PDB: 22592 件ウェブページステータス検索Chemie searchBIRD

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3CG5	Crystal Structure of the Covalent Adduct Formed between TB B-lactamase and Clavulanate 分子名称: (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase, PHOSPHATE ION 著者 Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. 登録日 2008-03-04 公開日 2008-05-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate. Biochemistry, 47, 2008
3RV9	Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Ethyl R-Group 分子名称: 3-{[(1Z)-1-carboxybut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI 著者 Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) 登録日 2011-05-06 公開日 2012-05-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
2ZYQ	Crystal structure of the HsaC extradiol dioxygenase from M. tuberculosis 分子名称: D(-)-TARTARIC ACID, FE (II) ION, PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC 著者 D'Angelo, I, Yam, K.C, Eltis, L.D, Strynadka, N. 登録日 2009-01-28 公開日 2009-03-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. Plos Pathog., 5, 2009
3AFE	Crystal structure of the HsaA monooxygenase from M.tuberculosis 分子名称: Hydroxylase, putative 著者 D'Angelo, I, Lin, L.Y, Dresen, C, Tocheva, E.I, Eltis, L.D, Strynadka, N. 登録日 2010-02-28 公開日 2010-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism J.Biol.Chem., 285, 2010
4FX0	Crystal structure of M. tuberculosis transcriptional regulator MosR 分子名称: PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN 著者 Brugarolas, P, He, C. 登録日 2012-07-02 公開日 2012-09-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6981 Å) 主引用文献 The Oxidation-sensing Regulator (MosR) Is a New Redox-dependent Transcription Factor in Mycobacterium tuberculosis. J.Biol.Chem., 287, 2012
2WOQ	Porphobilinogen Synthase (HemB) in Complex with 5-acetamido-4- oxohexanoic acid (Alaremycin 2) 分子名称: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALAREMYCIN 2, ... 著者 Heinemann, I.U, Schulz, C, Schubert, W.-D, Heinz, D.W, Wang, Y.-G, Kobayashi, Y, Awa, Y, Wachi, M, Jahn, D, Jahn, M. 登録日 2009-07-27 公開日 2009-10-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrob. Agents Chemother., 54, 2010
5EP9	Crystal structure of the non-heme alpha ketoglutarate dependent epimerase SnoN from nogalamycin biosynthesis 分子名称: 2-OXOGLUTARIC ACID, ACETATE ION, FE (III) ION, ... 著者 Selvaraj, B, Lindqvist, Y, Niiranen, L, Siitonen, V, Metsa-Ketela, M, Schneider, G. 登録日 2015-11-11 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 113, 2016
3S04	Crystal structure of Escherichia coli type I signal peptidase in complex with an Arylomycin Lipoglycopeptide Antibiotic 分子名称: 14-methylhexadec-9-enoic acid, Glyco-Arylomycin, Signal peptidase I, ... 著者 Paetzel, M, Luo, C. 登録日 2011-05-13 公開日 2011-10-05 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. J.Am.Chem.Soc., 133, 2011
3SAD	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor 分子名称: 4-(2-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G 著者 Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2011-06-02 公開日 2012-11-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
1KNM	Streptomyces lividans Xylan Binding Domain cbm13 in Complex with Lactose 分子名称: ENDO-1,4-BETA-XYLANASE A, GLYCEROL, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose 著者 Notenboom, V, Boraston, A.B, Williams, S.J, Kilburn, D.G, Rose, D.R. 登録日 2001-12-19 公開日 2002-06-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding. Biochemistry, 41, 2002
2WP4	crystal structure of Rv3119 from Mycobacterium tuberculosis 分子名称: CALCIUM ION, GLYCEROL, MOLYBDOPTERIN-CONVERTING FACTOR SUBUNIT 2 1 著者 Cho, H.J, Kang, B.S. 登録日 2009-08-03 公開日 2010-09-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Crystal Structure of Rv3119 from Mycobacterium Tuberculosis To be Published
3SAZ	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor 分子名称: 4-(3-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G 著者 Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2011-06-03 公開日 2012-11-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
3SB0	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor 分子名称: 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G 著者 Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2011-06-03 公開日 2012-11-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
3C11	Yeast Hsp82 N-terminal domain-Geldanamycin complex: effects of mutants 98-99 KS-AA 分子名称: ATP-dependent molecular chaperone HSP82, GELDANAMYCIN, GLYCEROL 著者 Immormino, R.M, Gewirth, D.T. 登録日 2008-01-21 公開日 2008-07-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin To be Published
3S9I	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor 分子名称: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MAGNESIUM ION, Malate synthase G 著者 Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2011-06-01 公開日 2012-11-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
3S9Z	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-bromophenyl)-2,4-dioxobutanoic acid inhibitor 分子名称: 4-(2-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G 著者 Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2011-06-02 公開日 2012-11-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.793 Å) 主引用文献 Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
5EPA	Crystal structure of non-heme alpha ketoglutarate dependent carbocyclase SnoK from nogalamycin biosynthesis 分子名称: 2-OXOGLUTARIC ACID, FE (III) ION, MAGNESIUM ION, ... 著者 Selvaraj, B, Lindqvist, Y, Siitonen, V, Niiranen, L, Metsa-Ketela, M, Schneider, G. 登録日 2015-11-11 公開日 2016-05-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 113, 2016
5SCQ	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-614 分子名称: Dihydrofolate reductase, N-[2-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)ethanesulfonyl]acetamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-614 to be published
5SCU	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-888 分子名称: 4-(3-{4-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]butoxy}phenyl)butanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-888 to be published
5SCY	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1198 分子名称: 1,2-ETHANEDIOL, 1-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)piperidine-4-carboxylic acid, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1198 to be published
5SCW	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-916 分子名称: (2S)-4-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)butane-1,2-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-916 to be published
5SD2	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1236 (enantiomer) 分子名称: (2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1236 (enantiomer) to be published
5SD0	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1225 分子名称: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)propan-1-ol, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1225 to be published
5SCT	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783 分子名称: 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N-(dimethylsulfamoyl)propanamide, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783 to be published
5SD3	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088 分子名称: 1,2-ETHANEDIOL, 3-{2-[(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}oxetan-3-yl)methoxy]phenyl}propanoic acid, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088 to be published

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