8ELS
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![BU of 8els by Molmil](/molmil-images/mine/8els) | HRAS R97A Crystal Form 1 R-state | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Davis, D, Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8ELK
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![BU of 8elk by Molmil](/molmil-images/mine/8elk) | HRAS R97F Crystal Form 1 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8ELX
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![BU of 8elx by Molmil](/molmil-images/mine/8elx) | HRAS R97I Crystal Form 1 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.975 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8ELT
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![BU of 8elt by Molmil](/molmil-images/mine/8elt) | HRAS R97G Crystal Form 2 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8ELV
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![BU of 8elv by Molmil](/molmil-images/mine/8elv) | HRAS R97I Crystal Form 2 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.153 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8EM0
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![BU of 8em0 by Molmil](/molmil-images/mine/8em0) | HRAS R97V Crystal Form 1 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8ELR
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![BU of 8elr by Molmil](/molmil-images/mine/8elr) | HRAS R97F Crystal Form 2 | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Johnson, C.W, Mattos, C. | 登録日 | 2022-09-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
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8B69
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![BU of 8b69 by Molmil](/molmil-images/mine/8b69) | Heterotetramer of K-Ras4B(G12V) and Rgl2(RBD) | 分子名称: | Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Tariq, M, Fairall, L, Romartinez-Alonso, B, Dominguez, C, Schwabe, J.W.R, Tanaka, K. | 登録日 | 2022-09-26 | 公開日 | 2023-08-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator. Life Sci Alliance, 7, 2024
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8EM4
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![BU of 8em4 by Molmil](/molmil-images/mine/8em4) | Cryo-EM structure of LRP2 at pH 7.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Beenken, A, Cerutti, G, Brasch, J, Fitzpatrick, A.W, Barasch, J, Shapiro, L. | 登録日 | 2022-09-26 | 公開日 | 2023-02-08 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structures of LRP2 reveal a molecular machine for endocytosis. Cell, 186, 2023
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8B5Y
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![BU of 8b5y by Molmil](/molmil-images/mine/8b5y) | SHP2 in complex with allosteric imidazopyrazine inhibitor | 分子名称: | (1~{S})-1'-[5-[2-(trifluoromethyl)pyridin-3-yl]sulfanyl-3~{H}-imidazo[4,5-b]pyrazin-2-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine, FORMIC ACID, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Torrente, E, Petrocchi, A. | 登録日 | 2022-09-25 | 公開日 | 2023-01-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8B5R
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![BU of 8b5r by Molmil](/molmil-images/mine/8b5r) | p97-p37-SPI substrate complex | 分子名称: | I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... | 著者 | van den Boom, J, Marini, G, Meyer, H, Saibil, H. | 登録日 | 2022-09-24 | 公開日 | 2023-06-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structural basis of ubiquitin-independent PP1 complex disassembly by p97. Embo J., 42, 2023
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8GYM
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![BU of 8gym by Molmil](/molmil-images/mine/8gym) | Cryo-EM structure of Tetrahymena thermophila respiratory mega-complex MC IV2+(I+III2+II)2 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Wu, M.C, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2022-09-23 | 公開日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae. Nat Commun, 14, 2023
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8ELC
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![BU of 8elc by Molmil](/molmil-images/mine/8elc) | Human JNK2 bound to covalent inhibitor YL2056 | 分子名称: | 4-(dimethylamino)-N-{4-[(3S)-3-({4-[(8R)-2-phenylpyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amino)pyrrolidine-1-carbonyl]phenyl}butanamide, Mitogen-activated protein kinase 9 | 著者 | Li, L, Gurbani, D, Westover, K.D. | 登録日 | 2022-09-23 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.072 Å) | 主引用文献 | Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66, 2023
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8EKY
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![BU of 8eky by Molmil](/molmil-images/mine/8eky) | |
8GYE
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![BU of 8gye by Molmil](/molmil-images/mine/8gye) | |
8EKT
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![BU of 8ekt by Molmil](/molmil-images/mine/8ekt) | CYP51 from Acanthamoeba castellanii in complex with the tetrazole-based IND inhibitor VT-1161(VT1) | 分子名称: | (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, PROTOPORPHYRIN IX CONTAINING FE, sterol 14a-demethylase | 著者 | Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. | 登録日 | 2022-09-21 | 公開日 | 2023-08-02 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14 alpha-Demethylase as a Key Drug Target. J.Med.Chem., 67, 2024
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8GXQ
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![BU of 8gxq by Molmil](/molmil-images/mine/8gxq) | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | 登録日 | 2022-09-21 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (5.04 Å) | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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8GXS
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![BU of 8gxs by Molmil](/molmil-images/mine/8gxs) | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | 登録日 | 2022-09-21 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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8GXX
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![BU of 8gxx by Molmil](/molmil-images/mine/8gxx) | 3 nucleotide-bound V1EG of V/A-ATPase from Thermus thermophilus. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Nakanishi, A, Kishikawa, J, Mitsuoka, K, Yokoyama, K. | 登録日 | 2022-09-21 | 公開日 | 2023-01-25 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. J.Biol.Chem., 299, 2023
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8GY7
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![BU of 8gy7 by Molmil](/molmil-images/mine/8gy7) | Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | 分子名称: | CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. | 登録日 | 2022-09-21 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Res., 33, 2023
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8GXU
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![BU of 8gxu by Molmil](/molmil-images/mine/8gxu) | 1 ATP-bound V1EG of V/A-ATPase from Thermus thermophilus | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, SULFATE ION, V-type ATP synthase alpha chain, ... | 著者 | Nakanishi, A, Kishikawa, J, Mitsuoka, K, Yokoyama, K. | 登録日 | 2022-09-21 | 公開日 | 2023-01-25 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. J.Biol.Chem., 299, 2023
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8GXY
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![BU of 8gxy by Molmil](/molmil-images/mine/8gxy) | 2 sulfate-bound V1EG of V/A-ATPase from Thermus thermophilus. | 分子名称: | SULFATE ION, V-type ATP synthase alpha chain, V-type ATP synthase beta chain, ... | 著者 | Nakanishi, A, Kishikawa, J, Mitsuoka, K, Yokoyama, K. | 登録日 | 2022-09-21 | 公開日 | 2023-01-25 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. J.Biol.Chem., 299, 2023
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8GXW
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![BU of 8gxw by Molmil](/molmil-images/mine/8gxw) | 2 ATP-bound V1EG of V/A-ATPase from Thermus thermophilus | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | 著者 | Nakanishi, A, Kishikawa, J, Mitsuoka, K, Yokoyama, K. | 登録日 | 2022-09-21 | 公開日 | 2023-01-25 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. J.Biol.Chem., 299, 2023
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8GXZ
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![BU of 8gxz by Molmil](/molmil-images/mine/8gxz) | 1 sulfate and 1 ATP bound V1EG of V/A-ATPase from Thermus thermophilus. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | 著者 | Nakanishi, A, Kishikawa, J, Mitsuoka, K, Yokoyama, K. | 登録日 | 2022-09-21 | 公開日 | 2023-01-25 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. J.Biol.Chem., 299, 2023
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8GY2
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![BU of 8gy2 by Molmil](/molmil-images/mine/8gy2) | Cryo-EM Structure of Membrane-Bound Alcohol Dehydrogenase from Gluconobacter oxydans | 分子名称: | Alcohol dehydrogenase (quinone), cytochrome c subunit, dehydrogenase subunit, ... | 著者 | Adachi, T, Miyata, T, Makino, F, Tanaka, H, Namba, K, Sowa, K, Kitazumi, Y, Shirai, O. | 登録日 | 2022-09-21 | 公開日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Experimental and Theoretical Insights into Bienzymatic Cascade for Mediatorless Bioelectrochemical Ethanol Oxidation with Alcohol and Aldehyde Dehydrogenases Acs Catalysis, 13, 2023
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