2BYI
| 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone | 分子名称: | 3-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 4-SULFAMOYL-BENZYLAMIDE, HEAT SHOCK PROTEIN HSP90-ALPHA | 著者 | Brough, P.A, Barril, X, Beswick, M, Dymock, B.W, Drysdale, M.J, Wright, L, Grant, K, Massey, A, Surgenor, A, Workman, P. | 登録日 | 2005-08-02 | 公開日 | 2005-10-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | 3-(5-Chloro-2,4-Dihydroxyphenyl)-Pyrazole-4-Carboxamides as Inhibitors of the Hsp90 Molecular Chaperone. Bioorg.Med.Chem.Lett., 15, 2005
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2BYJ
| Ornithine aminotransferase mutant Y85I | 分子名称: | ORNITHINE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Markova, M, Peneff, C, Hewlins, M.J.E, Schirmer, T, John, R.A. | 登録日 | 2005-08-02 | 公開日 | 2005-09-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Determinants of Substrate Specificity in Omega-Aminotransferases. J.Biol.Chem., 280, 2005
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2BYK
| Histone fold heterodimer of the Chromatin Accessibility Complex | 分子名称: | CHRAC-14, CHRAC-16, SULFATE ION | 著者 | Fernandez-Tornero, C, Hartlepp, K.F, Grune, T, Eberharter, A, Becker, P.B, Muller, C.W. | 登録日 | 2005-08-03 | 公開日 | 2005-11-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Histone Fold Subunits of Drosophila Chrac Facilitate Nucleosome Sliding Through Dynamic DNA Interactions. Mol.Cell.Biol., 25, 2005
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2BYL
| Structure of ornithine aminotransferase triple mutant Y85I Y55A G320F | 分子名称: | ORNITHINE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Markova, M, Peneff, C, Hewlins, M.J.E, Schirmer, T, John, R.A. | 登録日 | 2005-08-03 | 公開日 | 2005-09-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Determinants of Substrate Specificity in Omega-Aminotransferases. J.Biol.Chem., 280, 2005
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2BYM
| Histone fold heterodimer of the Chromatin Accessibility Complex | 分子名称: | CADMIUM ION, CHRAC-14, CHRAC-16 | 著者 | Fernandez-Tornero, C, Hartlepp, K.F, Grune, T, Eberharter, A, Becker, P.B, Muller, C.W. | 登録日 | 2005-08-03 | 公開日 | 2005-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Histone Fold Subunits of Drosophila Chrac Facilitate Nucleosome Sliding Through Dynamic DNA Interactions. Mol.Cell.Biol., 25, 2005
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2BYN
| Crystal structure of apo AChBP from Aplysia californica | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAETHYLENE GLYCOL, SOLUBLE ACETYLCHOLINE RECEPTOR, ... | 著者 | Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. | 登録日 | 2005-08-03 | 公開日 | 2005-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
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2BYO
| Crystal structure of Mycobacterium tuberculosis lipoprotein LppX (Rv2945c) | 分子名称: | ACETATE ION, ALPHA-LINOLENIC ACID, D-MALATE, ... | 著者 | Sulzenbacher, G, Canaan, S, Roig-Zamboni, V, Maurin, D, Gicquel, B, Bourne, Y. | 登録日 | 2005-08-03 | 公開日 | 2006-03-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Lppx is a Lipoprotein Required for the Translocation of Phthiocerol Dimycocerosates to the Surface of Mycobacterium Tuberculosis. Embo J., 25, 2006
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2BYP
| Crystal structure of Aplysia californica AChBP in complex with alpha- conotoxin ImI | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-CONOTOXIN IMI, SOLUBLE ACETYLCHOLINE RECEPTOR | 著者 | Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. | 登録日 | 2005-08-03 | 公開日 | 2005-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
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2BYQ
| Crystal structure of Aplysia californica AChBP in complex with epibatidine | 分子名称: | EPIBATIDINE, SOLUBLE ACETYLCHOLINE RECEPTOR | 著者 | Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. | 登録日 | 2005-08-03 | 公開日 | 2005-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
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2BYR
| CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA in complex with methyllycaconitine | 分子名称: | ACETYLCHOLINE-BINDING PROTEIN, METHYLLYCACONITINE | 著者 | Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. | 登録日 | 2005-08-03 | 公開日 | 2005-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
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2BYS
| CRYSTAL STRUCTURE OF ACHBP FROM APLYSIA CALIFORNICA IN complex with lobeline | 分子名称: | ACETYLCHOLINE-BINDING PROTEIN, LOBELINE | 著者 | Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. | 登録日 | 2005-08-04 | 公開日 | 2005-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
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2BYT
| Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation | 分子名称: | LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ... | 著者 | Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S. | 登録日 | 2005-08-04 | 公開日 | 2005-09-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation. Nat.Struct.Mol.Biol., 12, 2005
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2BYU
| Negative stain EM reconstruction of M.tuberculosis Acr1(Hsp 16.3) fitted with wheat sHSP dimer | 分子名称: | HEAT SHOCK PROTEIN 16.9B | 著者 | Kennaway, C.K, Benesch, J.L.P, Gohlke, U, Wang, L, Robinson, C.V, Orlova, E.V, Saibil, H.R, Keep, N.H. | 登録日 | 2005-08-05 | 公開日 | 2005-08-22 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (16.5 Å) | 主引用文献 | Dodecameric Structure of the Small Heat Shock Protein Acr1 from Mycobacterium Tuberculosis. J.Biol.Chem., 280, 2005
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2BYV
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2BYW
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2BYX
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2BYY
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2BYZ
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2BZ0
| Crystal Structure of E. coli GTP cyclohydrolase II in complex with GTP analogue, GMPcPP, and Zinc | 分子名称: | GTP CYCLOHYDROLASE II, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | 著者 | Ren, J, Kotaka, M, Lockyer, M, Lamb, H.K, Hawkins, A.R, Stammers, D.K. | 登録日 | 2005-08-09 | 公開日 | 2005-08-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | GTP Cyclohydrolase II Structure and Mechanism. J.Biol.Chem., 280, 2005
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2BZ1
| CRYSTAL STRUCTURE OF APO E. COLI GTP CYCLOHYDROLASE II | 分子名称: | 2-AMINOETHANESULFONIC ACID, GLYCEROL, GTP CYCLOHYDROLASE II, ... | 著者 | Ren, J, Kotaka, M, Lockyer, M, Lamb, H.K, Hawkins, A.R, Stammers, D.K. | 登録日 | 2005-08-09 | 公開日 | 2005-08-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | GTP Cyclohydrolase II Structure and Mechanism. J.Biol.Chem., 280, 2005
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2BZ2
| Solution structure of NELF E RRM | 分子名称: | NEGATIVE ELONGATION FACTOR E | 著者 | Schweimer, K, Rao, J.N, Neumann, L, Rosch, P, Wohrl, B.M. | 登録日 | 2005-08-10 | 公開日 | 2006-08-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription. Biochem. J., 400, 2006
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2BZ3
| Structure of E.coli KAS I H298E mutant in complex with C12 fatty acid | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID, ... | 著者 | Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. | 登録日 | 2005-08-10 | 公開日 | 2006-02-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
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2BZ4
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2BZ5
| Structure-based Discovery of a New Class of Hsp90 Inhibitors | 分子名称: | 2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE, HEAT SHOCK PROTEIN HSP90-ALPHA | 著者 | Barril, X, Brough, P, Drysdale, M, Hubbard, R.E, Massey, A, Surgenor, A, Wright, L. | 登録日 | 2005-08-11 | 公開日 | 2005-10-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Based Discovery of a New Class of Hsp90 Inhibitors. Bioorg.Med.Chem.Lett., 15, 2005
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2BZ6
| Orally available Factor7a inhibitor | 分子名称: | (R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC ACID, BLOOD COAGULATION FACTOR VIIA, CALCIUM ION, ... | 著者 | Groebke-Zbinden, K, Obst-Sander, U, Hilpert, K, Kuehne, H, Banner, D.W, Boehm, H.J, Stahl, M, Ackermann, J, Alig, L, Weber, L, Wessel, H.P, Riederer, M.A, Tschopp, T.B, Lave, T. | 登録日 | 2005-08-11 | 公開日 | 2006-02-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Dose-Dependant Antithrombotic Activity of an Orally Active Tissue Factor/Factor Viia Inhibitor without Concomitant Enhancement of Bleeding Propensity. Bioorg.Med.Chem., 14, 2006
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