6DGX
Crystal structure of HIV-1 Protease NL4-3 WT in complex with darunavir
Summary for 6DGX
Entry DOI | 10.2210/pdb6dgx/pdb |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hiv, protease, nl4-3, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22307.39 |
Authors | Lockbaum, G.J.,Schiffer, C.A. (deposition date: 2018-05-18, release date: 2018-12-26, Last modification date: 2023-10-11) |
Primary citation | Lockbaum, G.J.,Leidner, F.,Rusere, L.N.,Henes, M.,Kosovrasti, K.,Nachum, G.S.,Nalivaika, E.A.,Ali, A.,Yilmaz, N.K.,Schiffer, C.A. Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5:316-325, 2019 Cited by PubMed: 30543749DOI: 10.1021/acsinfecdis.8b00336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
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