7TT6
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![BU of 7tt6 by Molmil](/molmil-images/mine/7tt6) | BamABCDE bound to substrate EspP in the intermediate-open EspP state | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | 著者 | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | 登録日 | 2022-01-31 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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7C05
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![BU of 7c05 by Molmil](/molmil-images/mine/7c05) | Crystal structure of human Trap1 with DN203495 | 分子名称: | 1-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Kim, D, Kim, D, Kim, S.Y, Lee, J.H, Kang, B.H, Kang, S, Lee, C. | 登録日 | 2020-04-30 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg.Chem., 101, 2020
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7FJN
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![BU of 7fjn by Molmil](/molmil-images/mine/7fjn) | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | 登録日 | 2021-08-04 | 公開日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
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2XLP
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![BU of 2xlp by Molmil](/molmil-images/mine/2xlp) | Joint-functions of protein residues and NADP(H) in oxygen-activation by flavin-containing monooxygenase: Asn78Ser mutant | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Orru, R, Fraaije, M.W, Mattevi, A. | 登録日 | 2010-07-21 | 公開日 | 2010-09-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase. J. Biol. Chem., 285, 2010
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7K3V
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![BU of 7k3v by Molmil](/molmil-images/mine/7k3v) | Apoferritin structure at 1.34 angstrom resolution determined from a 300 kV Titan Krios G3i electron microscope with K3 detector | 分子名称: | Ferritin heavy chain, SODIUM ION, ZINC ION | 著者 | Zhang, K, Pintilie, G, Li, S, Schmid, M, Chiu, W. | 登録日 | 2020-09-14 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (1.34 Å) | 主引用文献 | Resolving individual atoms of protein complex by cryo-electron microscopy. Cell Res., 30, 2020
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7F5W
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![BU of 7f5w by Molmil](/molmil-images/mine/7f5w) | |
7TQA
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![BU of 7tqa by Molmil](/molmil-images/mine/7tqa) | |
7C23
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![BU of 7c23 by Molmil](/molmil-images/mine/7c23) | Crystal structure of CrmE10, a SGNH-hydrolase family esterase | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Li, Z, Li, J. | 登録日 | 2020-05-07 | 公開日 | 2020-05-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels, 13, 2020
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3J5Q
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![BU of 3j5q by Molmil](/molmil-images/mine/3j5q) | Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy | 分子名称: | Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 | 著者 | Liao, M, Cao, E, Julius, D, Cheng, Y. | 登録日 | 2013-10-28 | 公開日 | 2013-12-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | TRPV1 structures in distinct conformations reveal activation mechanisms. Nature, 504, 2013
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5M8U
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![BU of 5m8u by Molmil](/molmil-images/mine/5m8u) | PCE reductive dehalogenase from S. multivorans in complex with 4-bromophenol | 分子名称: | 4-BROMOPHENOL, BENZAMIDINE, GLYCEROL, ... | 著者 | Kunze, C, Bommer, M, Hagen, W.R, Uksa, M, Dobbek, H, Schubert, T, Diekert, G. | 登録日 | 2016-10-30 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer. Nat Commun, 8, 2017
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3J6F
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![BU of 3j6f by Molmil](/molmil-images/mine/3j6f) | Minimized average structure of GDP-bound dynamic microtubules | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | 登録日 | 2014-02-19 | 公開日 | 2014-06-04 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis. Cell(Cambridge,Mass.), 157, 2014
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2XEY
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![BU of 2xey by Molmil](/molmil-images/mine/2xey) | Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors | 分子名称: | 3-(1H-INDOL-3-YL)-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE, SERINE/THREONINE-PROTEIN KINASE CHK1 | 著者 | Matthews, T.P, McHardy, T, Klair, S, Boxall, K, Fisher, M, Cherry, M, Allen, C.E, Addison, G.J, Ellard, J, Aherne, G.W, Westwood, I.M, van Montfort, R, Garrett, M.D, Reader, J.C, Collins, I. | 登録日 | 2010-05-19 | 公開日 | 2010-06-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases. Bioorg.Med.Chem.Lett., 20, 2010
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7EQ7
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![BU of 7eq7 by Molmil](/molmil-images/mine/7eq7) | |
5MA7
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![BU of 5ma7 by Molmil](/molmil-images/mine/5ma7) | Structure of thermolysin in complex with inhibitor (JC306). | 分子名称: | (2~{S})-2-[[(2~{S})-3-azanyl-2-[[oxidanyl(phenylmethoxycarbonylaminomethyl)phosphoryl]amino]propanoyl]amino]-4-methyl-pentanoic acid, CALCIUM ION, DIMETHYL SULFOXIDE, ... | 著者 | Krimmer, S.G, Cramer, J, Heine, A, Klebe, G. | 登録日 | 2016-11-03 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1' Pocket of Thermolysin. J. Am. Chem. Soc., 139, 2017
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5M8Z
