PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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6BR3	Structure of RORgt in complex with a novel inverse agonist TAK-828. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Nuclear receptor ROR-gamma, {cis-3-[(5R)-5-[(7-fluoro-1,1-dimethyl-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carbonyl]cyclobutyl}acetic acid 著者 Skene, R.J, Hoffman, I. 登録日 2017-11-29 公開日 2018-03-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor gamma t Inverse Agonist. J. Med. Chem., 61, 2018
6BRG	The SAM domain of mouse SAMHD1 is critical for its activation and regulation 分子名称: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, MAGNESIUM ION 著者 Buzovetsky, O, Tang, C, Knecht, K.M, Antonucci, J.M, Wu, L, Ji, X, Xiong, Y. 登録日 2017-11-30 公開日 2018-02-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat Commun, 9, 2018
3INA	Crystal structure of heparin lyase I H151A mutant complexed with a dodecasaccharide heparin 分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, CALCIUM ION, Heparin lyase I 著者 Han, Y.H, Ryu, K.S, Kim, H.Y, Jeon, Y.H. 登録日 2009-08-12 公開日 2009-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural snapshots of heparin depolymerization by heparin lyase I J.Biol.Chem., 284, 2009
3I2D	Crystal Structure of S. Cerevisiae SUMO E3 Ligase SIZ1 分子名称: E3 SUMO-protein ligase SIZ1, ZINC ION 著者 Lima, C.D, Yunus, A.A. 登録日 2009-06-29 公開日 2009-09-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. Mol.Cell, 35, 2009
3V2P	COMPcc in complex with fatty acids 分子名称: Cartilage Oligomerization matrix protein (coiled-coil domain), STEARIC ACID 著者 Stetefeld, J. 登録日 2011-12-12 公開日 2013-01-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.873 Å) 主引用文献 The pentameric channel of COMPcc in complex with different fatty acids. Plos One, 7, 2012
3TII	Tubulin tyrosine ligase 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ttl protein 著者 Roll-Mecak, A, Szyk, A, Deaconescu, A, Piszczek, G. 登録日 2011-08-20 公開日 2011-10-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin. Nat.Struct.Mol.Biol., 18, 2011
1N5O	Structural consequences of a cancer-causing BRCA1-BRCT missense mutation 分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION 著者 Williams, R.S, Glover, J.N.M. 登録日 2002-11-06 公開日 2002-12-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural consequences of a cancer-causing BRCA1-BRCT missense mutation J.Biol.Chem., 278, 2003
1MZ8	CRYSTAL STRUCTURES OF THE NUCLEASE DOMAIN OF COLE7/IM7 IN COMPLEX WITH A PHOSPHATE ION AND A ZINC ION 分子名称: Colicin E7, Colicin E7 immunity protein, PHOSPHATE ION, ... 著者 Sui, M.J, Tsai, L.C, Hsia, K.C, Doudeva, L.G, Ku, W.Y, Han, G.W, Yuan, H.S. 登録日 2002-10-07 公開日 2002-12-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Metal ions and phosphate binding in the H-N-H motif: crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ions PROTEIN SCI., 11, 2002
3FJ9	Crystal structure of F85W mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. J.Mol.Biol., 393, 2009
3U6U	Crystal structure of the putative acetylglutamate kinase from thermus thermophilus 分子名称: Putative acetylglutamate kinase, SULFATE ION 著者 Karthe, P, Kumarevel, T.S, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-10-13 公開日 2011-11-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 The structure of first dimeric archaeal N-acetyl glutamate kinase reveals an intermediate conformation of the enzyme in the catalytic cycle To be Published
3W1S	Crystal structure of Saccharomyces cerevisiae Atg12-Atg5 conjugate bound to the N-terminal domain of Atg16 分子名称: Autophagy protein 16, Autophagy protein 5, Ubiquitin-like protein ATG12 著者 Noda, N.N, Fujioka, Y, Hanada, T, Ohsumi, Y, Inagaki, F. 登録日 2012-11-20 公開日 2012-12-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation Embo Rep., 14, 2013
6B31	Structure of RORgt in complex with a novel inverse agonist 2 分子名称: (3S)-N~1~-(3-chloro-4-cyanophenyl)-N~5~-(1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-methylpentanediamide, Nuclear receptor ROR-gamma 著者 Skene, R.J, Hoffman, I. 登録日 2017-09-20 公開日 2018-08-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 Identification of novel quinazolinedione derivatives as ROR gamma t inverse agonist. Bioorg. Med. Chem., 26, 2018
3F1J	Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals RNA binding properties 分子名称: CYTIDINE-5'-MONOPHOSPHATE, Matrix protein, SULFATE ION 著者 Neumann, P, Lieber, D, Meyer, S, Dautel, P, Kerth, A, Kraus, I, Garten, W, Stubbs, M.T. 登録日 2008-10-28 公開日 2009-02-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties Proc.Natl.Acad.Sci.USA, 106, 2009
3VH1	Crystal structure of Saccharomyces cerevisiae Atg7 (1-595) 分子名称: Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION 著者 Noda, N.N, Satoo, K, Inagaki, F. 登録日 2011-08-23 公開日 2011-09-21 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol.Cell, 44, 2011
6CVH	Identification and biological evaluation of thiazole-based inverse agonists of RORgt 分子名称: Nuclear receptor ROR-gamma, trans-3-({4-(cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-{[(2R)-1,1,1-trifluoropropan-2-yl]carbamoyl}phenyl]-1,3-thiazole-2-carbonyl}amino)cyclobutane-1-carboxylic acid 著者 Spurlino, J, Milligan, C. 登録日 2018-03-28 公開日 2018-04-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Identification and biological evaluation of thiazole-based inverse agonists of ROR gamma t. Bioorg. Med. Chem. Lett., 28, 2018
3VH2	Crystal structure of Saccharomyces cerevisiae Atg7 (1-613) 分子名称: Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION 著者 Noda, N.N, Satoo, K, Inagaki, F. 登録日 2011-08-23 公開日 2011-09-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol.Cell, 44, 2011
3VX6	Crystal structure of Kluyveromyces marxianus Atg7NTD 分子名称: E1 著者 Yamaguchi, M, Matoba, K, Sawada, R, Fujioka, Y, Nakatogawa, H, Yamamoto, H, Kobashigawa, Y, Hoshida, H, Akada, R, Ohsumi, Y, Noda, N.N, Inagaki, F. 登録日 2012-09-11 公開日 2012-11-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Nat.Struct.Mol.Biol., 19, 2012
3VXW	Crystal structure of Saccharomyces cerevisiae Atg8 complexed with Atg32 AIM 分子名称: Autophagy-related protein 8, Peptide from Autophagy-related protein 32, SULFATE ION 著者 Noda, N.N, Inagaki, F. 登録日 2012-09-21 公開日 2012-10-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy J.Biol.Chem., 287, 2012
3VQI	Crystal structure of Kluyveromyces marxianus Atg5 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Atg5, SULFATE ION 著者 Yamaguchi, M, Noda, N.N, Yamamoto, H, Shima, T, Kumeta, H, Kobashigawa, Y, Akada, R, Ohsumi, Y, Inagaki, F. 登録日 2012-03-24 公開日 2012-08-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into atg10-mediated formation of the autophagy-essential atg12-atg5 conjugate Structure, 20, 2012
3II4	Structure of mycobacterial lipoamide dehydrogenase bound to a triazaspirodimethoxybenzoyl inhibitor 分子名称: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N-[2-(2,4-dichlorophenyl)ethyl]-2-{8-[(2,4-dimethoxyphenyl)carbonyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl}acetamide 著者 Lima, C.D. 登録日 2009-07-31 公開日 2010-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry, 49, 2010
3TIG	Tubulin tyrosine ligase 分子名称: MAGNESIUM ION, Ttl protein 著者 Roll-Mecak, A, Szyk, A, Deaconescu, A, Piszczek, G. 登録日 2011-08-20 公開日 2011-10-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin. Nat.Struct.Mol.Biol., 18, 2011
6CBD	Crystal Structure of Human Argonaute2 Bound to Three Tryptophans 分子名称: Guide RNA, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... 著者 Sheu-Gruttadauria, J, MacRae, I.J. 登録日 2018-02-02 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Phase Transitions in the Assembly and Function of Human miRISC. Cell, 173, 2018
4PKK	Crystal structure of Macrophage Migration inhibitory factor in complex with furan-2-ylmethyl)imino methanethiol 分子名称: (Z)-[(furan-2-ylmethyl)imino]methanethiol, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Pantouris, G, Lolis, E. 登録日 2014-05-14 公開日 2016-05-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal structure of Macrophage Migration inhibitory factor with a covalent inhibitor To Be Published
3FKB	Structure of NDPK H122G and tenofovir-diphosphate 分子名称: 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... 著者 Morera, S, Chen, Y.X. 登録日 2008-12-16 公開日 2009-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives Nucleosides Nucleotides Nucleic Acids, 28, 2009
3F11	Structure of futa1 with iron(III) 分子名称: 1,2-ETHANEDIOL, FE (III) ION, Iron transport protein, ... 著者 Koropatkin, N.M, Randich, A.M, Bhattachryya-Pakrasi, M, Pakrasi, H.B, Smith, T.J. 登録日 2008-10-27 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structure of the iron-binding protein, FutA1, from Synechocystis 6803 J.Biol.Chem., 282, 2007

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