2ZG0
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![BU of 2zg0 by Molmil](/molmil-images/mine/2zg0) | Exploring thrombin S3 pocket | 分子名称: | (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide, Hirudin, SODIUM ION, ... | 著者 | Brandt, T, Baum, B, Heine, A, Klebe, G. | 登録日 | 2008-01-16 | 公開日 | 2009-01-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Exploring thrombin S3 pocket To be Published
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3II9
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![BU of 3ii9 by Molmil](/molmil-images/mine/3ii9) | Crystal structure of glutaryl-coa dehydrogenase from Burkholderia pseudomallei at 1.73 Angstrom | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Glutaryl-CoA dehydrogenase, ... | 著者 | Ismagilov, R.F, Li, L, Du, W.B, Staker, B, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2009-07-31 | 公開日 | 2009-12-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments. J.Am.Chem.Soc., 132, 2010
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7PVN
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![BU of 7pvn by Molmil](/molmil-images/mine/7pvn) | Crystal Structure of Human UBA6 in Complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... | 著者 | Truongvan, N, Li, S, Schindelin, H. | 登録日 | 2021-10-05 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structures of UBA6 explain its dual specificity for ubiquitin and FAT10. Nat Commun, 13, 2022
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2ZYF
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![BU of 2zyf by Molmil](/molmil-images/mine/2zyf) | Crystal structure of homocitrate synthase from Thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate | 分子名称: | 2-OXOGLUTARIC ACID, Homocitrate synthase, MAGNESIUM ION | 著者 | Okada, T, Tomita, T, Kuzuyama, T, Nishiyama, M. | 登録日 | 2009-01-20 | 公開日 | 2009-12-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Mechanism of substrate recognition and insight into feedback inhibition of homocitrate synthase from thermus thermophilus J.Biol.Chem., 2009
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8PAR
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![BU of 8par by Molmil](/molmil-images/mine/8par) | Crystal structure of human MAP4K1 with an inhibitor, BAY-405 | 分子名称: | GLYCEROL, Mitogen-activated protein kinase kinase kinase kinase 1, ~{N}-[3,5-bis(fluoranyl)-4-[[3-[1-(trifluoromethyl)cyclopropyl]-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-2,9-dioxa-4-azaspiro[5.5]undec-3-en-3-amine | 著者 | Schaefer, M. | 登録日 | 2023-06-08 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405 To Be Published
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7PHE
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![BU of 7phe by Molmil](/molmil-images/mine/7phe) | Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK | 分子名称: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | 著者 | Dinis, P, MetsaKetela, M. | 登録日 | 2021-08-17 | 公開日 | 2022-09-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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2ZYS
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![BU of 2zys by Molmil](/molmil-images/mine/2zys) | A. Fulgidus lipase with fatty acid fragment and chloride | 分子名称: | CHLORIDE ION, Lipase, putative, ... | 著者 | Chen, C.K, Ko, T.P, Guo, R.T, Wang, A.H. | 登録日 | 2009-01-29 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the alkalohyperthermophilic Archaeoglobus fulgidus lipase contains a unique C-terminal domain essential for long-chain substrate binding. J.Mol.Biol., 390, 2009
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7ATL
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![BU of 7atl by Molmil](/molmil-images/mine/7atl) | EstCE1, a hydrolase with promiscuous acyltransferase activity | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Esterase, ... | 著者 | Palm, G.J, Lammers, M, Berndt, L. | 登録日 | 2020-10-30 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.478 Å) | 主引用文献 | Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases. Angew.Chem.Int.Ed.Engl., 60, 2021
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3ISJ
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![BU of 3isj by Molmil](/molmil-images/mine/3isj) | Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide | 分子名称: | 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide, ETHANOL, GLYCEROL, ... | 著者 | Silvestre, H.L, Hung, A.W, Wen, S, Ciulli, A, Blundell, T.L, Abell, C. | 登録日 | 2009-08-26 | 公開日 | 2009-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase Angew.Chem.Int.Ed.Engl., 48, 2009
