6DH6

Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with darunavir

Summary for 6DH6

Entry DOI	10.2210/pdb6dh6/pdb
Descriptor	Protease, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (4 entities in total)
Functional Keywords	hiv, protease, nl4-3, drug resistance, protease inhibitor, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22471.47
Authors	Lockbaum, G.J.,Schiffer, C.A. (deposition date: 2018-05-18, release date: 2018-12-26, Last modification date: 2023-10-11)
Primary citation	Lockbaum, G.J.,Leidner, F.,Rusere, L.N.,Henes, M.,Kosovrasti, K.,Nachum, G.S.,Nalivaika, E.A.,Ali, A.,Yilmaz, N.K.,Schiffer, C.A. Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5:316-325, 2019 Cited by PubMed: 30543749 DOI: 10.1021/acsinfecdis.8b00336 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation