3GZ3
 
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2V28
 | | Apo structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea 34H | | 分子名称: | PHENYLALANINE-4-HYDROXYLASE, SULFATE ION | | 著者 | Leiros, H.-K.S, Pey, A.L, Innselset, M, Moe, E, Leiros, I, Steen, I.H, Martinez, A. | | 登録日 | 2007-06-04 | | 公開日 | 2007-06-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of Phenylalanine Hydroxylase from Colwellia Psychrerythraea 34H, a Monomeric Cold Active Enzyme with Local Flexibility Around the Active Site and High Overall Stability.
J.Biol.Chem., 282, 2007
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2JG7
 | | Crystal structure of Seabream Antiquitin and Elucidation of its substrate specificity | | 分子名称: | ANTIQUITIN, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Tang, W.K, Wong, K.B, Cha, S.S, Lee, H.S, Cheng, C.H.K, Fong, W.P. | | 登録日 | 2007-02-09 | | 公開日 | 2008-05-13 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | The Crystal Structure of Seabream Antiquitin Reveals the Structural Basis of its Substrate Specificity.
FEBS Lett., 582, 2008
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6KMA
 | | Crystal structure of SucA with glycolaldehyde-1-13C from Vibrio vulnificus | | 分子名称: | 2-oxidanylethanal, CALCIUM ION, HEXAETHYLENE GLYCOL, ... | | 著者 | Seo, P.W, Kim, J.S. | | 登録日 | 2019-07-31 | | 公開日 | 2020-08-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.282 Å) | | 主引用文献 | Understanding the molecular properties of the E1 subunit (SucA) of alpha-ketoglutarate dehydrogenase complex from Vibrio vulnificus for the enantioselective ligation of acetaldehydes into (R)-acetoin.
Catalysis Science And Technology, 2020
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6JTL
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4PVI
 | | Crystal structure of GH62 hydrolase in complex with xylotriose | | 分子名称: | GH62 hydrolase, PHOSPHATE ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose | | 著者 | Nocek, B, Kaur, A.P, Xu, X, Cui, H, Savchenko, A. | | 登録日 | 2014-03-17 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Crystal structure of GH62 hydrolase in complex with xylotriose
TO BE PUBLISHED
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6JU1
 | | p-Hydroxybenzoate hydroxylase Y385F mutant complexed with 3,4-dihydroxybenzoate | | 分子名称: | 3,4-DIHYDROXYBENZOIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 4-hydroxybenzoate 3-monooxygenase, ... | | 著者 | Yato, M, Arakawa, T, Yamada, C, Fushinobu, S. | | 登録日 | 2019-04-12 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Understanding the Molecular Mechanism Underlying the High Catalytic Activity ofp-Hydroxybenzoate Hydroxylase Mutants for Producing Gallic Acid.
Biochemistry, 58, 2019
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6JVO
 | | Crystal structure of human MTH1 in complex with compound MI1022 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine | | 著者 | Peng, C, Li, Y.H, Cheng, Y.S. | | 登録日 | 2019-04-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
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3GG2
 | | Crystal structure of UDP-glucose 6-dehydrogenase from Porphyromonas gingivalis bound to product UDP-glucuronate | | 分子名称: | Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family, URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID | | 著者 | Bonanno, J.B, Freeman, J, Bain, K.T, Chang, S, Sampathkumar, P, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-02-27 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of UDP-glucose 6-dehydrogenase from Porphyromonas gingivalis bound to product UDP-glucuronate
To be Published
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7XQN
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6JVG
 | | Crystal structure of human MTH1 in complex with compound MI0639 | | 分子名称: | 5-ethyl-4-methyl-6-(morpholin-4-yl)pyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase | | 著者 | Peng, C, Cheng, Y.S. | | 登録日 | 2019-04-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.844 Å) | | 主引用文献 | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
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2JIJ
 | | Crystal structure of the apo form of Chlamydomonas reinhardtii prolyl- 4 hydroxylase type I | | 分子名称: | CHLORIDE ION, PROLYL-4 HYDROXYLASE | | 著者 | Koski, M.K, Hieta, R, Bollner, C, Kivirikko, K.I, Myllyharju, J, Wierenga, R.K. | | 登録日 | 2007-06-28 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity.
J.Biol.Chem., 282, 2007
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3GHH
 | | Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ecto-NAD+ glycohydrolase (CD38 molecule), SULFATE ION, ... | | 著者 | Egea, P.F, Muller-Steffner, H, Stroud, R.M, Oppenheimer, N.J, Kellenberger, E, Schuber, F. | | 登録日 | 2009-03-03 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
Plos One, 7, 2012
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2V8I
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6JVQ
 | | Crystal structure of human MTH1 in complex with compound MI1025 | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-6-morpholin-4-yl-pyrimidine-2,4-diamine | | 著者 | Peng, C, Li, Y.H, Cheng, Y.S. | | 登録日 | 2019-04-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | | 主引用文献 | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
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6CIW
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4Q0R
 | | The catalytic core of Rad2 (complex I) | | 分子名称: | DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3'), DNA repair protein RAD2 | | 著者 | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | | 登録日 | 2014-04-02 | | 公開日 | 2014-08-27 | | 最終更新日 | 2017-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
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4Q0Z
 | | The catalytic core of Rad2 in complex with DNA substrate (complex III) | | 分子名称: | CALCIUM ION, DNA (5'-D(*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*T)-3'), ... | | 著者 | Mietus, M, Nowak, E, Jaciuk, M, Kustosz, P, Nowotny, M. | | 登録日 | 2014-04-02 | | 公開日 | 2014-08-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | | 主引用文献 | Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
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7YI7
 | | Crystal structure of Human HPSE1 in complex with inhibitor | | 分子名称: | (5~{S},6~{R},7~{S},8~{S})-6,7,8-tris(oxidanyl)-2-[2-[4-(trifluoromethyl)phenyl]ethyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid, Heparanase 50 kDa subunit, Heparanase 8 kDa subunit | | 著者 | Mima, M, Fujimoto, N, Imai, Y. | | 登録日 | 2022-07-15 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor.
Bioorg.Med.Chem.Lett., 79, 2022
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6CIO
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7YJC
 | | Crystal structure of Human HPSE1 in complex with inhibitor | | 分子名称: | (5~{S},6~{R},7~{S},8~{S})-6,7,8-tris(oxidanyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid, Heparanase 50 kDa subunit, Heparanase 8 kDa subunit | | 著者 | Mima, M, Fujimoto, N, Imai, Y. | | 登録日 | 2022-07-19 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor.
Bioorg.Med.Chem.Lett., 79, 2022
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6CJF
 | | Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43 | | 分子名称: | 2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid, 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Petrunak, E.M, Stuckey, J.A. | | 登録日 | 2018-02-26 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
J. Med. Chem., 61, 2018
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7XQM
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4PZ2
 | | Structure of Zm ALDH2-6 (RF2F) in complex with NAD | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Morera, S, Vigouroux, A, Kopecny, D. | | 登録日 | 2014-03-28 | | 公開日 | 2015-03-18 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Role and structural characterization of plant aldehyde dehydrogenases from family 2 and family 7.
Biochem.J., 468, 2015
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4Q3M
 | | Crystal structure of MGS-M4, an aldo-keto reductase enzyme from a Medee basin deep-sea metagenome library | | 分子名称: | MGS-M4, SODIUM ION, SULFATE ION | | 著者 | Stogios, P.J, Xu, X, Cui, H, Alcaide, M, Ferrer, M, Savchenko, A. | | 登録日 | 2014-04-11 | | 公開日 | 2015-02-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | | 主引用文献 | Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats.
Environ Microbiol, 17, 2015
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