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7AV7
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![BU of 7av7 by Molmil](/molmil-images/mine/7av7) | Crystal structure of S-nitrosylated nitrosoglutathione reductase(GSNOR)from Chlamydomonas reinhardtii, in complex with NAD+ | 分子名称: | CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-(hydroxymethyl)glutathione dehydrogenase, ... | 著者 | Fermani, S, Zaffagnini, M, Falini, G, Lemaire, S.D. | 登録日 | 2020-11-04 | 公開日 | 2020-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural and functional insights into nitrosoglutathione reductase from Chlamydomonas reinhardtii. Redox Biol, 38, 2020
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7PHT
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7AX8
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7DXG
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![BU of 7dxg by Molmil](/molmil-images/mine/7dxg) | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | 著者 | Chen, L, Guo, W. | 登録日 | 2021-01-18 | 公開日 | 2022-02-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7K7U
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7AXE
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![BU of 7axe by Molmil](/molmil-images/mine/7axe) | Crystal structure of the hPXR-LBD in complex with oxadiazon | 分子名称: | GLYCEROL, ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, ... | 著者 | Harrus, D, Delfosse, V, Bourguet, W. | 登録日 | 2020-11-09 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DYX
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![BU of 7dyx by Molmil](/molmil-images/mine/7dyx) | Human JMJD5 in complex with MN and 5-((2-cyclopropylbenzyl)amino)pyridine-2,4-dicarboxylic acid. | 分子名称: | 5-((2-cyclopropylbenzyl)amino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2021-01-23 | 公開日 | 2022-02-02 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
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7SN4
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3ITE
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![BU of 3ite by Molmil](/molmil-images/mine/3ite) | The third adenylation domain of the fungal SidN non-ribosomal peptide synthetase | 分子名称: | CHLORIDE ION, SULFATE ION, SidN siderophore synthetase | 著者 | Lee, T.V, Lott, J.S, Johnson, R.D, Johnson, L.J, Arcus, V.L. | 登録日 | 2009-08-28 | 公開日 | 2009-11-17 | 最終更新日 | 2014-02-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis J.Biol.Chem., 285, 2010
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7B0J
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![BU of 7b0j by Molmil](/molmil-images/mine/7b0j) | TRPC4 in LMNG detergent | 分子名称: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CALCIUM ION, Transient receptor potential cation channel subfamily c member 4a | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-20 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7DYU
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![BU of 7dyu by Molmil](/molmil-images/mine/7dyu) | Human JMJD5 in complex with MN and 5-((4-phenylbutyl)amino)pyridine-2,4-dicarboxylic acid. | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-(4-phenylbutylamino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, ... | 著者 | Nakashima, Y, Brewitz, L, Schofield, C.J. | 登録日 | 2021-01-23 | 公開日 | 2022-02-02 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
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7E8S
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![BU of 7e8s by Molmil](/molmil-images/mine/7e8s) | Intact TRAPPII (state I). | 分子名称: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | 著者 | Mi, C.C, Sui, S.F. | 登録日 | 2021-03-02 | 公開日 | 2022-02-09 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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3ITY
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![BU of 3ity by Molmil](/molmil-images/mine/3ity) | Metal-free form of Pseudomonas stutzeri L-rhamnose isomerase | 分子名称: | L-rhamnose isomerase | 著者 | Yoshida, H, Yamaji, M, Ishii, T, Izumori, K, Kamitori, S. | 登録日 | 2009-08-28 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Catalytic reaction mechanism of Pseudomonas stutzeri l-rhamnose isomerase deduced from X-ray structures Febs J., 277, 2010
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7K6V
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7PL7
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![BU of 7pl7 by Molmil](/molmil-images/mine/7pl7) | |
2M6W
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![BU of 2m6w by Molmil](/molmil-images/mine/2m6w) | |