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![BU of 5m8z by Molmil](/molmil-images/mine/5m8z) | PCE reductive dehalogenase from S. multivorans in complex with 2,3-difluorophenol | 分子名称: | 2,3-bis(fluoranyl)phenol, BENZAMIDINE, GLYCEROL, ... | 著者 | Kunze, C, Bommer, M, Hagen, W.R, Uksa, M, Dobbek, H, Schubert, T, Diekert, G. | 登録日 | 2016-10-30 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.659 Å) | 主引用文献 | Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer. Nat Commun, 8, 2017
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7TT0
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![BU of 7tt0 by Molmil](/molmil-images/mine/7tt0) | BamABCDE bound to substrate EspP class 2 | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | 著者 | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | 登録日 | 2022-01-31 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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7BTW
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![BU of 7btw by Molmil](/molmil-images/mine/7btw) | The mitochondrial SAM complex from S.cere | 分子名称: | Mitochondrial outer membrane beta-barrel protein, SAM37 isoform 1, Sorting assembly machinery 35 kDa subunit | 著者 | Takeda, H, Tsutsumi, A, Nishizawa, T, Nureki, O, Kikkawa, M, Endo, T. | 登録日 | 2020-04-03 | 公開日 | 2021-01-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mitochondrial sorting and assembly machinery operates by beta-barrel switching. Nature, 590, 2021
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2XBS
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![BU of 2xbs by Molmil](/molmil-images/mine/2xbs) | Raman crystallography of Hen White Egg Lysozyme - High X-ray dose (16 MGy) | 分子名称: | CHLORIDE ION, LYSOZYME C | 著者 | Carpentier, P, Royant, A, Weik, M, Bourgeois, D. | 登録日 | 2010-04-14 | 公開日 | 2010-11-24 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Raman Assisted Crystallography Reveals a Mechanism of X-Ray Induced Reversible Disulfide Radical Formation Structure, 18, 2010
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2IVZ
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![BU of 2ivz by Molmil](/molmil-images/mine/2ivz) | Structure of TolB in complex with a peptide of the colicin E9 T- domain | 分子名称: | CALCIUM ION, COLICIN-E9, PROTEIN TOLB | 著者 | Loftus, S.R, Walker, D, Mate, M.J, Bonsor, D.A, James, R, Moore, G.R, Kleanthous, C. | 登録日 | 2006-06-23 | 公開日 | 2006-08-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Competitive Recruitment of the Periplasmic Translocation Portal Tolb by a Natively Disordered Domain of Colicin E9 Proc.Natl.Acad.Sci.USA, 103, 2006
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5MAR
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![BU of 5mar by Molmil](/molmil-images/mine/5mar) | Structure of human SIRT2 in complex with 1,2,4-Oxadiazole inhibitor and ADP ribose. | 分子名称: | 1,2-ETHANEDIOL, 3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]propan-1-ol, ACETATE ION, ... | 著者 | Moniot, S, Steegborn, C. | 登録日 | 2016-11-04 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity. J. Med. Chem., 60, 2017
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7TT5
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![BU of 7tt5 by Molmil](/molmil-images/mine/7tt5) | BamABCDE bound to substrate EspP in the open-sheet EspP state | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Serine protease EspP chimera, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamC, ... | 著者 | Doyle, M.T, Jimah, J.R, Dowdy, T, Ohlemacher, S.I, Larion, M, Hinshaw, J.E, Bernstein, H.D. | 登録日 | 2022-01-31 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding. Cell, 185, 2022
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7Q8O
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![BU of 7q8o by Molmil](/molmil-images/mine/7q8o) | Peptide LLSGKE in complex with human cathepsin V C25S mutant | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cathepsin L2, ... | 著者 | Loboda, J, Sosnowski, P, Tusar, L, Vidmar, R, Vizovisek, M, Horvat, J, Kosec, G, Impens, F, Demol, H, Turk, B, Gevaert, K, Turk, D. | 登録日 | 2021-11-11 | 公開日 | 2022-11-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. Commun Biol, 6, 2023
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2XO6
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![BU of 2xo6 by Molmil](/molmil-images/mine/2xo6) | DEINOCOCCUS RADIODURANS ISDRA2 TRANSPOSASE Y132F MUTANT COMPLEXED WITH LEFT END RECOGNITION AND CLEAVAGE SITE | 分子名称: | 5'-D(*TP*TP*GP*AP*TP*G)-3', ACETATE ION, CADMIUM ION, ... | 著者 | Hickman, A.B, James, J.A, Barabas, O, Pasternak, C, Ton-Hoang, B, Chandler, M, Sommer, S, Dyda, F. | 登録日 | 2010-08-09 | 公開日 | 2010-10-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | DNA Recognition and the Precleavage State During Single-Stranded DNA Transposition in D. Radiodurans. Embo J., 29, 2010
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7JY8
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2XP7
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![BU of 2xp7 by Molmil](/molmil-images/mine/2xp7) | DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION | 分子名称: | 2-PHENYL-1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID, DODECAETHYLENE GLYCOL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 | 著者 | Potter, A, Oldfield, V, Nunns, C, Fromont, C, Ray, S, Northfield, C.J, Bryant, C.J, Scrace, S.F, Robinson, D, Matossova, N, Baker, L, Dokurno, P, Surgenor, A.E, Davis, B.E, Richardson, C.M, Murray, J.B, Moore, J.D. | 登録日 | 2010-08-25 | 公開日 | 2011-01-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. Bioorg.Med.Chem.Lett., 20, 2010
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