4LPG
| Crystal structure of human FPPS in complex with CL01131 | 分子名称: | ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, PHOSPHATE ION | 著者 | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | 登録日 | 2013-07-16 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. J.Med.Chem., 57, 2014
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6ESQ
| Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA | 分子名称: | CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ... | 著者 | Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T. | 登録日 | 2017-10-24 | 公開日 | 2018-03-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4LS8
| Crystal structure of Bacillus subtilis beta-ketoacyl-ACP synthase II (FabF) in a covalent complex with cerulenin | 分子名称: | (3R,7E,10E)-3-hydroxy-4-oxododeca-7,10-dienamide, 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... | 著者 | Trajtenberg, F, Larrieux, N, Buschiazzo, A. | 登録日 | 2013-07-22 | 公開日 | 2014-04-02 | 最終更新日 | 2014-06-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into bacterial resistance to cerulenin. Febs J., 281, 2014
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6IAD
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3RYO
| Crystal Structure of Enhanced Intracellular Survival (Eis) Protein from Mycobacterium tuberculosis with Acetyl CoA | 分子名称: | ACETYL COENZYME *A, Enhanced intracellular survival protein | 著者 | Kim, K.H, An, D.R, Yoon, J.Y, Kim, H.S, Yoon, H.J, Song, J, Im, H.N, Kim, J, Kim, D.J, Lee, S.J, Kim, H.J, Lee, J.Y, Suh, S.W. | 登録日 | 2011-05-11 | 公開日 | 2012-05-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7 Proc.Natl.Acad.Sci.USA, 2012
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5XK6
| Structure of a prenyltransferase soaked with IPP | 分子名称: | MAGNESIUM ION, PYROPHOSPHATE 2-, SULFATE ION, ... | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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3S1I
| Crystal structure of oxygen-bound hell's gate globin I | 分子名称: | Hemoglobin-like flavoprotein, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Teh, A.H, Saito, J.A, Baharuddin, A, Tuckerman, J.R, Newhouse, J.S, Kanbe, M, Newhouse, E.I, Rahim, R.A, Favier, F, Didierjean, C, Sousa, E.H.S, Stott, M.B, Dunfield, P.F, Gonzalez, G, Gilles-Gonzalez, M.A, Najimudin, N, Alam, M. | 登録日 | 2011-05-15 | 公開日 | 2011-09-21 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin Febs Lett., 585, 2011
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5X5A
| Human thymidylate synthase bound with phosphate ion | 分子名称: | PHOSPHATE ION, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-15 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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2XWY
| Structure of MK-3281, a Potent Non-Nucleoside Finger-Loop Inhibitor, in complex with the Hepatitis C Virus NS5B Polymerase | 分子名称: | (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Di Marco, S, Baiocco, P. | 登録日 | 2010-11-06 | 公開日 | 2010-12-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Discovery of (7R)-14-Cyclohexyl-7-{[2-(Dimethylamino)Ethyl] (Methyl)Amino}-7,8-Dihydro-6H-Indolo[1,2-E][1,5] Benzoxazocine -11-Carboxylic Acid (Mk-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus Ns5B Polymerase J.Med.Chem., 54, 2011
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5X66
| Human thymidylate synthase in complex with dUMP and methotrexate | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, Thymidylate synthase | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | 登録日 | 2017-02-21 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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2A9W
| E. coli TS complexed with dUMP and inhibitor GA9 | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-BROMOPHENOL, 3,3-BIS(3-BROMO-4-HYDROXYPHENYL)-7-CHLORO-1H,3H-BENZO[DE]ISOCHROMEN-1-ONE, ... | 著者 | Finer-Moore, J.S, Anderson, A.C, O'Neil, R.H, Costi, M.P, Ferrari, S, Krucinski, J, Stroud, R.M. | 登録日 | 2005-07-12 | 公開日 | 2005-10-11 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr.,Sect.D, 61, 2005
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4LUA
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5XCP
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3RYE
| Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate | 分子名称: | 3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | 著者 | Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M. | 登録日 | 2011-05-11 | 公開日 | 2011-06-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate To be Published
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3RYW
| Crystal structure of P. vivax geranylgeranyl diphosphate synthase complexed with BPH-811 | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... | 著者 | No, J.H, Liu, Y.-L, Zhang, Y, Oldfield, E. | 登録日 | 2011-05-11 | 公開日 | 2012-05-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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6EWJ
| Putative sugar aminotransferase Spr1654 from Streptococcus pneumoniae, apo-form | 分子名称: | Putative capsular polysaccharide biosynthesis protein | 著者 | Achour, A, Sun, R, Sandalova, T, Han, X. | 登録日 | 2017-11-04 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis inStreptococcus pneumoniae. Open Biol, 8, 2018
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5XK3
| Crystal structure of apo form Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 | 分子名称: | SULFATE ION, Undecaprenyl diphosphate synthase | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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7AGH
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7AG6
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6F48
| Structure of quinolinate synthase with reaction intermediates X and Y | 分子名称: | 2-imino,3-carboxy,5-hydroxy,6-oxo hexanoic acid, 5-hydroxy,-4,5-dihydroquinolinate, CHLORIDE ION, ... | 著者 | Volbeda, A, Fontecilla-Camps, J.C. | 登録日 | 2017-11-29 | 公開日 | 2018-04-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA. ACS Chem. Biol., 13, 2018
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7AGK
| Crystal structure of E. coli SF kinase (YihV) in complex with product sulfofructose phosphate (SFP) | 分子名称: | Sulfofructose kinase, [(2~{S},3~{S},4~{S},5~{R})-3,4,5-tris(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]methanesulfonic acid | 著者 | Sharma, M, Davies, G.J. | 登録日 | 2020-09-22 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis. Acs Cent.Sci., 7, 2021
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5XNF
| Crystal structure of the branched-chain polyamine synthase (BpsA) from Thermococcus kodakarensis | 分子名称: | FE (III) ION, GLYCEROL, N(4)-bis(aminopropyl)spermidine synthase, ... | 著者 | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | 登録日 | 2017-05-22 | 公開日 | 2018-08-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine. FEBS J., 284, 2017
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7AM2
| Intermediate assembly of the Large subunit from Leishmania major mitochondrial ribosome | 分子名称: | 50S ribosomal protein L13-like protein, ADENOSINE-5'-TRIPHOSPHATE, Acyl carrier protein, ... | 著者 | Soufari, H, Waltz, F, Parrot, C, Bochler, A, Hashem, Y. | 登録日 | 2020-10-07 | 公開日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis. Proc.Natl.Acad.Sci.USA, 117, 2020
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2AAY
| EPSP synthase liganded with shikimate and glyphosate | 分子名称: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 3-phosphoshikimate 1-carboxyvinyltransferase, FORMIC ACID, ... | 著者 | Priestman, M.A, Healy, M.L, Funke, T, Becker, A. | 登録日 | 2005-07-14 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate. Febs Lett., 579, 2005
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3S4J
| Human FDPS Synthase in Complex with a Rigid Analog of Risedronate | 分子名称: | 6,7-dihydro-5H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | 著者 | Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M. | 登録日 | 2011-05-19 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Human FDPS Synthase in Complex with a Rigid Analog of Risedronate To be Published
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