4LPG

Crystal structure of human FPPS in complex with CL01131

Summary for 4LPG

Entry DOI	10.2210/pdb4lpg/pdb
Related	4JPH
Descriptor	Farnesyl pyrophosphate synthase, PHOSPHATE ION, ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid), ... (4 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43655.25
Authors	Park, J.,Leung, C.Y.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2013-07-16, release date: 2014-06-25, Last modification date: 2023-09-20)
Primary citation	De Schutter, J.W.,Park, J.,Leung, C.Y.,Gormley, P.,Lin, Y.S.,Hu, Z.,Berghuis, A.M.,Poirier, J.,Tsantrizos, Y.S. Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. J.Med.Chem., 57:5764-5776, 2014 Cited by PubMed: 24911527 DOI: 10.1021/jm500629e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation