PDB: 353 件ウェブページステータス検索Chemie searchBIRD

---

3QCS	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine 分子名称: 3-phosphoinositide-dependent protein kinase 1, 6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2H-indazol-3-amine, GLYCEROL, ... 著者 Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. 登録日 2011-01-17 公開日 2011-03-09 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.487 Å) 主引用文献 Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
3QKK	Spirochromane Akt Inhibitors 分子名称: GSK-3 beta peptide, N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(2R)-6-hydroxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,3'-piperidin]-1'-yl]propyl}-2,6-dimethylbenzenesulfonamide, RAC-alpha serine/threonine-protein kinase 著者 Kallan, N.C, Spencer, K.L, Blake, J.F, Xu, R, Heizer, J, Bencsik, J.R, Mitchell, I.S, Gloor, S.L, Martinson, M, Risom, T, Gross, S.D, Morales, T, Vigers, G.P.A, Brandhuber, B.J, Skelton, N.J. 登録日 2011-02-01 公開日 2011-03-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery and SAR of spirochromane Akt inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
3QD3	Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate 分子名称: 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... 著者 Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. 登録日 2011-01-17 公開日 2011-03-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
3TMO	The catalytic domain of human deubiquitinase DUBA 分子名称: OTU domain-containing protein 5 著者 Yin, J, Bosanac, I, Ma, X, Hymowitz, S, Starovasnik, M, Cochran, A. 登録日 2011-08-31 公開日 2012-01-11 最終更新日 2012-02-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat.Struct.Mol.Biol., 19, 2012
3U7X	Crystal structure of the human eIF4E-4EBP1 peptide complex without cap 分子名称: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, SULFATE ION, ... 著者 Siddiqui, N, Tempel, W, Nedyalkova, L, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Borden, K.L.B, Park, H, Structural Genomics Consortium (SGC) 登録日 2011-10-14 公開日 2011-11-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E. J.Mol.Biol., 415, 2012
7DL2	Cryo-EM structure of human TSC complex 分子名称: Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... 著者 Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. 登録日 2020-11-25 公開日 2020-12-16 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun, 12, 2021
3EBM	Crystal structure of human translationally controlled tumour associated protein (hTCTP) mutant E12V 分子名称: Translationally-controlled tumor protein 著者 Yang, B, Dong, X, Zhong, C, Ding, J. 登録日 2008-08-28 公開日 2009-06-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein. J.Biol.Chem., 284, 2009
7VV9	Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-05 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VVG	Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-06 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VV8	Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-04 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VVB	Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-05 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
8QB8	Lsp1 in native eisosome lattice bound to plasma membrane microdomain 分子名称: Sphingolipid long chain base-responsive protein LSP1 著者 Kefauver, J.M, Zou, L, Loewith, R.J, Defosses, A. 登録日 2023-08-24 公開日 2024-07-24 最終更新日 2024-08-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Nature, 632, 2024
8QB7	Pil1 in native eisosome lattice bound to plasma membrane microdomain 分子名称: Sphingolipid long chain base-responsive protein PIL1 著者 Kefauver, J.M, Zou, L, Loewith, R.J, Defosses, A. 登録日 2023-08-24 公開日 2024-07-24 最終更新日 2024-08-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Nature, 632, 2024
5NNY	Crystal structure of the phosphatase domain from the Legionella effector WipB 分子名称: WipB 著者 Pinotsis, N, Waksman, G, Prevost, M.S. 登録日 2017-04-10 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery. Sci Rep, 7, 2017
8AE6	Cryo-EM structure of the SEA complex wing (SEACIT) 分子名称: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ... 著者 Tafur, L, Loewith, R. 登録日 2022-07-12 公開日 2022-11-02 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Cryo-EM structure of the SEA complex. Nature, 611, 2022
8ADL	Cryo-EM structure of the SEA complex 分子名称: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ... 著者 Tafur, L, Loewith, R. 登録日 2022-07-08 公開日 2022-11-02 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Cryo-EM structure of the SEA complex. Nature, 611, 2022
3WDZ	Crystal Structure of Keap1 in Complex with phosphorylated p62 分子名称: Kelch-like ECH-associated protein 1, Peptide from Sequestosome-1 著者 Fukutomi, T, Takagi, K, Mizushima, T, Tanaka, K, Komatsu, M, Yamamoto, M. 登録日 2013-06-26 公開日 2013-09-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol.Cell, 51, 2013
6MIU	Crystal structure of p62 ZZ domain in complex with Arg-Glu peptide 分子名称: Sequestosome-1, Arg-Glu peptide chimera, ZINC ION 著者 Ahn, J, Zhang, Y, Kutateladze, T.G. 登録日 2018-09-20 公開日 2018-10-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun, 9, 2018
6MJ7	Crystal structure of p62 ZZ domain in complex with free arginine 分子名称: 1,4-DIETHYLENE DIOXIDE, ARGININE, Sequestosome-1, ... 著者 Ahn, J, Zhang, Y, Kutateladze, T.G. 登録日 2018-09-20 公開日 2018-10-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.412 Å) 主引用文献 ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun, 9, 2018
6C08	Zebrafish SLC38A9 with arginine bound in the cytosol open state 分子名称: ARGININE, Sodium-coupled neutral amino acid transporter 9, antibody Fab Heavy Chain, ... 著者 Lei, H.-T, Gonen, T. 登録日 2017-12-28 公開日 2018-06-20 実験手法 X-RAY DIFFRACTION (3.17 Å) 主引用文献 Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state. Nat. Struct. Mol. Biol., 25, 2018
8GXP	Complex structure of RORgama with betulinic acid 分子名称: Betulinic acid, Nuclear receptor ROR-gamma 著者 Zhang, X.L, Xu, C, Bai, F. 登録日 2022-09-20 公開日 2023-06-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR gamma antagonists. Eur.J.Med.Chem., 257, 2023
6LPF	The crystal structure of human cytoplasmic LRS 分子名称: 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, GLYCEROL, ... 著者 Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. 登録日 2020-01-10 公開日 2020-03-25 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48, 2020
8TXS	Solution NMR structure of designed peptide BH26 (RGVTVPHNGESKDYSV) 分子名称: BH26 peptide 著者 McShan, A.C, Torres, M.P. 登録日 2023-08-24 公開日 2023-09-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Generative beta-hairpin design using a residue-based physicochemical property landscape. Biophys.J., 2024
4PSI	PIH1D1/phospho-Tel2 complex 分子名称: PIH1 domain-containing protein 1, Telomere length regulation protein TEL2 homolog 著者 Smerdon, S.J, Boulton, S.J, Stach, L, Flower, T.G, Horejsi, Z. 登録日 2014-03-07 公開日 2014-04-23 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex. Cell Rep, 7, 2014
4PSF	PIH1D1 N-terminal domain 分子名称: PIH1 domain-containing protein 1 著者 Smerdon, S.J, Boulton, S.J, Stach, L, Flower, T.G, Horejsi, Z. 登録日 2014-03-07 公開日 2014-04-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.578 Å) 主引用文献 Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex. Cell Rep, 7, 2014

<6789101112131415>