PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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8AOG	Non-specific covalent inhibitor(17) of ERK2 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Cleasby, A. 登録日 2022-08-08 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 X-RAY DIFFRACTION (1.603 Å) 主引用文献 X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOI	Specific covalent inhibitor(19) of ERK2 分子名称: 1,2-ETHANEDIOL, 1-(2,3-dihydropyrido[2,3-b][1,4]oxazin-1-yl)propan-1-one, Mitogen-activated protein kinase 1, ... 著者 Cleasby, A. 登録日 2022-08-08 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO2	Specific covalent inhibitor (3) of ERK2 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Cleasby, A. 登録日 2022-08-08 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 X-RAY DIFFRACTION (1.796 Å) 主引用文献 X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOD	Specific covalent inhibitor(14) of ERK2 分子名称: 1,2-ETHANEDIOL, 1-(3-oxidanyl-2~{H}-quinoxalin-1-yl)propan-1-one, 4-prop-2-enoyl-1,3-dihydroquinoxalin-2-one, ... 著者 Cleasby, A. 登録日 2022-08-08 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO7	Specific covalent inhibitor (8) of ERK2 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Cleasby, A. 登録日 2022-08-08 公開日 2022-09-28 最終更新日 2022-10-05 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOE	Specific covalent inhibitor(15) of ERK2 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Cleasby, A. 登録日 2022-08-08 公開日 2022-09-28 最終更新日 2023-05-24 実験手法 X-RAY DIFFRACTION (1.687 Å) 主引用文献 X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
6DGX	Crystal structure of HIV-1 Protease NL4-3 WT in complex with darunavir 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6DH6	Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with darunavir 分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6DGY	Crystal structure of HIV-1 Protease NL4-3 WT in complex with UMass1 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.954 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6DH7	Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with UMass1 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6DH2	Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with UMass6 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6QGI	Crystal structure of VP5 from Haloarchaeal pleomorphic virus 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, VP5 著者 El Omari, K, Walter, T.S, Harlos, K, Grimes, J.M, Stuart, D.I, Roine, E. 登録日 2019-01-11 公開日 2019-02-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nat Commun, 10, 2019
6QGL	Crystal structure of VP5 from Haloarchaeal pleomorphic virus 6 分子名称: BROMIDE ION, VP5 著者 El Omari, K, Walter, T.S, Harlos, K, Grimes, J.M, Stuart, D.I, Roine, E. 登録日 2019-01-11 公開日 2019-02-27 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nat Commun, 10, 2019
4Z87	Structure of the IMP dehydrogenase from Ashbya gossypii bound to GDP 分子名称: ACETATE ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Buey, R.M, de Pereda, J.M, Revuelta, J.L. 登録日 2015-04-08 公開日 2015-11-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases. Nat Commun, 6, 2015
8SPO	Tetramerized activation of MapSPARTA bound with NAD+ 分子名称: MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Piwi domain-containing protein, ... 著者 Shen, Z.F, Yang, X.Y, Fu, T.M. 登録日 2023-05-03 公開日 2023-08-23 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
8SP0	Symmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid 分子名称: MAGNESIUM ION, TIR-APAZ, guide RNA, ... 著者 Shen, Z.F, Yang, X.Y, Fu, T.M. 登録日 2023-05-01 公開日 2023-08-23 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
8FDL	Human Hemoglobin with Nitrosochloramphenicol 分子名称: GLYCEROL, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Powell, S.M, Richter-Addo, G.B, Thomas, L.M. 登録日 2022-12-03 公開日 2023-07-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin. J.Inorg.Biochem., 246, 2023
8FDK	Phenylhydroxylamine in Reaction with Human Hemoglobin 分子名称: GLYCEROL, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Powell, S.M, Thomas, L.M, Richter-Addo, G.B. 登録日 2022-12-03 公開日 2023-07-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin. J.Inorg.Biochem., 246, 2023
8FDN	Human Hemoglobin with N-tertbutylhydroxylamine 分子名称: GLYCEROL, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Powell, S.M, Richter-Addo, G.B, Thomas, L.M. 登録日 2022-12-03 公開日 2023-07-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin. J.Inorg.Biochem., 246, 2023
2MVN	Solution structure of eEF1Bdelta CAR domain in TCTP-bound state 分子名称: Elongation factor 1-delta 著者 Wu, H, Feng, Y. 登録日 2014-10-09 公開日 2015-02-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Evolutionarily Conserved Binding of Translationally Controlled Tumor Protein to Eukaryotic Elongation Factor 1B. J.Biol.Chem., 290, 2015
3Q9C	Crystal Structure of H159A APAH complexed with N8-acetylspermidine 分子名称: Acetylpolyamine amidohydrolase, N-{4-[(3-aminopropyl)amino]butyl}acetamide, POTASSIUM ION, ... 著者 Lombardi, P.M, Christianson, D.W. 登録日 2011-01-07 公開日 2011-03-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases . Biochemistry, 50, 2011
8FDM	Human Hemoglobin in Complex with Nitrosomethane 分子名称: GLYCEROL, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Powell, S.M, Richter-Addo, G.B, Thomas, L.M. 登録日 2022-12-03 公開日 2023-07-12 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Crystal structural investigations of heme protein derivatives resulting from reactions of aryl- and alkylhydroxylamines with human hemoglobin. J.Inorg.Biochem., 246, 2023
8HSB	Cryo-EM Structure of CdnG-E2 complex from Serratia marcescens (UltrAuFoil) 分子名称: CdnG, Type VI secretion protein 著者 Xiao, J, Wang, L. 登録日 2022-12-18 公開日 2024-05-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway. Nat Microbiol, 9, 2024
4Z0G	Structure of the IMPDH from Ashbya gossypii bound to GMP 分子名称: GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, ... 著者 Buey, R.M, de Pereda, J.M, Revuelta, J.L. 登録日 2015-03-26 公開日 2015-11-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases. Nat Commun, 6, 2015
8OHS	Core-binding domain of fungal E3-binding domain bound to the native pyruvate dehydrogenase E2 core 分子名称: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Pyruvate dehydrogenase X component 著者 Forsberg, B.O. 登録日 2023-03-21 公開日 2023-04-26 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 The structure and evolutionary diversity of the fungal E3-binding protein. Commun Biol, 6, 2023

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