAO H 500 and GLY H 237

Chain	Residue
H	VAL178
H	GLN185
H	LEU220
H	ALA223
H	ARG226
H	LEU235
H	LEU236
H	ASN238
H	ASP239

site_id	AC8
Number of Residues	12
Details	binding site for Di-peptide DAO H 500 and ARG H 226

Chain	Residue
H	VAL178
H	GLN185
H	LEU220
H	GLY222
H	ALA223
H	THR224
H	LYS225
H	SER227
H	MET228
H	LEU235
H	LEU236
H	GLY237

site_id	AC9
Number of Residues	15
Details	binding site for Di-peptide DAO K 500 and ARG K 226

Chain	Residue
D	ARG168
K	SER181
K	MET182
K	GLN185
K	GLY222
K	ALA223
K	THR224
K	LYS225
K	SER227
K	MET228
K	LEU235
K	LEU236
K	GLY237
K	MET252
K	VAL255

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"12740371","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21708125","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)