6DH6
Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with darunavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Protease | polymer | 99 | 10817.8 | 2 | UniProt (Q8ULI3) UniProt (by SIFTS) (Q7ZCR0) | Human immunodeficiency virus 1 | |
| 2 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | F (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 4 | G, H (B, A) | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: Q8ULI3)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Val 50 | Ile 50 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21635.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 835.9 | |
| All* | Total formula weight | 22471.5 |
