2A9W

E. coli TS complexed with dUMP and inhibitor GA9

Summary for 2A9W

Entry DOI	10.2210/pdb2a9w/pdb
Descriptor	Thymidylate synthase, PHOSPHATE ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (8 entities in total)
Functional Keywords	protein-inhibitor complex, transferase
Biological source	Escherichia coli
Cellular location	Cytoplasm: P0A884
Total number of polymer chains	4
Total formula weight	128260.00
Authors	Finer-Moore, J.S.,Anderson, A.C.,O'Neil, R.H.,Costi, M.P.,Ferrari, S.,Krucinski, J.,Stroud, R.M. (deposition date: 2005-07-12, release date: 2005-10-11, Last modification date: 2023-08-23)
Primary citation	Finer-Moore, J.S.,Anderson, A.C.,O'Neil, R.H.,Costi, M.P.,Ferrari, S.,Krucinski, J.,Stroud, R.M. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr.,Sect.D, 61:1320-1334, 2005 Cited by PubMed: 16204883 DOI: 10.1107/S0907444905022638 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation